<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11139

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPTVQLENSQLVVSGGPTSVPQPPPPGSVVPSTAATHGYRLSTLIEFLLQRTYQELNVLADLLPRKSDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISNFLDQQTILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVDRYLAGKFLTLTVWNQQVLGRKTGTASVHKVTIKIDENDCSKPLQISHEPPLPICDSKLMERAMRIDHLSTEKLLIDSVHARSHQKLQELKIILKSFNPNENSFVETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMMYGFDQTTLDDMEKSINDDMKRIIPWLLQLKFWLGQQRCRHSVKHLPTVCSETLHLTNYATHPVSNLSRHTLYIKLTRLPQYYIVVEMFEVPGSPTELEYAYHFLSVSHTEGEENPPTAILLQKFKPNVEELAVDGSCRKQGKAGNKRKLSGEQGSPESKKPKRTGEICAFNKILAHFVAMCDSNMPFIGLRMELSNMEIPHQGVQIEGDGFSHAIRLLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNRTWVAELLFANCPLNSTTSREQGPTRHVNLTYENPLSEPVGGRKVVEMFLNDWNSIARLYNCVLEFSRSLQDIPAHLNMFCEVRVYNYRKLILCYGPTKGSSISIQWNSIHHKFHISLGTVGPNSGCSNCHNIILHQLQEMFNKVPNVVQLLQVLYDTQAPLTSINKLPTVPMLGLTQRINTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLLSQLQPQGQQTQQFAKQIGASGAYPLTSPPSSYHNTVTPSPSMMHSQSPGNLQSSPSGVLRAPSPASFGPTPSPSSLGISMVPTSNFASPHGALDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDVSYSPRAGTSSQAMPTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPGLAPALAGSYLCSPLERFLGSVNMRRHLQRIIQQETLQLINSNEPGVIMFKTDVLKCRVALNPTTNQTLQLKVTPENAGQWKPEELQVLERFFETRVAGPPFKANTLIAFTKLLGAPAHILRDCVHIMKLELFPDQTTQLKWNVQFCLTIPPSAPPIAPSGTPAVVLKSKMLFFLQLTQKTSAPTDAVSIIVPIIYDMASGTTQQAEIPRQQNSSVTAPITVSNILKRFAEMNPPRPGECTIFAAVRDLMANLTLPPGSRP
Length1442
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.210
Instability index53.11
Isoelectric point8.74
Molecular weight160496.34
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11139
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     263.72|      45|      48|    1041|    1085|       1
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  943-  977 (34.48/12.50)	.....................FYP..APGLKT..F..LNMFVDSNQ......DARRRSVneddNPPSP
 1005- 1035 (38.44/14.85)	GASGAypLTS...P..P.S.SYHNtvTPSPS..........................MM....HSQSP
 1041- 1085 (84.95/42.46)	SPSGV..LRA...P.SP.A.SFGP..TPSPSS..LG.ISMVPTSNF......ASPHGAL....DPSSP
 1090- 1121 (40.30/15.95)	SPS....QRAgnwPgSP.Q.VSGP..SPAARM..PG.MS.........................PANP
 1123- 1171 (41.50/16.67)	.......LHS...P.VPdV.SYSP..RAGTSSqaMP.TNMPPPRKLpqrswaASIPTIL....THSAL
 1178- 1205 (24.04/ 6.30)	SPTPG..L.A...P.AL.AgSYLC..SPLERF..LGsVNM............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     899.78|     227|     496|     139|     378|       2
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  139-  378 (373.85/259.14)	LPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVM....GDDPD..IPWRLLKLEI.LVEDKETGDGRALVHSMQinfihqlvqsrlfADEKPLQDMYNCLHSFCLSLQ...........LEVLHSQTLML.........IRERWGDLVQVDRY.LAGKF.LTL.....TVWNQQVLGRKTGTA.SVHKVTI.KIDE...............NDCSKPL.QI..............................SHEPPLPICDSKLMER
  390-  616 (242.56/150.85)	L.......LIDSVHARSHQKLQE.LKIILKSFNPNENSFVETALPTLVIPILEPCGRSECLHVFVDL..HSGMFQLMMYGFDQTTLDDMeksiNDDMKriIPW.LLQLKFwLGQQR.....................................CRHSV...KH...........LPTVCSETLHL.........TNYATHPVSNLSRHtLYIKL.TRLpqyyiVVEMFEVPGSPTELEyAYHFLSV.SHTE...............GEENPPT.AIllqkfkpnveelavdgscrkqgkagnkrklSGEQGSP..ESK....
  651-  886 (283.38/177.70)	LSNMEIPHQGVQIEGDGFSH...AIRLLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNRTWVAELLFANCPLNSTTSRE................Q..GPTRHVNLTY.ENPLSEPVGGRKVVEMFL.............NDWNSIARLYNCVLEFSRSLQdipahlnmfceVRVYNYRKLILcygptkgssISIQWNS........IHHKFhISL..........GTVGPNSGCS.NCHNIILhQLQEmfnkvpnvvqllqvlYDTQAPLtSI..............................NKLPTVPMLG..LTQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     303.48|     101|    1308|       3|     113|       3
---------------------------------------------------------------------------
    3-  113 (152.16/119.05)	TVQLE.NSQLVVsggptSVPQPPPPgsVVPStaATHGYRLSTLIEFLL...QRTYQELNVLADLLPRKSDM....ERKIEIV..QFASRTRQLFVRLLaLVKWAN.NAGKVEKCAMISNFLD
 1318- 1429 (151.32/92.39)	TTQLKwNVQFCL.....TIPPSAPP..IAPS..GTPAVVLKSKMLFFLqltQKTSAPTDAVSIIVPIIYDMasgtTQQAEIPrqQNSSVTAPITVSNI.LKRFAEmNPPRPGECTIFAAVRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.36|      18|     391|     894|     916|       5
---------------------------------------------------------------------------
  894-  916 (26.19/28.54)	FSILPQSPTHIrlaFRNmyCIDI
 1291- 1308 (35.17/20.06)	FTKLLGAPAHI...LRD..CVHI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11139 with Med14 domain of Kingdom Metazoa
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