<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11129
Description |
Mediator of RNA polymerase II transcription subunit 20 |
Sequence | MGTPGQAGKLLYVMHNSEYPLSTFALFENGPCLVADLNLDVLMVKLKGFFQNAKANKMETRGTRYQYCDFLVKIGTVTVGQSGRGITVEVDYCPCAVPGDCWNLMMEFMQSFMGSHAPSVPPVFSAKHDPLYTPADTMVQYMELLNKIRKQQVTVAGMR |
Length | 159 |
Position | Head |
Organism | Xenopus laevis (African clawed frog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia>
Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.035 |
Instability index | 30.40 |
Isoelectric point | 7.62 |
Molecular weight | 17687.47 |
Publications | PubMed=27762356
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364152
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP11129
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 104.84| 31| 71| 53| 83| 1
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53- 83 (55.10/36.47) AKANKMET.RGTRYQYCDFLVKIGTVTVGQSG
126- 157 (49.74/32.37) AKHDPLYTpADTMVQYMELLNKIRKQQVTVAG
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