<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11141

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYIWQGPNSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDERPGRRELWIFWWGEDPNFADLIHHDLADEEDGIWDNGLSYECRTLLFKAIHNLLERCLMNRNFVRIGKWFVKPYEKDEKPVNKSEHLSCSFAFFLHGDSNVCTSVEINQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKMSDSSTKKLIGEWKQFYPISSSVKESSEEKHEEMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQSDLPVPSTVGSSHCSNTCLGVQVPASSRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFPAVSDCFNSDITSHHGGMIPTKLANHVVDRVWQECNMNRAQNKRKFSSNGVCEDESPEKTASWDFVESTQRTNCGCSRHKNLKQRNLNQPGQPVTASTQQQATQKHKTNDKQEKSDKPQKRPLTPFHHRASLSDDVNIEADGASQRLGIRSQDTRGRFSNIRSSDIAKTPQMHNEMASSPPPPPLSPHPCEVLDEGAETIKNPSTPHSQHFYQMPTPDPLIPVKAIDERIDSLPQAFASAFPEVLEPTMYVGTAVRLEAGETDNTWKYYKVPKKKESEFNPPPLPNDKFREDNCGSFGKENISVTELMVHGKKPLKISEELLHKYQSKNQYIPAAVYDTDQESDPYTFVDDDVEFTFSDTKKERQISDRDVGKKQKPEDVISSVSVLPQEGEDAMSLFSPSVKSDEQRSEAHARTASTSLFHETDLVVSYTDLDNLFNSDEDELTPGSKRALNADDKANSKESKPGNLDPLSCISTADLHKMYPTPPSLEQHFMGFSPMNMNSKDYGNMDTTPGSLLDGSNFCIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPETCQVLVGCSMFAPLRTLPSQCVPAIKLPDECIYRPSWTVGKLELIPPVPSMPFIKDGNIPSVGSAMDQDYVQTYTPQTHTPFGMSSSAPPSNGGAGILPSPATPRFSAPTPRTPRTPRTPRGGGGPASVQGSVKYDNSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRQTDGGKEVEKRFEALRAAGGDHGVLRDPEKMPDELILLLHDQCTNLFSPFGTSDQEPITKTGTVCYSARVEEQDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSTCLHRWSKRNAVDASMQCSQDILRMLLSLQPVLQDAVQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVVCPENEALLNGAKSFFRDLTAMYESCRLGQHRAICKQLTDGIMKVGSTAAKKLSEKPVAEWFSQASNGNSEAYCKLRLYAQVCRYELGPYLASQPLDNSLLCQPNLAPPVSQAVSVQPASSSTPGNPSTPSSLNSSAAISASTVTPNTLPQATATGASSTSNVTGGMAGNKPTSFPPYGSINSTTNSIPAQVNSVQNNQAGQQTQQTTLQQNTGMSSEQSAAAAAAAAEITESTMDRDKVGVPTDGESHAITYPPAIVVYIVDPFTYESKDEDSNASSVWMLGLLRCFLEMLHILPPHLRNTVSVQIVPCQYFLQPVRQEDRQIYTQHLKSLAFSVFTQCRRPLPASTNVKTLTGFGPGLAIENALKSPERPDCIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWVLASCTDLYGELLETCIINIDVPNRARRKKGSARRCGLQKLWEWCQGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISASDSPTILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLTMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENIDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINNLPTSPTGSQGHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTYILQQPLALGYFISTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQLYNFIMNTL
Length2165
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.08
Grand average of hydropathy-0.425
Instability index50.98
Isoelectric point5.43
Molecular weight238979.47
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11141
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.79|      58|     201|     319|     380|       1
---------------------------------------------------------------------------
  319-  380 (89.76/77.24)	MSSVTLTPPTSPEEVQTVDaQSAQKwVKFPAV..SDCFNSDITShhGGMIPTKLANHVVDRVWQ
  523-  582 (104.04/69.90)	MASSPPPPPLSPHPCEVLD.EGAET.IKNPSTphSQHFYQMPTP..DPLIPVKAIDERIDSLPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.45|      22|      28|     976|     997|       2
---------------------------------------------------------------------------
  948-  969 (25.85/ 9.38)	.PVPSMPF.IKDGNIPS.VGSAmdQ
  976-  997 (41.86/20.25)	TPQTHTPFGMSSSAPPS.NGGA..G
 1004- 1026 (35.74/16.09)	TPRFSAPTPRTPRTPRTpRGGG..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     285.94|      75|     713|    1277|    1355|       3
---------------------------------------------------------------------------
 1168- 1205 (42.66/18.32)	..........................................AAGGDHGVLR..DPEKMPDELIL......LLHDQCTNLFSPFGTSD.
 1277- 1355 (128.05/86.79)	DILRMLLSLQPvlqDAVQKKRTVRSwGVQG..PLTWQQFHKMAGRGSYGTDE..SPEPLPIPTFL......VGYDYDFLVLSPFALPYW
 1990- 2071 (115.24/66.59)	DLLDTGDDLDP...DIINNLPTSPT.GSQGhsPGSHYPHGGDAGKGQ.GTDRllSTESHDEVTYIlqqplaLGYFISTAKAGP..LPDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.48|      30|     713|    1071|    1104|       4
---------------------------------------------------------------------------
 1070- 1103 (44.07/34.30)	SLYVNLILSESVMNLFKDCnfdSCCICVCnMNIK
 1104- 1133 (54.41/29.29)	GADVGVYIPDPTQEVQYRC...TCGFSAV.MNRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.99|      55|      56|    1478|    1532|       6
---------------------------------------------------------------------------
 1436- 1475 (50.22/22.48)	.................SQASNGNSEAYCKLRLYAQVCRYELGPYLASQPLDNSLLC
 1478- 1532 (87.71/45.10)	NLAPPV..SQAVSVQPASSSTPGNPSTPSSLNSSAAISASTVTPNTLPQATATGASS
 1535- 1590 (83.06/42.30)	NVTGGMagNKPTSFPPYGSINSTTNSIPAQVNSVQNNQAGQQTQQTTLQQN.TGMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     292.77|      96|     483|     153|     257|       7
---------------------------------------------------------------------------
  153-  257 (148.12/117.90)	PVNKSEHLSCSfAFflhGDSNV.CTSVEINQHQPVYlLSEEHLTLAQQSNS..PFQVILS.....PFglngTLTGQSFKMSDSSTKKL.......IGEWKQFYPISSSVKESSEEKHEEM
  632-  742 (144.65/89.89)	PNDKFREDNCG.SF...GKENIsVTELMVHGKKPLK.ISEELLHKYQSKNQyiPAAVYDTdqesdPY....TFVDDDVEFTFSDTKKErqisdrdVGKKQKPEDVISSVSVLPQEGEDAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.97|      46|     481|     387|     440|       8
---------------------------------------------------------------------------
  387-  440 (69.97/59.23)	AQNKRKFsSNGVCedeSPEKTASWDFVESTQRTNC....GCSRHKNLkqRNLnqPGQ..P
  873-  924 (79.00/43.51)	AQFKIEV.DEGFC...SPKPSEIKDFSYVYKPETCqvlvGCSMFAPL..RTL..PSQcvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.93|      43|     318|     462|     515|       9
---------------------------------------------------------------------------
  462-  515 (55.52/59.19)	SDKPQkrpLTPFHHRASLSDDvniEADGASQRLGirSQDTrgrFSNIRSSDIAK
  786-  828 (75.41/44.48)	SDEDE...LTPGSKRALNADD...KANSKESKPG..NLDP...LSCISTADLHK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11141 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMDQDYVQTYTPQTHTPFGMSSSAPPSNGGAGILPSPATPRFSAPTPRTPRTPRTPRGGGGPASVQGSV
2) CGCSRHKNLKQRNLNQPGQPVTASTQQQATQKHKTNDKQEKSDKPQKRPLTPFHHRASLSDDVNIEADGASQRLGIRSQDTRGRFSNIRSSDIAKTPQMHNEMASSPPPPPLSPHPCEVLDEGAETIKNPSTPHSQHFYQMPTPDPLIPVKAI
3) FNSDEDELTPGSKRALNADDKANSKESKPGNLDP
4) PDIINNLPTSPTGSQGHSPGSHYPHGGDAGKGQGTDRLL
5) QAVSVQPASSSTPGNPSTPSSLNSSAAISASTVTPNTLPQATATGASSTSNVTGGMAGNKPTSFPPYGSINSTTNSIPAQVNSVQNNQAGQQTQQTTLQQNTGMSSEQSAAAAAAAAEI
966
421
784
2000
1485
1034
573
817
2038
1603










Molecular Recognition Features






MoRF SequenceStartStop




1) WKYYKVPKKK
613
622