<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11138

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPTVQLENSQLVVSGGPTSVPQPPPPGSVVPSTAATHGYRLSTLIEFLLQRTYQELNVLADLLPRKSDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISNFLDQQTILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVDRYLAGKFLTLTVWNQQVLGRKTGTASVHKVTIKIDENDCSKPLQISHEPPLPICDSKLMERAMRIDHLSTEKLLIDSVHARSHQKLQELKIILKSFNPNENSFVETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMMYGFDQTTLDDMEKSINDDMKRIIPWLLQLKFWLGQQRCRHSVKHLPTVCSETLHLTNYATHPVSNLSRHTLYIKLTRLPQYYIVVEMFEVPGSPTELEYAYHFLSVSHTEGEENPPTAILLQKFKPNVEELAVDGSCRKQGKAGNKRKLSGEQGSPESKKPKRTGEICAFNKILAHFVAMCDSNMPFIGLRMELSNMEIPHQGVQIEGDGFSHAIRLLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNRTWVAELLFANCPLNSTTSREQGPTRHVNLTYENPLSEPVGGRKVVEMFLNDWNSIARLYNCVLEFSRSLQDIPAHLNMFCEVRVYNYRKLILCYGPTKGSSISIQWNSIHHKFHISLGTVGPNSGCSNCHNIILHQLQEMFNKVPNVVQLLQVLYDTQAPLTSINKLPTVPMLGLTQRINTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLLSQLQPQGQQTQQFAKQIGASGAYPLTSPPSSYHNTVTPSPSMMHSQSPGNLQSSPSGVLRAPSPASFGPTPSPSSLGISMVPTSNFASPHGSQAMPTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPGLAPALAGSYLCSPLERFLGSVNMRRHLQRIIQQETLQLINSNEPGVIMFKTDVLKCRVALNPTTNQTLQLKVTPENAGQWKPEELQVLERFFETRVAGPPFKANTLIAFTKLLGAPAHILRDCVHIMKLELFPDQTTQLKWNVQFCLTIPPSAPPIAPSGTPAVVLKSKMLFFLQLTQKTSAPTDAVSIIVPIIYDMASGTTQQAEIPRQQNSSVTAPITVSNILKRFAEMNPPRPGECTIFAAVRDLMANLTLPPGSRP
Length1381
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.193
Instability index50.69
Isoelectric point8.71
Molecular weight154306.53
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11138
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     809.21|     268|     435|     572|     911|       1
---------------------------------------------------------------------------
  139-  375 (299.64/174.12)	....................................LPSFAIPY.AIDVLTTGsyprLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEfeatltvMGddpdiPWRLLKLEILVEDKETGDGRALVHSM..QINFIHQLVQSRL.FAdeKPLQDMYNCLHSFClslQLEVLHSQTLMLIR.ERWGDLVQVD.RYLAGKF.LTLtvwnqQVLGRKTGTASVHKVTI.KIDENDCSKP..................................................LQISHEPPLPICD.SKL...........................................
  618-  911 (426.21/327.87)	PKRTGEICAFNKIL...AHFVAMCdsnmpfiglrmeLSNMEIPHqGVQIEGDG....FSHAIRLLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNRTWVAELLFANCPLNSTTSRE.......QG.....PTRHVNLTYENPLSEPVGGRKVVEMFlnDWNSIARLYNCVLeFS..RSLQDIPAHLNMFC...EVRVYNYRKLILCYgPTKGSSISIQwNSIHHKFhISL.....GTVGPNSGCSNCHNIILhQLQEMFNKVP.............................................nvvqLLQVLYDTQAPLTSINKLptVPML.....GLTQRINTAYQCFSIL..PQSPTHIRLAFRNM
 1221- 1352 (83.36/31.51)	PFKANTLIAFTKLLgapAHILRDC.................................................................................................................................................................................................................................................vhimklelfpdqttqlkwnvqfcltippsappiapsgtpavvlkskmlfFLQLTQKTSAPTDAVSII..VPIIydmasGTTQQAEIPRQQNSSVtaPITVSNILKRFAEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.46|      28|      32|    1015|    1044|       2
---------------------------------------------------------------------------
  977- 1026 (27.38/13.38)	PiggDMMD.SLL.SQLQ..PQGqqtqqfakqigasgaypltsP.PSSYHNtvTPS
 1027- 1059 (47.56/20.92)	P...SMMH.SQSPGNLQSSPSG................vlraPsPASFGP..TPS
 1060- 1094 (36.52/14.35)	P...SSLGiSMVPTSNFASPHG............sqamptnmP.PPRK....LPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.53|      31|     609|     497|     583|       3
---------------------------------------------------------------------------
  540-  573 (50.61/122.07)	IVVEMFEVPGSPTELEYayhFLSVSH......TEGEENPP
  939-  975 (50.92/ 8.35)	IVEGFYPAPGLKTFLNM...FVDSNQdarrrsVNEDDNPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.74|      23|    1247|       3|      32|       4
---------------------------------------------------------------------------
    3-   32 (32.07/22.77)	TVQLE.NSQLVVsggptSVPQPPPPgsVVPS
 1257- 1280 (39.66/13.95)	TTQLKwNVQFCL.....TIPPSAPP..IAPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.34|      14|      71|    1124|    1139|       6
---------------------------------------------------------------------------
 1124- 1139 (22.29/17.90)	PALAGSYlcSP.....LERFL
 1195- 1213 (24.05/11.81)	PENAGQW..KPeelqvLERFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.82|      29|      30|      59|      87|       7
---------------------------------------------------------------------------
   59-   87 (46.37/35.82)	LADLLPRKSD...MERKIEIVQFASRTRQLFV
   89-  120 (41.45/31.11)	LLALVKWANNagkVEKCAMISNFLDQQTILFV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11138 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLLSQLQPQGQQTQQFAKQIGAS
2) PLTSPPSSYHNTVTPSPSMMHSQSPGNLQSSPSGVLRAPSPASFGPTPSPSSLGISMVPTSNFASPHGSQAMPTNMPPPRKLPQRSWA
960
1011
1007
1098










Molecular Recognition Features






MoRF SequenceStartStop




NANANA