<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11131

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSCFVPNGASLEDCHSNLFCLADLTGIKWKRYIWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDERPGRRELWIFWWGDDPNFADLIHHDLADEEDGIWDNGLSYECRTLLFKAIHNLLERCLMNRNFVRIGKWFVKPYEKDEKPVNKSEHLSCSFAFFLHGDSNVCTSVEINQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKMSDSSTKKLIGEWKQFYPISSNVKESSEEKHEEMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQSDLPPTSSVGSSHCSNTCLGVQVPASSRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFPAVSDCFNSDTTSHHGGKIPRKLANQVVDRVWQECNMNRAQNKRKYSSNGVCEDESPEKTTSWDFVESTQRTTCVCSRHKNVKQRNLNQPGQPVTASMQQATQKHKTNDKQEKGDKPQKRPLTPFHHRASLSDDFNIEADSASQRLGIRSQDTRGRFSNIRPNDVAKTPQMHNNEMTSSPPPPPLSPHPCEVLDEGGETIKNPSTPHSQHFYQMPTPDPLIPVKAIDERIDSLPQTFASAFPEILEPTMYVGTAVRLEAGENDNTWKYYKVPKKKEAEFNPPQLPNDKLREDTSGKENIISVTELMVQGKKPLKISEELLHKYQSKNQYIPTAVLNTDQDSDPYTFVDDDVEFIFSDSKKERQITDRDVGKKHKAEDVMSNVSVLPQEGEDAMSLFSPSVKPDAQRSEAHARTASTSLFHETDLVVSYTDLDNLFNSDEDELTPGSKRALNADEKANGKELKPGNLDPLSCISTADLHKMYPTPPSLEQHFMGFSPMNMNSKDYGNMDTTPGGSLLDGSNFCIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPETCQVLVGCSMFAPLRTLPSQCVPAIKLPDECIYRPSWTVGKLELIPPVPHMPFIKDGNIPSVGSAMDQDYVQTYTPQTHTPFGMSSSAPPSNSGAGILPSPATPRFSAPTPRTPRTPRTPRGGGGPASVQGSVKYDNSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRQTDSGKEVEKRFEALRAAGGDHGVLRDPEKMPDELILLLHDQCTNLFSPFGTLDQEPITKTGTVSYSARVEEQDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSTCLHRWSKRNAIDASMQCSQDILRMLLSLQPVLQDAVQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLVGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVVCPDNEALLNGAKSFFRDLTAMYESCRLGQHRAISKQLTDGIMKVGSTAAKKLSEKPVAEWFSQAANSNSEAYSKLRLYAQVCRYELGPYLASQPLDSSLLCQPNLASPASQAVSVQPASSCTPGNPSTPSSLNSSAAASSSTVTPNNLPQAAATGSSSTANVAGGMSGNKPTSFPPYGNISSTTNSIPAQVNSVQNNQGGQQTQQTLQQNTGMSSEQSAAAAAAAAEVTESTMERDKVGVPTDGESHAITYPPAIVVYIVDPFTYENKDEDSNASSVWMLGLLRCFLEMSHILPPHLRNTVSVQIVPCQYFLQPVRQEDRQIYTQHLKSLAFSVFTQCRRPFPASTNVKTLTGFGPGLAIENVLKSPERPDCIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGELLETCIINIDVPNRARRKKGSARRCGLQKLWEWCQGLVQMSSLPWRVVIGRLGRIGHGELKDWSRLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLTMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENIDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINNLPTSPTGSQGHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQLYNFIMNML
Length2163
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.08
Grand average of hydropathy-0.440
Instability index51.90
Isoelectric point5.52
Molecular weight238956.45
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11131
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.28|      13|      15|    1026|    1038|       1
---------------------------------------------------------------------------
 1026- 1038 (21.82/12.08)	PASV.....QGSVKYDNS
 1043- 1055 (26.18/16.62)	PAST.....PSTCRPLNS
 1490- 1507 (18.27/ 8.39)	PASSctpgnPSTPSSLNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     277.79|      54|     446|     515|     569|       2
---------------------------------------------------------------------------
  278-  311 (38.90/12.18)	.....................YPaCFVLV..PQSD.LPPTSSVGSSHC.SNTCL..GVQVP
  316-  367 (69.21/27.94)	DPAMSSV.TLT.....PPTSPEE.VQTVDaqSAQKWVKFPAV..SDCFNSDTTShhGGKIP
  515-  569 (102.63/48.88)	TPQMHNN.EMTSSpPPPPLSPHP.CEVLD..EGGETIKNPSTPHSQHFYQMPTP..DPLIP
  975- 1017 (67.05/26.83)	TPQTHTPfGMSSS.APPS..........N..SGAGILPSPATPR....FSAPTP.rTPRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.87|      63|     446|     680|     745|       3
---------------------------------------------------------------------------
  680-  745 (104.62/86.31)	AVLNTDQDSDPYTFVDDDVEFI..FSDSKKE...RQITDRDVGKKHkaeDVMSNVSVLPQE.....GEDAMSLFSP
 1127- 1199 (96.25/71.01)	AVMNRKFGNNSGLFLEDELDIIgrQTDSGKEvekRFEALRAAGGDH...GVLRDPEKMPDElilllHDQCTNLFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     228.79|      71|     482|     885|     958|       6
---------------------------------------------------------------------------
  885-  958 (122.20/94.99)	PKPSEiKDFSY.VYKPETCQVLVGC.SMFAPLRTLPSQCV....PAI..KLPDECIYRPSWTVGKLELiPPVPHMpFIKDGN
 1361- 1439 (106.58/69.54)	PYGSQ.RDIAYvVVCPDNEALLNGAkSFFRDLTAMYESCRlgqhRAIskQLTDGIMKVGSTAAKKLSE.KPVAEW.FSQAAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.66|      31|     996|     459|     496|       7
---------------------------------------------------------------------------
  201-  232 (49.04/24.50)	NSPFQVILSPFGLNGTLTgQSFKM.SDSSTKKL
  462-  493 (50.62/35.71)	DKPQKRPLTPFHHRASLS.DDFNIeADSASQRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11131 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMDQDYVQTYTPQTHTPFGMSSSAPPSNSGAGILPSPATPRFSAPTPRTPRTPRTPRGGGGPASVQGSV
2) AVSVQPASSCTPGNPSTPSSLNSSAAASSSTVTPNNLPQAAATGSSSTANVAGGMSGNKPTSFPPYGNISSTTNSIPAQVNSVQNNQGGQQTQQTLQQNTGMSSEQSAAAAAAAAEVTESTMERDKVGVPTDGE
3) CVCSRHKNVKQRNLNQPGQPVTASMQQATQKHKTNDKQEKGDKPQKRPLTPFHHRASLSDDFNIEADSASQRLGIRSQDTRGRFSNIRPNDVAKTPQMHNNEMTSSPPPPPLSPHPCEVLDEGGETIKNPSTPHSQHFYQMPTPDPLIPVKAIDE
4) DPDIINNLPTSPTGSQGHSPGSHYPHGGDAGKGQGTDRLLSTESHD
5) FNSDEDELTPGSKRALNADEKANGKELKPGN
6) PQEGEDAMSLFSPSVKPDAQRSEAHARTAST
965
1485
421
1997
782
733
1033
1618
575
2042
812
763










Molecular Recognition Features






MoRF SequenceStartStop




NANANA