<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11147

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWAANGASLEDCHSNLFSLAELTGIKWRRYRYQGPGECGPIISAPAQDDPILLSFIRCLQANLLCVWRREVKPDRKELWIFWWGDEPNLGDVIHHELHMDEEGLWENGLSYECRTLLFKAIHNLLERCLLDKDFVRIGKWFVKPCEKEEKSLSKSENLSCSFTFFLHGESNVCTSVEIAQHQPVYLINQQHLHLAQTSHAPCQVILSPYGLSGTLTGHGYKTSDPTTRKLLEEWRPFYPTVLRVRQDQQEEMQYNDDFPAAVEVIVAGVRLVYPSAFVLIAQSDLPLSSSVGGAGHSNTSGQQSTAVTKDPSPCRMPLTPPTSPEQIAPGDGKENYSSINGHSTEDSVSNTKQSSKCGERSCHRLRSQMAQKVWKECIVDKCQPKLTVSSQQEGENSVSKAPWDFVDPSHRATCNCSRHKYSKQRGAPSGCRPSSVTQPSMGGIPTSCSASLPPPASSKHKPSDRPEKAEKLQKKTTTPFHHRALPTQNEECLSQETAVQQRQGTEAATSTPPNRHFQSLPSAGELDQMLPSQPTDSPHSPASPMPPTLSPQPPQQEVAIPDPEVQPCSSTLYPNGLEMQPLDDRTMMVAGLGLPLMAELSETSIYCASLSQSQQSENSWQEYKLPSTSNEDFQPPNIPVERHESIQETLAERTALERLLAQPNKRFKVLDGKRPILSDTWTYLDQPPIYLEQHGDTLDPYTFEDGEIKYSFTANKKCKMGDLSWKLKSDEGFEKNASPTEQQASVTDPGKNVMSIFSPASKPDPRQDRGIAASLTQVKDLAPSLNDLDNLFDNSEDEDLAGSPGTRAMKVPSLGSEDRALGKDARMTVAYSATDLQRMFPTPPSLEQHPAFSPIMIYKDGVGSETTATLAIMESPLVNLATMHQLDFKMEVEEGLCSPKPEKIRDFSYVHRVPSCQSFVGTSMFAPLKSLPSQCLLSLKIPDACVYRPSWAAPPKMQHLPLPPATSFNRDGYMNVPSVGSLTDPDYLQLNTPQTNTPLAPCSTAPASNGGTGGVLPSPATPRFSVPTPRTPRTPRTPRGGGGASGQGSAKYDSTDLCSPASTPSTTRPLSSVEPASSHPAPEAHSLYVTLLLSDSVLNIFKDRNFDSCCICACNLNIKGADVGIYIPDSSNEDQYRCTCGFSAIVNRRLGYNSGLFIEDEMDIFGRSSDLGQAVERRLNIRVTERLGQEQPPSGLLLLLQRQCTRPFNNCCSTWELSYCQGVTLSDRPSWNYDRVRAESSDAWPECLNALEQGRQYVDNPTGGRVDEALVKSATFHLWPHSNVLDVSMLPSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPVPNLLVGYDKDFLTIAPFSLPFWERLLLEPYGGQRDVGYLVLCPENCALLDGAKAFFRDLSAVYEMCRLGEHRPICKVLSDGIIKISRPAGETEETSCEDMDNQARLQLFAQTCRQHLAPYLSTLQLDNSLLLPPKKQPSTVQTNLSPAVPSCPPGALINTTPNGTSTAPLPPPQLSSTTSLPAGNSTVPTGFNNCSSQNSSSSVERPLGNQSTGDPEPSQQSIQQETPENATERERIGIPTEPDGAITSCPTVVIYMVDPFTYTVDEDCHPGNYWMLGLIRCFTDMLESLPEPIRNACILQVVPCQSLLQTVNDEDVSYIQHLKSLAFSVYCQCQRPIATQIPIKPLTGFGPAAALNAILRNQEQPSPGQMYSPPFLLCPTKDKQTELGETFGEAGQKYNVMFVGYCLSHDQRWLLASCTDLQGELLETCVVNIHVPNRFRRSKVSARKIGLQKLWEWCVEIIQTTSVPWRVVIGRLGRLGHGELKDWSILLGECSLQTISRQLKETCKMCGISAADSPSILSACLVAMEPQGSFIVMPDAVTMGSVFGRNTALNLQTSQLSTPQDASCTHILVFPTSATTQVSPANYHNEEDMLDLPFLDDMDNDIGILITGNLHSPPNSSPGSPIGAGPHFQHSRSQVERLLSRETPEELKQQPLALGYYVSTAKAENLPEWFWSSCPHAQNQCPLFLKASLHHHISVSHNEDLVPARTSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPIHFTVLIQMYNMVMDFL
Length2131
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.426
Instability index56.49
Isoelectric point5.52
Molecular weight235199.12
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11147
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     187.85|      32|      32|     515|     546|       1
---------------------------------------------------------------------------
  481-  505 (29.00/ 8.49)	T..........TTP....F....HHRALPTQNEecLSQETAV..Q
  506-  538 (46.15/18.24)	QRQGTEAA..tSTP....PN..RHFQSLPSAGE..LDQMLPS..Q
  539-  571 (43.20/16.57)	PTDSPHSP.asPMP....PT..LSPQ..PPQQE..VAIPDPE.vQ
 1520- 1552 (35.47/12.17)	TPNGTSTA...PLP....PPqlSSTTSLP.AG....NSTVPTgfN
 1553- 1589 (34.01/11.34)	NCSSQNSSssvERPlgnqST..GDPE..PSQQS..IQQETPE..N
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.33|      25|      28|    1110|    1134|       2
---------------------------------------------------------------------------
 1110- 1134 (49.22/30.39)	NFDSC.CICACNLNIK...GADVGIYIPD
 1137- 1165 (38.11/21.80)	NEDQYrCTCGFSAIVNrrlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.75|      28|      31|     990|    1019|       3
---------------------------------------------------------------------------
  316-  337 (31.20/ 8.25)	PSPCRM..PlTP..PTSP..EQIAPGDG...
  990- 1019 (45.89/19.87)	PDYLQLNTP.QTNTPLAPcsTAPASNGGTGG
 1024- 1051 (51.66/18.08)	PATPRFSVP.TPRTPRTP..RTPRGGGGASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.09|      25|      28|      57|      84|       5
---------------------------------------------------------------------------
   60-   84 (47.78/31.96)	FIRCLQANLLCVWRREVKPDRKELW
   86-  110 (51.31/27.13)	FWWGDEPNLGDVIHHELHMDEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.24|      15|      28|    1784|    1810|       6
---------------------------------------------------------------------------
 1784- 1798 (28.28/31.33)	ELLETCVVNIH...VPNR
 1813- 1830 (27.96/ 7.60)	KLWEWCVEIIQttsVPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.90|      26|      28|     769|     794|       7
---------------------------------------------------------------------------
  769-  794 (41.61/27.02)	DPRQDRGIAAS.LTQVKDLAPSLNDLD
  798-  823 (40.75/26.26)	DNSEDEDLAGS.PGTRAMKVPSLGSED
  829-  853 (29.53/16.42)	DARMTVAYSATdLQRMFPTPPSLEQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.00|      24|      27|    1455|    1478|       8
---------------------------------------------------------------------------
 1455- 1478 (44.38/32.91)	SCEDMDNQARLQLFAQ..TCRQHLAP
 1481- 1506 (35.62/24.52)	STLQLDNSLLLPPKKQpsTVQTNLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.80|      12|      27|     262|     273|       9
---------------------------------------------------------------------------
  262-  273 (20.68/12.51)	DFPAAVEVIVAG
  289-  300 (21.12/12.96)	DLPLSSSVGGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.67|      16|      26|    1301|    1322|      10
---------------------------------------------------------------------------
 1301- 1322 (22.38/24.81)	VRMLLSLQPFlqdaiqKKRTGR
 1330- 1345 (32.29/19.13)	VQGPLTWQQF......HKMAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.01|      14|      26|    1362|    1375|      11
---------------------------------------------------------------------------
 1362- 1375 (25.28/19.30)	LLVGY....DKDFLTIAP
 1385- 1402 (21.73/15.20)	LLEPYggqrDVGYLVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.89|      20|      26|    1616|    1641|      12
---------------------------------------------------------------------------
 1616- 1641 (30.91/28.20)	MVDPFTYTVDEDChpgnywMLGLIRC
 1645- 1664 (35.99/16.89)	MLESLPEPIRNAC......ILQVVPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.00|      25|      26|     918|     943|      13
---------------------------------------------------------------------------
  433-  456 (29.71/12.85)	.PSGC...RPSsVTQP.sMGGIPTSCSAS
  918-  943 (40.16/24.87)	VPSCQSFvGTS.MFAP..LKSLPSQCLLS
  946-  972 (43.13/22.71)	IPDACVY.RPS.WAAPpkMQHLPLPPATS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.70|      29|      33|    2008|    2040|      14
---------------------------------------------------------------------------
 2012- 2040 (56.68/33.49)	KQQPL....ALGYYVSTAKAENL.PEWFWSSCPH
 2043- 2076 (45.02/17.84)	NQCPLflkaSLHHHISVSHNEDLvPARTSQRVPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.17|      31|      32|    1226|    1257|      15
---------------------------------------------------------------------------
 1226- 1257 (53.34/32.73)	QGVTLSDRPSWN.YDR..VRAESSDAWPEClNALE
 1258- 1291 (46.83/24.49)	QGRQYVDNPTGGrVDEalVKSATFHLWPHS.NVLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.89|      39|     447|    1404|    1449|      21
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 1404- 1449 (54.63/65.32)	NCALldgaKAFFRDLSAVYEMCRL.GEHRPicKVLSDGIIKIsRPAG
 1853- 1892 (65.26/49.17)	ECSL....QTISRQLKETCKMCGIsAADSP..SILSACLVAM.EPQG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11147 with Med13 domain of Kingdom Metazoa
Unable to open file!