<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11160

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEDGINVDDLFGESTSLQLGLPPNTSPAPAKGLAQRLDEMRLVGCCQKIAWSRLGCVAYISQDSSRVNVRHLQCQKSDGKWTLSDETPLNQVAEAHDGHALVHLCWNESGSELAIADTSGRVSIYSIPIALNSVNGARQAAFDAADDGAQIVGMMWLNQNRSVHSFYQAAKVQGRWAYSPFRRRPIAPFHPVNKAALLCITRSGTMKLLYQNPDNKWAEITTELKNTSYSDRLLTHAALVATQAGILIATHSACQKISVYRVSIQWNPPQWDPAQQKQGSQPHPVPSFRSIHSKVEMPYDIPNNRGTAGENPDEQFTLTSSLYCLTSLQIILPASDNSAGSTPSPWIVAVFSIPPHAILHQQPQVPASAIIRWQLETGIPTLHPKFDEVASKKSNVQTKPKTILRRLDDITSDRHVISVDQTEYGNVLAVSYDDSSISFYDPKTMAAFDIVDDASTVTSLAQAGFNYPLDSSAIHTCFSPSACAAVGLDSDGQIHLRIMEHSYGAENGHYDENKFSAAIASLTLAFCRGCGGEVNTDDILLLLIRQLPQDSQTGFLNEVYRALSINCNFTTEHDKLMNHPYISRALSIQAALGFKNKYKTRNIVSNVPWAIIQLRQAAIIYPFFFQYNKGSQPPEPHDPDVLRMVLGNTKWVLDFFLYTLNELFDLADEFESVPADQEAFNQKLKSTASLPLIVVLSSMSRAFLRFICRGLRGIHSGYANAPLTGDARVYYTEICHALETSPVRTDVYEKLLAGVDSAVRHAYTGAGFGDNERPGPEKELLVSSRIPPVLVTAVSTILRQTIPSIKAEFDRMAIFMGDYSWLGFGSDARTEAYRRSREIDIIKKTPIFRAVAGAGSGRLGTMEVGDLGARSGTQGHLSRRCVRCCEASEAVYPPRSVPAFRMIYKLGHLRSCICGGMWDLESGLMT
Length930
PositionTail
OrganismAspergillus versicolor CBS 583.65
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.08
Grand average of hydropathy-0.184
Instability index42.66
Isoelectric point6.52
Molecular weight102555.33
Publications
PubMed=28196534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11160
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     140.63|      38|      92|      77|     114|       1
---------------------------------------------------------------------------
   77-   95 (23.41/10.64)	............................QCQKSDG.....KWTLSDETPLNQ
   96-  114 (22.12/ 9.63)	VAEAHDGHALVH..LCWNESG...............................
  190-  228 (50.35/31.77)	IAPFHPVNKAAL..LCITRSG...tmklLYQNPDN.....KWA...EITTEL
  229-  280 (44.74/27.37)	KNTSYSDRLLTHaaLVATQAGiliathsACQKISVyrvsiQWNPPQWDPAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.63|      18|     543|     165|     182|       2
---------------------------------------------------------------------------
  165-  182 (35.29/21.10)	RSVHSFYQAAKVQG..RWAY
  716-  735 (30.34/17.21)	RGIHSGYANAPLTGdaRVYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.62|      29|     543|     356|     385|       3
---------------------------------------------------------------------------
  356-  385 (48.91/38.54)	SIPPHAILHQQPQVpASAII..RWQLETGIPT
  900-  930 (50.71/34.21)	SVPAFRMIYKLGHL.RSCICggMWDLESGLMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      16|      17|     464|     479|       4
---------------------------------------------------------------------------
  464-  479 (28.30/15.67)	LA.QAGFNYPLDSSA.IH
  482-  499 (18.14/ 7.61)	FSpSACAAVGLDSDGqIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.68|      23|      38|     549|     572|       6
---------------------------------------------------------------------------
  549-  572 (36.95/35.65)	RQLPQDSQTGFlNEVYRALSINCN
  588-  610 (37.73/30.37)	RALSIQAALGF.KNKYKTRNIVSN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11160 with Med16 domain of Kingdom Fungi
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