<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11150

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVAYICEWDRRPRTSHCPSIPLVCAWSCRNLIAFTTDQRNEEEKDITNLIHILDTEHPWDVYSINSGHQEVITCLEWDQSGSRLLSADADGRIKCWGMTDHLANSWQNLVGSEVDGDPIVALSWLHNGVKLALHVEKSGVSSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPNGQVLTATESLCRLRCRVALADIAFTGGGNIVVATCDGSSTSPVQFYKVCVSVVSEKCKIDTEILPSLFMRCTTDPARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPLNNIFQQLSPAVSDKQPMILKWRILSATNELERVSAVALPKLPISLTNTDIKVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEPSLKRQRSPTPCIHFKALQMSWTSLALVGLDTQGKLSILRVSPSMGHSLDMSTSLRHLLFLLEYCMVTGYDWWDILLHVQPGMVHNLVEKLNEEYTRQNAALQQVLSTRILAMKASLCKLSQTTVTRVCDYHAKLFLISISCTLKSLLRPHVLNTPDKSPGDRLTEICNKFTDTDIDKVMINLKTEEFVLDMPTLQSLQQLIQWLGDFVLYLLVSLPNQGSSVRPGHSFLRDGASLGTLREMMVMIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTRLWLCCRDESHPCDPDESLIDECCLLPSQLLIPNMDWLPLGNGIISRLQSKLPLRLQFGKPPGAPSYASVHYEAHTRSPTQPKIDHLRRLHLGTFPTEACKSCTRCGCVTMLKSPNKATAVKQWEQRWIKTCLCGGLWRKMPHAYS
Length828
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.049
Instability index51.00
Isoelectric point8.27
Molecular weight92533.47
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11150
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.39|      66|      96|     249|     316|       1
---------------------------------------------------------------------------
  249-  316 (115.12/74.87)	LPSLFMRCT.TD..PARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPlnNIFQQLSP
  345-  413 (105.27/62.85)	LPKLPISLTnTDikVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEP..SLKRQRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.27|      50|     494|     105|     204|       3
---------------------------------------------------------------------------
  123-  184 (68.33/99.54)	LSWLHNGV...KLALHVEKSGVSSfGEKFSRVkfSPSLtlfgGKPMEGWIAVTVSGLvtvslLKP
  606-  658 (86.94/32.41)	IQWLGDFVlylLVSLPNQGSSVRP.GHSFLRD..GASL....GTLREMMVMIRIWGL.....LKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.87|      10|     494|     195|     204|       9
---------------------------------------------------------------------------
  195-  204 (19.51/ 9.74)	LCRLRCRVAL
  677-  686 (18.36/ 8.75)	LFRLLTRLWL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11150 with Med16 domain of Kingdom Metazoa
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