Description | Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MPLTGVFFISSNPNASTALATITERISSKFADESTPVARWALEHKLMRDTPSCIPSSGTKRPTAPKYMQFLSLAHYPTHGFVYASQPPDGTGHGSAAATATPTPSSSQSSQPAHVTTPMTMTTVPLPSTNALYQHFVHACQPFWCPRHTTVVPNGMVYEIGDFRVRVGDVRQTQPTARVRGTVVEIEWRGPSLVSTLSGLYQSRRQKKASATHPYTWGQGENDDDDSGIDMAFPDAVEESDIDAEYAATASLIREFWAKLELEGAREAILVPDVGKEVKEQLRKLKQENKQNANQKRNEDANGQQMDEDPDPNAGVDVARQFMEILRFNR |
Length | 330 |
Position | Head |
Organism | Aspergillus versicolor CBS 583.65 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.574 |
Instability index | 46.05 |
Isoelectric point | 5.87 |
Molecular weight | 36420.27 |
Publications | PubMed=28196534 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11162 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.94| 15| 85| 218| 232| 2 --------------------------------------------------------------------------- 218- 232 (28.87/20.07) GQ..GENDDDDSGIDMA 303- 319 (24.07/15.52) GQqmDEDPDPNAGVDVA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 122.88| 43| 85| 15| 94| 3 --------------------------------------------------------------------------- 13- 87 (52.12/80.35) P.......nASTAlatiterisskfadesTPvarwalehklmrdTPSCIPSSGTKRPTAPKYMQFLSL....AHYpTHgFVYASQP 88- 142 (70.76/47.53) PdgtghgsaAATA................TP.............TPSSSQSSQPAHVTTPMTMTTVPLpstnALY.QH.FVHACQP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EDPDP 2) QLRKLKQ 3) VARQFMEILRFNR | 308 281 318 | 312 287 330 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab