<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11154
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDADSDWRSAPFRQKLVSQIDEAMRKAGVAHTKSSKDMESHVFLKAKTREEYLSLVARLIIHFRDILNKKSQAAATDPMNALQNLTGTAVVGGQGMGMGVRPQGAQMGAMSGMAQMAQQMNLPGQPQPGASGMAPHGITGVAAGNQATQLQLQQIAQHQQQQFQQQQQQAALQHQQQQFQVAQQQQFQVAAVAAAQQQQQQQQQQQQQQQQVQQQQQQLQAAAQQQHILKLQLQQQQNQQQQLQQQQQQQLQRIAHLQQMQQMQQQQQQQQQQQQQQQQQPPPQQVMQLQQMQQQQVAQSQQQQLLSTQPQAPSLVAQGQIPSQVMPVTLTPQQQQQLKILQQVRAQQQQQAQHQAQQQAQQQAHQQAQQQAQQQAQQQAAQQQAQQAAQQAQQQAQQAAQQQAAQAHLAAGQMISTSMARGGMPVRPRFPPSTVPANPTSTVPLGEQQIPQVTQNSIPVMSSPSPVQQVQTPQPMPPPPQPSPQPSQPMSQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASARTPQNFSVPSPGPLNTPGNPNSVMSPASNNQSEEQQYLDKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPNKRCPLKTLQKCEIALEKLKNDMAVPTPPPPTVPSTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPIASQLVVPRKRKFEEDERQSIPNVLQGEVAKLHSKFLVNLDPSHCSNNGTVYLICKLDDKNLPSVPPLQLSVPADYPDQSPLWMDNPRDYEANPFLQSVYRYMTSKLLQLPDKHSLTALLNTWAQSIRQACLSAA |
Length | 816 |
Position | Tail |
Organism | Xenopus laevis (African clawed frog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia>
Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.834 |
Instability index | 83.79 |
Isoelectric point | 9.59 |
Molecular weight | 90773.36 |
Publications | PubMed=27762356
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11154
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 253.77| 38| 38| 149| 186| 1
---------------------------------------------------------------------------
158- 197 (64.38/ 9.83) HQQ.QQFQQQQQQAALQHQQQQFQVAQQQ.....QFQVAAVAaaqQ
198- 237 (63.45/ 9.56) QQQ.QQQQQQQQQQQVQQQQQQLQAAAQQQ.hilKLQLQQ.Q...Q
257- 299 (66.38/10.40) LQQmQQMQQQQQQQQQQQQQQQQQPPPQQVmqlqQMQQQQVA...Q
354- 386 (59.57/ 8.44) HQA.Q..QQAQQQA...HQQAQQQAQQQAQ....QQAAQQQA...Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.84| 28| 28| 462| 489| 2
---------------------------------------------------------------------------
458- 487 (52.97/12.59) IPvmSSP.SPVQQVQTPQPMPPPPQPSPQPS
488- 517 (36.88/ 6.35) QP.mSQPnSNVSSGPAPSPSSFMPSPSPQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 114.64| 26| 96| 301| 328| 3
---------------------------------------------------------------------------
301- 326 (49.81/15.75) QQQQLLSTQPQAP.SLVAQG..QIPSQVM
395- 419 (39.20/ 9.22) QAQQ.AAQQQAAQ.AHLAAG..QMISTSM
427- 453 (25.63/ 6.73) RPRFPPSTVPANPtSTVPLGeqQIP.QV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.38| 24| 28| 591| 617| 4
---------------------------------------------------------------------------
591- 615 (37.87/19.66) LSKMKSLLDILTDPNKRCPlKTLQK
620- 643 (41.51/21.45) LEKLKNDMAVPTPPPPTVP.STKQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.48| 30| 42| 87| 118| 6
---------------------------------------------------------------------------
87- 118 (47.09/30.45) GTAVVGGQGM...GM.GVrPQGAQMGAMSgMAQMAQ
124- 157 (43.40/20.01) GQPQPGASGMaphGItGV.AAGNQATQLQ.LQQIAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 139.12| 47| 212| 527| 583| 8
---------------------------------------------------------------------------
527- 583 (70.27/46.27) QNF.SVPsPGPLNTPGN.PN.SVMSPASNNQSEEQQYldkLKQLSKYieplrrMINKI....DK
741- 794 (68.85/28.42) KNLpSVP.PLQLSVPADyPDqSPLWMDNPRDYEANPF...LQSVYRY......MTSKLlqlpDK
---------------------------------------------------------------------------
|