<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11097

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSHQHLVTCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEDFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAIYWQATNATVLEKILHGTVGYLTPRSGGQVMSLKYYVSPYDLFDDGTGASISLSEGHAVPRSLGMNVSVTIEATTSMYKLPIAPLIVGSHAMDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIEHCTGIPLIDGSHTFLPHYELVTQFELAKEKDPGPLNHNMRFYASLPGQQHCYFLNKDAPLPDGRSLQGTLLSKIPFQHPSRVPVILSLIRHQVAYNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTSALSGLTTPTSSYTSGQNSSLFNMGMKERHDSTGHGDDFNKVTQNPILTSLLQITNNTGGTLGSSPTQPQHTPPPVSSPASNTKNHPMLMNLLKDNPAQDFSNLYGGSPMERQNSSGSPRTELGASATGKPKKKRPRTGAEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPTVYQQSIPHAQSNMQRMVRIPSTDAIIPDVTDILSDIAEEASKLSGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGPGLASLNIVSGLPVDGGDGKYKMGLGADTLDFSIISTGGSKTLGGPDIQETQSRSQSPLLSNDLGKDRPQKQKVKESSNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTVSVGKPSSHGQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSSSQSKNSSQSMGKAGSSPITKHGLSSNVSNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKMSSPMKPMPGTPPSSKAKSPIGSGGQHLSGGGSNSTTKSSSGLVSSGSLSQKPNSSSSSSSSSSSSSSSSSSSSSSFCGGVSQNLHGNSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGGGGGSTGAPSHGMSSKHGMVVGEFPTKREKSEKDKSKGSGSGGSSDPSKKGGGDSKGSVGTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGDGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYGMKPESWSKSPISADPTMAMSGGSMMSSDRGVRPTPSFLMDDDDLMDVPLTL
Length1570
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.04
Grand average of hydropathy-0.639
Instability index54.56
Isoelectric point8.81
Molecular weight165680.04
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11097
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     958.69|     102|     102|    1227|    1328|       1
---------------------------------------------------------------------------
  525-  660 (74.99/18.34)	..NL......PPA...SSPGYGMT.SAL......SglTTPTSSYTSGQNSSLFNMGMKERHDS.TG..........HGDD............FNKV.....TQNP......IL................................................TSLLQITNNTGGTLGSsptqpqhtpppvsspasntknhpmlmnllkdnpaqdfsnlygG....S..P...MERQNS....S.............GSprteL
  661-  815 (90.26/23.87)	GASA......TGK...PKKKRPRT.GAE......K..MK.NQTEDDFQRELFSMDVDSQNTIFDVG.MA...GDALDTPH............ITPA.PSQ.CGTPptvyqqSIphaqsnmqrmvripstdaiipdvtdilsdiaeeasklsgpgedcpnlgTPVRDSSSSGHSQSTL..........................................F....DTDV...FQVDGG....G.............GS....G
  816-  905 (93.04/24.87)	GENP......YPD...PVDLIVDShGS............PNSDSPNTFFNSVDFNPDLLNSQS.QS.GF...TDDLNDDS.............SQS.GDN.................................................................D.FKDFAGPGLA..........................................SlnivSGLP...VDGGDG....K.............YK....M
  908-  968 (64.56/14.57)	GADT......LDF...SIISTGGS.KTL......G..G.PDIQETQSRSQSP.......................LLSND............LGKDrPQK.QK....................................................................VKESSN..........................................G.............GGAG....G.............G......
  970- 1038 (79.96/20.14)	..................SGMQSA.G.M......E..GKSMKRSRTPSSDGKSKDKPPKRK...............KTES............DGKS.PSHiTNRP..............................................................FTPPTSTG............................................G....SKSP......GTS....G.............RS....Q
 1042- 1141 (95.75/25.86)	GMATppipkiTIQ...IPKGTVSV.G............KP....SSHGQYSSSGSSSSSSSKSHHG.HS...S..LSSSA............SGKI.KS..NKSD......GS................................................SG....MK..IGSSGG..........................................G...........MYSGQS....GqsssqsknssqsmGK....A
 1142- 1225 (105.38/29.34)	GSSP......ITKhglSSNVSNSS.GS.......K..TKPQGKPSVLMNPSLSKPNISPSHSRPSG.G....SDKMSSPM............K....PMP.GTPP......S.....................................................SKAK.........................................................SP...IGSGGQ....H.............LS....G
 1227- 1328 (171.15/53.13)	GSNS......TTK...SSSGLVSS.GSL......S..QKPNSSSSSSSSSSSSSSSSSSSSSSFCG.GV...SQNLHGNS............KGKS.PSR.NKKP......SL................................................TAVIDKLKHGVGTGGP..........................................G....SEDP...MDGGGG....G.............GS....T
 1330- 1433 (100.81/27.69)	APSH......GMS...SKHGMV.V.GEFptkrekS..EKDKSKGSGSGGSSDPSKKGGGDSKGSVGtGV...AKIIISKH............DGGS........P......SI................................................KAKV.TLQKPEG.GGD..........................................G....LRSQ...MQKNYGspliS.............GS....T
 1437- 1541 (82.78/21.16)	ERCS......PSH...NKSPAYTP.QAL............DSESESGSSSIAEKSYQNSPSSDDGG.GSgsrAQTEYSAEkhkkhkkekkrlKDKD.RDR.EKKK......SY.....................................................GMKPESWSKSP..........................................I....SADPtmaMSGG...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.96|      35|      49|     139|     175|       2
---------------------------------------------------------------------------
  139-  175 (50.06/44.05)	LKGLVNlYKVP..GDNKLETKMYLALQSLELDLTKmAAI
  189-  225 (59.89/41.75)	LHGTVG.YLTPrsGGQVMSLKYYVSPYDLFDDGTG.ASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.93|      25|      37|     242|     269|       3
---------------------------------------------------------------------------
  242-  269 (31.43/36.33)	SVTIEATTSMyKLPiAPLIVgSHAMDNK
  282-  306 (46.50/32.06)	SVDLPACFFL.KFP.QPIPV.SRAFIQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.19|      43|     100|     358|     400|       4
---------------------------------------------------------------------------
  309-  354 (34.35/17.11)	............H..C....TGIP..LI.DGSHTflpHYELVTQFelakekdpgPLNHNMRFYASLP....
  358-  399 (68.40/42.29)	............H..CYFLNKDAP..LP.DGRSL...QGTLLSKI.........PFQHPSRVPVILSLIRH
  400-  455 (46.36/25.99)	QvayntligscvK..RTMLKEDCPglLQfEVAPL...SDSCFS.I.........SFQHPVNDSLVCVVMDV
  456-  499 (52.08/30.22)	Q........dstHvsCK.LYKG....LS.DALIC...TDDFITKV..........VQRCMSIPVTMRAIRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11097 with Med1 domain of Kingdom Metazoa
Unable to open file!