<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11127

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPTVQLENSQLVVSGGPTSVPQPPPPGTVVPSAASHGYRLSTLIEFLLQRTYQELNVLADLLPRKSDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISNFLDQQTILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQATLQQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDSFCLSLQLEVLHSQTLMLIRERWGDLVQVDRYLAGKFLTLTVWNQQVLGRKTGTASVHKVTIKIDENDCSKPLQISHEPPLPACDSKLMERAMRIDHLSIEKLLIDSVHARSHQKLQELKTILKSSNPNDNSFVETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMMYGFDQTTLDDMEKSINDDMKRIIPWLQQLKFWLGKQRCRHSVKHLPTVCSETLHLTNYATHPISNLSRHTLYIKLTRLPQYYIVVEMFEVLGSPTELEYAYHFLSVNHTEGEDNPPTALVLQKFKPNVEELAVDGACRKQGKAGSKRKLSGEQGSPEAKKPKRTGEICAFNKILAHFVAMCDSNMPFICLRMELSNMYIPHQGVQIEGDGFSHAIRLLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNRTWVAELVFANCPLNSTASREQGPTRHVNLTYENPLSEPVGGRKVVEMFLNDWNSIARLYDCVLEFSQSLQDIPAHLNMFCEVRVYNYRKLILCYGPTKGSSISIQWNSIHHKFHISLGTVGPNSGCSNCHNIILHQLQEMFNKFPNVVQLLQVLYDTQAPLTSINKLPTVPMLGLTQRINTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLLSQLQPQGQQTQQFTKQMGASGAYPLTSPPSSYHNTVTPSPSMLHSQSPGNLQSSPSGALRAPSPASFGPTPSPSSLGISMVPNSNFASPHGALDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSNQSMPTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPGLAPALAGSYLCSPLERFLGSVNMRRHLQRIIQQETLQLINSNEPGVIMFKTDVLKCRVALNPTTNQTLQLKVTPENAGQWKPEELQVLERFFETRVAGPPFKANTLIAFTKLLGAPAHILRDCVHIMKLELFPDQTTQLKWNVQFCLTIPPSAPPIAPSGTPAVVLKSKMLFFLQLTQKNSAPTDAVSIIVPIIYDMASGTTQQAEIPRQQNSSVPAPITVSNILKRFAEMNPPRPGECTIFAAVRDLMANLTLPPGARS
Length1405
PositionTail
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.07
Grand average of hydropathy-0.219
Instability index54.24
Isoelectric point8.74
Molecular weight156033.11
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11127
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     168.43|      30|      32|     978|    1007|       1
---------------------------------------------------------------------------
  978- 1007 (60.38/25.06)	P.PSSYHNTVTPSPSML.H.SQSPGNLQSSPSG
 1012- 1041 (42.45/15.61)	PsPASF.GP.TPSPSSL.GiSMVPNSNFASPHG
 1044- 1066 (36.46/12.45)	D.PSS......PYTMMS.P.SQRAGNWPGSPQ.
 1117- 1142 (29.14/ 8.59)	P.QRSWAASI...PTILtH.SALHVLLLPSP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.80|      13|      66|    1077|    1089|       2
---------------------------------------------------------------------------
 1077- 1089 (26.53/14.14)	PGMSP..ANPSLHSP
 1097- 1109 (21.42/ 9.79)	PRAGT..SNQSMPTN
 1144- 1158 (19.85/ 8.45)	PGLAPalAGSYLCSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     409.73|     133|     357|      14|     158|       3
---------------------------------------------------------------------------
   14-  158 (201.18/187.51)	SGGP..TSVPQPPPPGTVVPSAASHGyRLSTLIEFL.LQRTYQELNVLADLLPRKSDMERKIEivqfaSRTRQLFVRLLALVKWannAGKvEKCAMISNFLD...QQTILFVDTADR.LASLARDALV..HARLPSFAIPYAI.DVLttGSYPRL
  375-  517 (208.55/156.69)	SSNPndNSFVETALPTLVIPILEPCG.RSECLHVFVdLHSGMFQLMMYGFDQTTLDDMEKSIN.....DDMKRIIPWLQQLKFW...LGK.QRCRHSVKHLPtvcSETLHLTNYATHpISNLSRHTLYikLTRLPQYYIVVEMfEVL..GSPTEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.63|      29|     396|     845|     879|       5
---------------------------------------------------------------------------
  845-  879 (40.05/51.05)	GLTQRINTAYqCFSILPQSPTHIrlaFRNmyCIDI
 1243- 1271 (54.58/40.37)	GPPFKANTLI.AFTKLLGAPAHI...LRD..CVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.64|      18|     355|     937|     962|       6
---------------------------------------------------------------------------
  168-  185 (31.87/10.92)	PPDPITKSEKQATLQQLN
  937-  954 (32.77/11.63)	PPSPIGGDMMDSLLSQLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11127 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLLSQLQPQGQQTQQFTKQMGASGAYPLTSPPSSYHNTVTPSPSMLHSQSPGNLQSSPSGALRAPSPASFGPTPSPSSLGISMVPNSNFASPHGALDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSNQSMPTNMPPPRKLPQRSWA
923
1122










Molecular Recognition Features






MoRF SequenceStartStop




NANANA