<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11144

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVAYICEWDKRPRTSHCPSIPLVCAWSCRNLIAFTTDQRNEEEKDITNLIHILDTEHPWDVYSINSGHQEVITSLEWDQSGSHLLSADADGRIKCWGMTDHLANSWQSLVGSEVDGDPIVALSWLHNGVKLALHVEKSGVSSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPNGQVLTATESLCRLRCRVALADIAFTGGGNIVVATCDGSSTSPVQFYKVCVSVVSEKCKIDTEILPSLFMRCTTDPARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPLNNIFQQLSPAVSDKQPMILKWRILSATNELERVSAVALPKLPISLTNTDIKVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEPSLKRQRSPTPCIHFKALQMSWTSLALVGLDTQGKLSILRVSPSMGHSLDMSTSLRHLLFLLEYCMVTGYDWWDILLHVQPGMVHNLVDKLNEEYTRQNAALQQVLSTRILAMKASLCKLSQNTVTRVCDYHAKLFLISISCTLKSLLRPHVLNTPDKSPGDRLTEICSKFTDTDIDKVMINLKTEEFVLDMPTLQSLQQLIQWLGDFVLYLLASLPNQGLSVRPGHSFLRDGASLGTLREMMVMIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTRLWLCCRDESHPCDPDESLIDECCLLPSQLLIPNMDWLPLGNGIISRLQSKLPLRLQFGKTPGAHSYASVHYEAYTRSPTQPKIDHLRRLHLGTFPTEPCKSCTRCGCVTMLKSPNKATAVKQWEQRWIKTCLCGGLWRKMPHTYS
Length828
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.051
Instability index48.75
Isoelectric point8.19
Molecular weight92539.40
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11144
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     342.00|     112|     347|     298|     424|       1
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  298-  423 (167.54/143.47)	WSLRKEG.LPlnnIFqqlsPAVSDKQ.PMILKWRILSATNELERvsAVALPKLP.ISLTNTDIKVASETkFYPGLGLaLAFHDGnvqIVHRL.SLQPMAVLYGSSLRPSEEPSLKRQ...RSPT.PCI.HFKALQ
  653-  773 (174.46/110.77)	WGLLKPScLP...VY....TATSDTQdSMSLLFRLLTRLWLCCR..DESHPCDPdESLIDECCLLPSQL.LIPNMDW.LPLGNG...IISRLqSKLPLRLQFGKTPGAHSYASVHYEaytRSPTqPKIdHLRRLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.34|      24|      69|       8|      34|       2
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    8-   34 (41.41/31.71)	EWDKRPrtSHCPSIP....LVCaWSCRNLIA
   77-  104 (41.93/22.13)	EWDQSG..SHLLSADadgrIKC.WGMTDHLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.98|      33|     188|     428|     460|       3
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  428-  460 (55.36/34.55)	SLALVGLDTQGKLSILRVSPSMGHSLDMSTSLR
  619-  651 (58.62/37.02)	SLPNQGLSVRPGHSFLRDGASLGTLREMMVMIR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11144 with Med16 domain of Kingdom Metazoa
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