<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11105

Description Uncharacterized protein
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDAKQKEDELTALNVKQGFNNQPAVSADEHGSAKNVNFNPAKISSNFSSIMSEKLRCNTLPDTGRRKPQVNQKDNFCLVTARTQSSINTWFSDLAGTKPLTHLAKKVPIFGKKEEVFGFLARFSVPVMRAAWLIKMTCAYYAAITETKVKKRHVMDPIIEWTQIITRYLWEQLQKIADYYRPALGGCSSPPGPMPLEVEVALKQWEYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRQGEDELLKLLLPLLLRYSNSLVQSAYLSRRLAYFCTRRLAQLLEGSGSHTGHLMTAQTGTALPPAPAPPPPSGSAPTSPFSDLLQCPQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDNRIKTGSPLDHLPIAPSSLPMPGGNSAFTQQVRRKLRDMEQQIKERGRSVEVRWSFDKCQEATAGFPIGRVLHTLEVLDSHSFEKSDFSNNLDSLYNRIFGLGLGKDGHEISPDDDAVVTLLCEWAVSCKRYGHHRALVVAKLLEKRQAEIEAERCGDSEAVDEKGSVSSGSLSALSAPPVFQEVLLQFLDTQAPMLTDPANENERVEFYNLVLLFCELIRHDVFSHNMYMCTLISRGDLGLDPHAPRPRSPYEDPSDDTDRKEGEANSSIKLEDTTLSETMDIDHGSGALFEDMEKSEFPMFSPAMRCEGRSPGPEDGDRDSRHTVKVMNGEGPLSALYDQPRHIQYATHFPIPQEESCSHECNQRLVVLYGVGRQRDDARHIIKKITRDILKVLNRKSTSETDEGQRRRRAKPEAFPTAEEIFCRFQLLSHFDQHQVTAQVSRNVLEQITSFALGLSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSSLVGSYTLGLCLCIVAVLRHYHTCLILNQEQTAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEQEFMLDTIINPSGHSVNCGMLGKLLSDSPTNRYSFVCNALVHVCAGDHDTDRVNDIAILCAELTGSCKALSSEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILVARQCLLLEDLIRCAAIPSLLNAACSEQDSEAGARLTCRILLHLFKTPQLNPCEPDGSKPTAGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELRGSGFSHPTGTDNTSEEDLATRRAGGRPVSIETASLDEYAKYVLRSICQQEWVGERCVRSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLNDTEQGDNPQRQRIKHILQNLDQWTMRQSALELQLMIKQTPSNEMNTLLENIAKATIEVFQQSAENACVAPSNSIALSNATSSNTPPNSKTKPVLSSLERSGAWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLFGQVQQIVSNWREDQYQDDCKTPQLLHDVLKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGIKQSAPLSWGWFGTVRVDRRVSRMEEQQRLLLYHTHLKPKPRNYYLENLPLPPEDEEPPTPTSIEPDKKVTETLKVDKSGVGGTVNTDERKKPSKPKREKKRNMAQSKVEEFPLGPGRPVPYGMVPTDLLHTQGAGMSRLPYAAQTMYAQNQPLPPGGPRLDNSYRPNRMTMVKVPTRPQYGSGVTQPGMMDSYKPVMYRPQPPIPQGQLLRQQLQAKLAQGMMPQPVRQMSQAPSYGSMQPTQGYTSYSSHMSLQQHPPPSQAGALVPPPYSTQQYPGSLPPSGGALLDPVRQMQQRPSGYVHQQASGFSHGASGGQRFPHQQMTQTGMMQSMGHLTTQPVTGAIRPQMLPEQQQQQQQQQQYLRQQQLLRQQQQQQQQQQQQQQNQAPPQQQAPPQPPPQQVPTVPQSQTQGQPPGLGMQTLQFQRQGLQQTQQQQQTAALVRQLQQQLSSTQPQQNSNPFGRYP
Length2142
PositionKinase
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.06
Grand average of hydropathy-0.464
Instability index53.79
Isoelectric point6.79
Molecular weight239241.49
Publications
PubMed=27762356

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11105
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.70|      18|      18|    2021|    2038|       1
---------------------------------------------------------------------------
 1877- 1898 (23.30/ 6.13)	QPP.............IPQGQ....LLRQQLQaklaQGM
 1931- 1952 (26.87/ 8.30)	QQH.............PPPSQagalVPPPYST....QQY
 2005- 2035 (24.52/ 6.86)	MMQsmghlttqpvtgaIRPQM....LPEQQQQ....QQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     261.37|      73|     337|    1725|    1801|       2
---------------------------------------------------------------------------
  326-  353 (29.70/ 7.57)	...............................................................................................LPPA.PAPPPPSGSAPTSPFSDLLQCPQH
  359-  407 (50.25/18.94)	GLSCMLQSIVL................CCPSalvwHYSLTDNRIKTGSPLDHLPIAPSSlPMPGG...........................................................
 1685- 1754 (85.14/39.13)	GWFGTVRVDRRvsrmeeqqrlllyhthLKP.....KP.....RNY...YLENLP.........................................LPPEDEEPPTPTSIEPDKKVTETLKVDKS
 1755- 1850 (96.28/51.18)	GVGGTVNTDER................KKPS....KPKREKKRNMAQSKVEEFPLGPGR.PVPYGmvptdllhtqgagmsrlpyaaqtmyaqnqpLPPGG..PRLDNSYRPNR..MTMVKV...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     416.25|     114|     344|     600|     722|       3
---------------------------------------------------------------------------
  600-  716 (196.14/122.44)	CELIRHDVFSHNMYMCTlISRGDLGL.DPHAPRPRSPYEDPS...DDTDRKEGEANSSikLEDTTLSET.MDIDHG...S.GALFEDMEKSEFPMFSPAM..RCEGRSPGPEDGDRDS..RHTVKVMNGE
  987- 1058 (81.20/41.94)	.......................................EPS...DSNMLWEQEF.....MLDTIINPSgHSVNCG...MlGKLLSDSPTNRYSFVCNALvhVCAG......DHDTDR..VNDIAILCAE
 1078- 1184 (138.92/82.84)	CCSSNNGTCGFNDLLCN.VDVSDLSFhDSLATFVAILVARQClllEDLIR..CAAIPS..LLNAACSE..QDSEAGarlT.CRILLHLFKT..PQLNP.....CEPDGSKPTAGIRSScdRH........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.73|      18|      19|    2097|    2114|       5
---------------------------------------------------------------------------
 2037- 2053 (33.81/18.22)	Q......QYLR.QQQLLRQQQQQQ
 2090- 2113 (29.17/14.45)	QppglgmQTLQFQRQGLQQTQQQQ
 2114- 2133 (21.76/ 8.40)	Q.taalvR..QLQQQ.LSSTQPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.46|      21|      23|    1272|    1294|       6
---------------------------------------------------------------------------
 1272- 1294 (31.22/24.07)	RSLCEDS..NDLQDPvlSSAQAQRL
 1296- 1318 (35.24/20.88)	QLICYPHrlNDTEQG..DNPQRQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.01|      14|      18|    1642|    1659|       7
---------------------------------------------------------------------------
 1642- 1659 (12.69/25.06)	TKgNKIAGFDsIFkkEGL
 1663- 1676 (28.32/20.03)	TK.QKISPWD.LF..EGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.93|      25|     337|    1614|    1638|       8
---------------------------------------------------------------------------
 1588- 1613 (35.43/21.70)	MEEnKRAYMNLVKKLRKELGDRQSES
 1614- 1638 (43.50/28.52)	LEK.VRQLLPLPKQTRDVITCEPQGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.51|      57|     553|    1401|    1462|      11
---------------------------------------------------------------------------
 1401- 1462 (83.59/68.46)	SLERSGAWLVAPlIAKLPTSVQGHV.LKAAGeeLEKGQHLGSSSRKERDRQK..qkSMSLLSQQP
 1955- 2016 (95.92/61.27)	SLPPSGGALLDP.VRQMQQRPSGYVhQQASG..FSHGASGGQRFPHQQMTQTgmmqSMGHLTTQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.28|      23|     548|     913|     935|      14
---------------------------------------------------------------------------
  913-  935 (41.04/26.85)	TCLILNQEQTAQVFEGLCGVVKH
 1469- 1491 (40.24/26.16)	TCLKGQDEQREGLLTSLFGQVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.32|      20|      53|    1851|    1873|      21
---------------------------------------------------------------------------
 1851- 1873 (32.92/28.97)	PTRPQYGSgvTQP..GmMDSYKPVM
 1907- 1928 (36.40/19.93)	SQAPSYGS..MQPtqG.YTSYSSHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.70|      37|     905|     277|     315|      22
---------------------------------------------------------------------------
  277-  315 (57.51/50.28)	LLLRYSNSLVQSAYLSRRLAYFCTRRlAQlLEGSG.SH.TG
 1185- 1223 (54.19/37.42)	LLAASQNRIVDGAVFAVLKAVFVLGD.AE.LRGSGfSHpTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.23|      15|      18|    1534|    1548|      27
---------------------------------------------------------------------------
 1534- 1548 (25.21/17.83)	QQTTEWAVLLLDIIS
 1555- 1569 (25.02/17.64)	QSNNELFTTVLDMLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11105 with Med12 domain of Kingdom Metazoa
Unable to open file!