<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11152

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWAANGASLEDCHSNLFSLAELTGIKWRRYRYQGPGECGPIISAPAQDDPILLSFIRCLQANLLCVWRREVKPDRKELWIFWWGDEPNLGEVIHHELQMDEEGLWENGLSYECRTLLFKAIHNLLERCLLDKNFVRIGKWFVKPCEKEEKSLSKSENLSCSFTFFLHGESNVCTSVEIAQHQPVYLINQQHLHLAQTSHAPCQVILSPYGLSGTLTGHGYKTSDPTTRKLLEEWRPFYPTVLRVRQDQQEELQYNDDFPAAVEVIVGGVRLVYPSAFVLIAQSDLPLSSSVGGAGHNNTGGQQSTAVTKDPSPCRMPLTPPTSPEQIAPVDGKENFSSINSHSTEDGVSNPKQTSKCGERSCHRLSSHMAQRVWKECIVNRCQPKLTISNQQEGENPVSKAPWDFVDPSHRATCSCSRHKYSKQRGVPSGCRPSSVTQPSMGGIPTSCSSSLPPPASSKHKPTDRPEKAEKLQKKTTTPFHHRALPTQNEQCLTQETAVQQRQGAEAATSAQPNRQYQSLSSAGELDQLLPSQPSDSPHSPASPMPPTLSPQPPQQDVAIPDPEVQPCNSILYPHGLEMQPLDDRTMMLAGLGLPLMAELSETSIYCSSLSQIQQSENWQEYKLPSTGNEDFRPPNILVEWHENIQETRAESTALERLLAQPNKRFKVLDGKRPILSDNCTYLDQPPIYREQFGDIRDPYAFEDGEIKYSFTANKKCKMGAERDLSLKLKADEGFEKNASPTEQPASVTDPGKNVMSIFSPASKPDPRQDRGIAASLTQVKDLAPSLNDLDNLFDNSEDEDLAGSPGTRAMKVRSVGSEDRALGKDARTAVAYSATDLQRMFPTPPSLEQHPAFSPIMIYKDGVGSETTATLAMMESPMVNLATMHHLEFKMEVEDALCSPKPEEIRDFSYVHRVSACQSFVGTSMFAPLKYLPSQCLLSLKVPDACVYRPSWAAPPKMQHLPLPPATSFNRDGYMNVPSVGSLTDPDYLQLNTPQTNTPLAPCSTAPASNGGTGGVLPSPATPRFSVPTPRTPRTPRTPRGGGGASGQGSAKYDSTDLCSPASTPSTTRPLSSVEPASSHPAPEAHSLYVTLLLSDSVLNIFKDRNFDSCCICACNLNVKGADVGIYIPDSSNEDQYRCTCGFSAIVNRRLGYNSGLFIEDEMDIFGRSSDLGQAVERRLNIRVTERLGQEQPPSGLLLLLQRQCTRPFNNCSSTWELSYCQGVSLLDRPSWNYDRVRAESSDAWPECLNALEQGRQYVDNPTGGRVDEALVKSATFHLWPHSNVLDVSMLPSQDVVHMLLSLQPCLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPNLLVGYDKDFLTIAPFSLPFWERLSLEPYGGQRDVGYLVLCPENSALLDGAKAFFRDMSAVYEMCRLGEHRPICKVFSDGIMKISQPAGETEETSCEDMDNQARLQLFAQTCRQQLAPYLSTLQLDNSLLLPPKNQPSTVQPNVSPAVPSCPPGVLFNTTPNGTSTTPLPPPPLSSSTSHPAGNSTVPTVFNNCPSQNASSSVERPLGSQSTGDPELSQQFIQQETPESATEREKIGIPTEAEPAVALSSCPTVVIYMVDPFTYTVDEDCHPGNYWMLGLIRCFTDMLESLPEPLRTSCILQVVPCQSLLQTVNDEEVSYIQHLKSLAFSVYCQCWRPIATQIPIKPLTGFGPAAALNAILRTQEQPISGQVYSPPFLLSPTKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLQGELLETCVVNIHVPNRFRRSKVSARKIGLQKLWEWCVEIIQTTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISRQLKETCKMCGISATDSPSILSACLVAMEPQGSFIVMPDAVTMGSVFGRSTALNLQTSQLSTPQDASCTHILVFPTSATIQVSPANYHNEEDMLDLPFLDDMDNDIGILITGNLHSPPNSSPGSPIGAGPHFQHSRSQVERLLSRETPEELKQQPLALGYYVSTAKAENLPEWFWSSCPQAQNQCPLFLKASLHHHISISHNEDLVPARTSQRVTHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPIHFTVLIQMYNMVMDFL
Length2135
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.404
Instability index56.54
Isoelectric point5.52
Molecular weight235844.96
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11152
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.70|      31|      32|    1512|    1543|       1
---------------------------------------------------------------------------
 1523- 1556 (52.36/21.63)	PNGTSTTPLPPPPLSSSTSHP...............................agnSTVPTV.FNNC
 1557- 1622 (32.34/13.56)	PSQNASSSVERPLGSQSTGDPelsqqfiqqetpesaterekigipteaepavalsSCPTVViYMVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.26|      32|      32|     987|    1018|       2
---------------------------------------------------------------------------
  306-  328 (25.57/ 7.18)	G........QQS..TAVT.KDP.SPCRmplTPPTS...
  987- 1018 (59.69/28.52)	GSLTDPDYLQLN..TPQT.NTPLAPCS...TAPASNGG
 1021- 1055 (48.00/21.21)	GVLPSPATPRFSvpTPRTpRTPRTPRG...GGGASGQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.06|      25|      26|      60|      84|       3
---------------------------------------------------------------------------
   60-   84 (47.68/34.63)	FIRCLQANLLCVWRREVKPDRKELW
   86-  110 (50.39/37.11)	FWWGDEPNLGEVIHHELQMDEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.18|      20|      26|     622|     641|       4
---------------------------------------------------------------------------
  622-  641 (40.30/22.05)	ENWQEYKLPSTGNED.FRPPN
  648-  668 (29.88/14.49)	ENIQETRAESTALERlLAQPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.51|      16|      26|     922|     946|       6
---------------------------------------------------------------------------
  922-  939 (26.92/30.22)	ACqsFVGTSMFAP..LKYLP
  951-  968 (29.60/ 9.76)	AC..VYRPSWAAPpkMQHLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.17|      25|      28|    1112|    1136|       7
---------------------------------------------------------------------------
 1112- 1136 (49.58/33.00)	NFDSC.CICACNLNVK...GADVGIYIPD
 1139- 1167 (38.59/23.87)	NEDQYrCTCGFSAIVNrrlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     301.69|      86|     200|     137|     225|       8
---------------------------------------------------------------------------
  137-  223 (147.50/100.59)	KNFVRIGKWFVKPCEKEEKSLSKSENLSCsFTFFLHGESNVCTSVEIAQHQPVYLINQQHLHLAQTSHAPCQVILSPYGLSGTLTGH
  339-  424 (154.18/107.07)	ENFSSINSHSTEDGVSNPKQTSKCGERSC.HRLSSHMAQRVWKECIVNRCQPKLTISNQQEGENPVSKAPWDFVDPSHRATCSCSRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.33|      20|      28|    1184|    1209|       9
---------------------------------------------------------------------------
 1184- 1204 (30.60/25.86)	RRL.NIRVTERLGQEQPPSgLL
 1213- 1233 (34.74/13.33)	RPFnNCSSTWELSYCQGVS.LL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.05|      28|      32|    2007|    2034|      11
---------------------------------------------------------------------------
 2007- 2034 (46.33/24.93)	LSRETPEELKQQPL....ALGYYVSTAKAENL
 2038- 2069 (48.72/26.62)	FWSSCPQAQNQCPLflkaSLHHHISISHNEDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.15|      26|      32|    1234|    1259|      12
---------------------------------------------------------------------------
  769-  796 (32.28/16.66)	.KPDPR.QDR..GIAASltqvKDLAP.SLNDLD
 1234- 1259 (49.39/29.93)	DRPSWN.YDR..VRAES....SDAWPECLNALE
 1266- 1293 (36.47/19.91)	DNPTGGrVDEalVKSAT....FHLWPHS.NVLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      11|      25|    1367|    1377|      13
---------------------------------------------------------------------------
 1367- 1377 (20.74/11.33)	GYDKD..FLTIAP
 1392- 1404 (17.24/ 8.16)	GGQRDvgYLVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.43|      12|      26|    1699|    1710|      14
---------------------------------------------------------------------------
 1699- 1710 (21.77/11.17)	RPIATQIPIKPL
 1728- 1739 (23.65/12.87)	QPISGQVYSPPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.84|      21|      25|     478|     498|      15
---------------------------------------------------------------------------
  478-  498 (37.94/19.90)	QKKTTTPFHHRALPTQNEQCL
  505-  525 (34.90/17.72)	QQRQGAEAATSAQPNRQYQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      13|      16|     431|     445|      16
---------------------------------------------------------------------------
  431-  444 (23.05/ 7.73)	GVPSGCrPSSVTQP
  448-  460 (25.86/ 6.47)	GIPTSC.SSSLPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.21|      13|      20|     802|     815|      17
---------------------------------------------------------------------------
  802-  815 (19.11/13.78)	SEDEDLaGSPGTRA
  823-  835 (22.10/11.31)	SEDRAL.GKDARTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     208.40|      70|     751|     674|     750|      19
---------------------------------------------------------------------------
  674-  750 (116.84/90.13)	LDGKRPIlsdnctYLDQPPIYRE.QFGDIRdPY..AFEDGEIKYSF....TANKKC.KMGAERDLSL..............KLKADEGF...EKNASPTEQP
 1410- 1504 (91.56/55.43)	LDGAKAF......FRDMSAVYEMcRLGEHR.PIckVFSDGIMKISQpageTEETSCeDMDNQARLQLfaqtcrqqlapylsTLQLDNSLllpPKNQPSTVQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11152 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKADEGFEKNASPTEQPASVTDPGKNVMSIFSPASKPDPRQDRGIAASLT
2) LLPPKNQPSTVQPNVSPAVPSCPPGVLFNTTPNGTSTTPLPPPPLSSSTSHPAGNSTVPTVFNNCPSQNASSSVERPLGSQSTGDPELSQQFIQQETPESATEREKIGIP
3) NDLDNLFDNSEDEDLAGSPGTRAMKVRSVGSEDR
4) PPNSSPGSPIGAGPHFQHSRSQVERLLSRETP
5) RGVPSGCRPSSVTQPSMGGIPTSCSSSLPPPASSKHKPTDRPEKAEKLQKKTTTPFHHRALPTQNEQCLTQETAVQQRQGAEAATSAQPNRQYQSLSSAGELDQLLPSQPSDSPHSPASPMPPTLSPQPPQQDVAIPDPEVQPCNSILYPHGL
6) SSVGGAGHNNTGGQQSTAVTKDPSPCRMPLTPPTSPEQIAPVDGKENFSSINSHSTEDGVSNPKQTSKCGERSC
7) VGSLTDPDYLQLNTPQTNTPLAPCSTAPASNGGTGGVLPSPATPRFSVPTPRTPRTPRTPRGGGGASGQGSAKYDSTDLCSPASTPSTTRPLSSVEPASSH
734
1492
793
1981
430
294
986
783
1601
826
2012
582
367
1086










Molecular Recognition Features






MoRF SequenceStartStop




NANANA