<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11149

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVAYICEWDRRPRTSHCPSIPLVCAWSCRNLIAFTTDQRNEEEKDITNLIHILDTEHPWDVYSINSGHQEVITCLEWDQSGSRLLSADADGRIKCWGMTDHLANSWQNLVGSEVDGDPIVALSWLHNGVKLALHVEKSGVSSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPNGQVLTATESLCRLRCRVALADIAFTGGGNIVVATCDGSSTSPVQFYKVCVSVVSEKCKIDTEILPSLFMRCTTDPARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPLNNIFQQLSPAVSDKQPMILKWRILSATNELERVSAVALPKLPISLTNTDIKVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEPSLKRQRSPTPCIHFKALQMSWTSLALVGLDTQGKLSILRVSPSMGHSLDMSTSLRHLLFLLEYCMVTGYDWWDILLHVQPGMVHNLVEKLNEEYTRQNAALQQVLSTRILAMKASLCKLSQTTVTRVCDYHAKLFLISISCTLKSLLRPHVLNTPDKSPGDRLTEICNKFTDTDIDKVMINLKTEEFVLDMPTLQSLQQLIQWLGDFVLYLLVSLPNQGSSVRPGHSFLRDGASLGTLREMMVMIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTRLWLCCPPHNQRLIT
Length697
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy0.020
Instability index45.59
Isoelectric point7.74
Molecular weight77801.48
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11149
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.39|      66|      96|     249|     316|       1
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  249-  316 (115.12/71.86)	LPSLFMRCT.TD..PARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPlnNIFQQLSP
  345-  413 (105.27/60.33)	LPKLPISLTnTDikVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEP..SLKRQRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     242.58|      56|     102|     414|     469|       4
---------------------------------------------------------------------------
  414-  469 (98.77/61.19)	TPCIHFKA..LQ..MSWTS....LALVGLDTQGK.....LSILRVS........PSMGHSLDMSTSLRHLLFLLEYC
  512-  572 (70.14/41.36)	TRILAMKAslCK..LSQTT....VTRV.CDYHAK.....LFLISISctlksllrPHVLNTPDKSPGDR....LTEIC
  596-  660 (73.68/43.81)	MPTL..QS..LQqlIQWLGdfvlYLLVSLPNQGSsvrpgHSFLRDG........ASLGTLREMMVMIRIWGLLKPSC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11149 with Med16 domain of Kingdom Metazoa
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