<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11148

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHTKSSKEMESHVFLKAKTREEYLSLVARLIIHFRDIFNKKNQTAASDPMNALQNLTGNAVVGGQGMGMGVRPQGAQMGAMGGMTQIAQQMNLPGQSQPGASGMAPHGITGVAAGNQATQLQLQQMAQHQQQQFQQQQHQAALQHQQQHQQQQFQVAQQQQFQVAAVAAAQQQQQQQQQQQQQQQVQQQQQQQQQQQVQQQQQQQVQQQQQQQVQQQQQQQVQQQQVQQQQQMQAAAQQQHILKFQLQQQQNQQQQLQQQQQLQRMAHLQMQQMQQQQQQQQQQQPPPPQVMQLQQMQQVAQSQQQQLLSTQPQAPSLVAQGQIPSQVMPVTLTPQQQLKLLQQVRVQQHQAQQQAQQQAQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQQAQQQAQQQAQQAAQKHQAAQQHQAAQQHQAAQQHQAAKQHQAAQQQAQQAAQQAQQQAQQQAAQQQAAQAHLAAGQMISTPMPRGGMPVRPRFPPSTVPANPTSSVPLGEQQIPQVNQNSIPVMSSPSPVQAQTTQSMPPPPQPSPQPSQPISQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASVRTPQNFSVPSPGPLNTPGNPNSVMSPASNNQSEEQQYLDKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLDILTDPNKRCPLKTLQKCEIALEKLKNDMAVPTPPPPTVPSTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPITSQLVVPRKRKFEEDERQGIPNVLQGEVAKLHSKFLVNLDPSHCSNNGTVYLICKIDDKNLPSVPPLQLSVPAEYPDQSPLWMDNPRQYEANPFLQSVYRYMTSKLLQLPDKHSLTALLNTWAQSIRQACLSAA
Length892
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.03
Grand average of hydropathy-0.997
Instability index83.57
Isoelectric point9.79
Molecular weight99891.70
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11148
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     416.68|      41|      41|     359|     399|       1
---------------------------------------------------------------------------
  152-  196 (73.19/ 9.75)	QQQHQQ.QQFQVAQQQQfqvaAVAAAQQQQQQQQQQQQQQQVQQQQ
  197-  232 (78.80/11.30)	QQQQQQ.QVQQQ.QQQQ....VQQQQ..QQQVQQQ..QQQQVQQQQ
  266-  306 (72.44/ 9.54)	QQQLQR.MAHLQMQQMQ....QQQQQQQQQQPPPPQVMQLQQMQQV
  359-  391 (68.17/ 8.35)	QQQAQQ.QAQQQAQQQQ....AQQQQAQQQQAQQQQAQ........
  392-  423 (63.89/ 7.17)	.........QQQAQQQQ....AQQQQAQQQQAQQQQA.QQQAQQQA
  424-  460 (60.20/ 6.14)	QQAAQKhQAAQQHQAAQ.....QHQAAQQHQA....AKQHQAAQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     149.20|      29|      29|     553|     581|       2
---------------------------------------------------------------------------
  502-  523 (30.31/ 7.02)	PVRPRFPPST.VPA..NPTSSVPLG..............
  524-  554 (29.75/ 6.73)	.EQQIPQVNQ.N.S..IP...VMSSPSPVQaqttqsmPP
  555-  586 (53.46/19.09)	PPQPSPQPSQ.PIS..QPNSNVSSGPAPSP....ssfMP
  587-  615 (35.68/ 9.82)	SP..SPQPSQsPASvrTPQN..FSVPSPGP......lNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.54|      23|     121|     119|     142|       3
---------------------------------------------------------------------------
  119-  142 (41.52/11.80)	AAGNQAT..QLQLQQmAQHQQQQFQQ
  241-  265 (43.02/ 9.54)	AAAQQQHilKFQLQQ.QQNQQQQLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.79|      27|      28|     667|     693|       4
---------------------------------------------------------------------------
  637-  661 (38.53/22.18)	LDKLKQLSKYI.EPLRRM.INKIDK..NE
  667-  693 (46.30/28.19)	LSKMKSLLDILTDPNKRCPLKTLQK..CE
  696-  723 (40.96/24.06)	LEKLKNDMAVPTPPPPTVP.STKQQylCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.69|      30|     158|     307|     336|       5
---------------------------------------------------------------------------
  307-  336 (54.55/20.36)	AQSQQQQLLSTQPQAPSLVAQGQIPSQVMP
  468-  497 (53.14/19.55)	AQQQAQQQAAQQQAAQAHLAAGQMISTPMP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11148 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QAQQQQAQQQQAQQQAQQQAQQAAQKHQAAQQHQAAQQHQAAQQHQAAKQHQAAQQQAQQAAQQAQQQAQQQAAQQQAAQAHLAAGQMISTPMPRGGMPVRPRFPPSTVPANPTSSVPLGEQQIPQVNQNSIPVMSSPSPVQAQTTQSMPPPPQPSPQPSQPISQPNSNVSSGPAPSPSSFMPSPSPQPSQSPASVRTPQNFSVPSPGPLNTPGNPNSVMSPASNNQSEEQQYLDKLKQLS
2) VGGQGMGMGVRPQGAQMGAMGGMTQIAQQMNLPGQSQPGASGMAPHGITGVAAGN
404
68
644
122










Molecular Recognition Features






MoRF SequenceStartStop




NANANA