Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MATFGMANERLRALEEIEREIAAILLNAGNAILELSKEKPNERMLDKQAAQFTASVQRVESELSGQIRYLTQVATGQPHEGSSYSARKDGTMALNRIDYSRVKLAELSRTCEQMLEQP |
Length | 118 |
Position | Head |
Organism | Xenopus laevis (African clawed frog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.502 |
Instability index | 38.40 |
Isoelectric point | 5.49 |
Molecular weight | 13214.85 |
Publications | PubMed=27762356 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11145 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) LSKEKP 2) QFTASVQRVESELSGQIRYLTQVATGQPHEGSSYSARKDGTMALNRIDYSRVKLA | 35 51 | 40 105 |
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