<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11153

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDADSDWRSAPFRQKLVSQIDEAMRKAGVAHTKSSKDMESHVFLKAKTREEYLSLVARLIIHFRDILNKKSQAAATDPMNALQNLTGTAVVGGQGMGMGVRPQGAQMGAMSGMAQMAQQMNLPGQPQPGASGMAPHGITGVAAGNQATQLQLQQIAQHQQQQFQQQQQQAALQHQQQQFQVAQQQQFQVAAVAAAQQQQQQQQQQQQQQQQVQQQQQQLQAAAQQQHILKLQLQQQQNQQQQLQQQQQQQLQRIAHLQQMQQMQQQQQQQQQQQQQQQQQPPPQQVMQLQQMQQQQVAQSQQQQLLSTQPQAPSLVAQGQIPSQVMPVTLTPQQQQQLKILQQVRAQQQQQAQHQAQQQAQQQAHQQAQQQAQQQAQQQAAQQQAQQAAQQAQQQAQQAAQQQAAQAHLAAGQVTQNSIPVMSSPSPVQQVQTPQPMPPPPQPSPQPSQPMSQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASARTPQNFSVPSPGPLNTPGNPNSVMSPASNNQSEEQQYLDKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPNKRCPLKTLQKCEIALEKLKNDMAVPTPPPPTVPSTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPIASQLVVPRKRKFEEDERQSIPNVLQGEVAKLHSKFLVNLDPSHCSNNGTVYLICKLDDKNLPSVPPLQLSVPADYPDQSPLWMDNPRDYEANPFLQSVYRYMTSKLLQLPDKHSLTALLNTWAQSIRQACLSAA
Length777
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.03
Grand average of hydropathy-0.858
Instability index84.27
Isoelectric point9.50
Molecular weight86656.62
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11153
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     243.36|      35|      38|     149|     186|       1
---------------------------------------------------------------------------
  158-  194 (60.06/13.73)	HQQQQFQQQQQQaalQHQQQQFQVAQQQ.....QFQVAAVAA
  195-  224 (62.81/11.18)	AQQQQ.QQQQQ....QQQQQQ.QV..QQQ....QQQLQAAAQ
  263-  299 (64.37/11.70)	MQQQQQQQQQQQ.....QQQQQQPPPQQVmqlqQMQQQQVAQ
  347-  375 (56.12/ 8.97)	QQQQQAQHQAQQ...QAQQQAHQQAQQ........QAQQ..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.60|      37|     154|     225|     262|       2
---------------------------------------------------------------------------
  225-  261 (67.55/14.19)	QQHILKLQLQQQQNQQQQLQQQQQQQLQRIAH.LQQMQ
  415-  452 (51.06/ 9.72)	TQNSIPVMSSPSPVQQVQTPQPMPPPPQPSPQpSQPMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.97|      25|      29|     462|     490|       4
---------------------------------------------------------------------------
  466-  490 (48.56/21.71)	PSSFMPSPSPQPSQSPASARTPQNF
  588-  605 (28.35/ 6.39)	....MAVPTPPP...PTVPSTKQQY
  708-  732 (46.06/13.29)	PPLQLSVPADYPDQSPLWMDNPRDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.43|      20|      22|      94|     113|       5
---------------------------------------------------------------------------
   94-  113 (38.17/18.75)	QGMGMGVRPQ.GAQMGAMSGM
  118-  138 (31.26/13.92)	QQMNLPGQPQpGASGMAPHGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.44|      11|      49|     453|     463|       6
---------------------------------------------------------------------------
  453-  463 (20.35/12.22)	QPNSNVSSGPA
  492-  502 (19.53/11.35)	VPSPGPLNTPG
  503-  511 (17.55/ 9.24)	NPNSVMS..PA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.50|      14|      22|     526|     546|       7
---------------------------------------------------------------------------
  526-  540 (19.40/12.05)	KQLSKyIEPLRRMIN
  550-  563 (22.10/19.40)	KDLSK.MKSLLDILT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.59|      20|      91|     301|     321|       8
---------------------------------------------------------------------------
  301-  321 (31.76/17.84)	QQQQlLSTQPQAPSLVAQGQI
  395-  414 (33.83/14.69)	QAQQ.AAQQQAAQAHLAAGQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11153 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GQGMGMGVRPQGAQMGAMSGMAQMAQQMNLPGQPQPGASGMAPHGITGVA
2) IEPLRRMINKIDKNEERKKDLSKMKSLLDI
3) QAQHQAQQQAQQQAHQQAQQQAQQQAQQQAAQQQAQQAAQQAQQQAQQAAQQQAAQAHLAAGQVTQNSIPVMSSPSPVQQVQTPQPMPPPPQPSPQPSQPMSQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASARTPQNFSVPSPGPLNTPGNPNSVMSPASNNQSEEQQYLDKLKQLS
93
532
351
142
561
529










Molecular Recognition Features






MoRF SequenceStartStop




NANANA