<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11097

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSHQHLVTCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEDFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAIYWQATNATVLEKILHGTVGYLTPRSGGQVMSLKYYVSPYDLFDDGTGASISLSEGHAVPRSLGMNVSVTIEATTSMYKLPIAPLIVGSHAMDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIEHCTGIPLIDGSHTFLPHYELVTQFELAKEKDPGPLNHNMRFYASLPGQQHCYFLNKDAPLPDGRSLQGTLLSKIPFQHPSRVPVILSLIRHQVAYNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTSALSGLTTPTSSYTSGQNSSLFNMGMKERHDSTGHGDDFNKVTQNPILTSLLQITNNTGGTLGSSPTQPQHTPPPVSSPASNTKNHPMLMNLLKDNPAQDFSNLYGGSPMERQNSSGSPRTELGASATGKPKKKRPRTGAEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPTVYQQSIPHAQSNMQRMVRIPSTDAIIPDVTDILSDIAEEASKLSGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGPGLASLNIVSGLPVDGGDGKYKMGLGADTLDFSIISTGGSKTLGGPDIQETQSRSQSPLLSNDLGKDRPQKQKVKESSNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTVSVGKPSSHGQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSSSQSKNSSQSMGKAGSSPITKHGLSSNVSNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKMSSPMKPMPGTPPSSKAKSPIGSGGQHLSGGGSNSTTKSSSGLVSSGSLSQKPNSSSSSSSSSSSSSSSSSSSSSSFCGGVSQNLHGNSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGGGGGSTGAPSHGMSSKHGMVVGEFPTKREKSEKDKSKGSGSGGSSDPSKKGGGDSKGSVGTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGDGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYGMKPESWSKSPISADPTMAMSGGSMMSSDRGVRPTPSFLMDDDDLMDVPLTL
Length1570
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.04
Grand average of hydropathy-0.639
Instability index54.56
Isoelectric point8.81
Molecular weight165680.04
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP11097
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     958.69|     102|     102|    1227|    1328|       1
---------------------------------------------------------------------------
  525-  660 (74.99/18.34)	..NL......PPA...SSPGYGMT.SAL......SglTTPTSSYTSGQNSSLFNMGMKERHDS.TG..........HGDD............FNKV.....TQNP......IL................................................TSLLQITNNTGGTLGSsptqpqhtpppvsspasntknhpmlmnllkdnpaqdfsnlygG....S..P...MERQNS....S.............GSprteL
  661-  815 (90.26/23.87)	GASA......TGK...PKKKRPRT.GAE......K..MK.NQTEDDFQRELFSMDVDSQNTIFDVG.MA...GDALDTPH............ITPA.PSQ.CGTPptvyqqSIphaqsnmqrmvripstdaiipdvtdilsdiaeeasklsgpgedcpnlgTPVRDSSSSGHSQSTL..........................................F....DTDV...FQVDGG....G.............GS....G
  816-  905 (93.04/24.87)	GENP......YPD...PVDLIVDShGS............PNSDSPNTFFNSVDFNPDLLNSQS.QS.GF...TDDLNDDS.............SQS.GDN.................................................................D.FKDFAGPGLA..........................................SlnivSGLP...VDGGDG....K.............YK....M
  908-  968 (64.56/14.57)	GADT......LDF...SIISTGGS.KTL......G..G.PDIQETQSRSQSP.......................LLSND............LGKDrPQK.QK....................................................................VKESSN..........................................G.............GGAG....G.............G......
  970- 1038 (79.96/20.14)	..................SGMQSA.G.M......E..GKSMKRSRTPSSDGKSKDKPPKRK...............KTES............DGKS.PSHiTNRP..............................................................FTPPTSTG............................................G....SKSP......GTS....G.............RS....Q
 1042- 1141 (95.75/25.86)	GMATppipkiTIQ...IPKGTVSV.G............KP....SSHGQYSSSGSSSSSSSKSHHG.HS...S..LSSSA............SGKI.KS..NKSD......GS................................................SG....MK..IGSSGG..........................................G...........MYSGQS....GqsssqsknssqsmGK....A
 1142- 1225 (105.38/29.34)	GSSP......ITKhglSSNVSNSS.GS.......K..TKPQGKPSVLMNPSLSKPNISPSHSRPSG.G....SDKMSSPM............K....PMP.GTPP......S.....................................................SKAK.........................................................SP...IGSGGQ....H.............LS....G
 1227- 1328 (171.15/53.13)	GSNS......TTK...SSSGLVSS.GSL......S..QKPNSSSSSSSSSSSSSSSSSSSSSSFCG.GV...SQNLHGNS............KGKS.PSR.NKKP......SL................................................TAVIDKLKHGVGTGGP..........................................G....SEDP...MDGGGG....G.............GS....T
 1330- 1433 (100.81/27.69)	APSH......GMS...SKHGMV.V.GEFptkrekS..EKDKSKGSGSGGSSDPSKKGGGDSKGSVGtGV...AKIIISKH............DGGS........P......SI................................................KAKV.TLQKPEG.GGD..........................................G....LRSQ...MQKNYGspliS.............GS....T
 1437- 1541 (82.78/21.16)	ERCS......PSH...NKSPAYTP.QAL............DSESESGSSSIAEKSYQNSPSSDDGG.GSgsrAQTEYSAEkhkkhkkekkrlKDKD.RDR.EKKK......SY.....................................................GMKPESWSKSP..........................................I....SADPtmaMSGG...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.96|      35|      49|     139|     175|       2
---------------------------------------------------------------------------
  139-  175 (50.06/44.05)	LKGLVNlYKVP..GDNKLETKMYLALQSLELDLTKmAAI
  189-  225 (59.89/41.75)	LHGTVG.YLTPrsGGQVMSLKYYVSPYDLFDDGTG.ASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.93|      25|      37|     242|     269|       3
---------------------------------------------------------------------------
  242-  269 (31.43/36.33)	SVTIEATTSMyKLPiAPLIVgSHAMDNK
  282-  306 (46.50/32.06)	SVDLPACFFL.KFP.QPIPV.SRAFIQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.19|      43|     100|     358|     400|       4
---------------------------------------------------------------------------
  309-  354 (34.35/17.11)	............H..C....TGIP..LI.DGSHTflpHYELVTQFelakekdpgPLNHNMRFYASLP....
  358-  399 (68.40/42.29)	............H..CYFLNKDAP..LP.DGRSL...QGTLLSKI.........PFQHPSRVPVILSLIRH
  400-  455 (46.36/25.99)	QvayntligscvK..RTMLKEDCPglLQfEVAPL...SDSCFS.I.........SFQHPVNDSLVCVVMDV
  456-  499 (52.08/30.22)	Q........dstHvsCK.LYKG....LS.DALIC...TDDFITKV..........VQRCMSIPVTMRAIRR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11097 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IFDVGMAGDALDTPHITPAPSQCGTPPTVYQQSIPHAQSNMQRMVRIPSTDAI
2) LNSQSQSGFTDDLNDDSSQSGDNDFKDFAG
3) PDVTDILSDIAEEASKLSGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFN
4) SIISTGGSKTLGGPDIQETQSRSQSPLLSNDLGKDRPQKQKVKESSNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTVSVGKPSSHGQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSSSQSKNSSQSMGKAGSSPITKHGLSSNVSNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKMSSPMKPMPGTPPSSKAKSPIGSGGQHLSGGGSNSTTKSSSGLVSSGSLSQKPNSSSSSSSSSSSSSSSSSSSSSSFCGGVSQNLHGNSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGGGGGSTGAPSHGMSSKHGMVVGEFPTKREKSEKDKSKGSGSGGSSDPSKKGGGDSKGSVGTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGDGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYGMKPESWSKSPISADPTMAMSGGSMMSSDRGVRPTPSFLMDDDDLMD
5) SYTSGQNSSLFNMGMKERHDSTGHGDDFNKVTQNPILTSLLQITNNTGGTLGSSPTQPQHTPPPVSSPASNTKNHPMLMNLLKDNPAQDFSNLYGGSPMERQNSSGSPRTELGASATGKPKKKRPRTGAEKMKNQTEDDFQRELFSMDVDSQN
703
853
757
915
549
755
882
849
1565
701










Molecular Recognition Features






MoRF SequenceStartStop




1) AQTEYSAEKHKKHKKEKKRLKDK
2) EKKKSYGMKPESWSK
3) GVAKIIISKH
4) IPKITIQIPKGT
5) LMDDDDLMDVPLTL
6) NKKPSLTAVIDKLKHGV
7) SIKAKVTLQ
8) SKHGMVVGEFPT
1486
1513
1384
1048
1557
1292
1399
1337
1508
1527
1393
1059
1570
1308
1407
1348