Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSQQQLVSCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEEFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAMYWQATNATVLEKILHGTVGYLTPRSGGQAMSLKYYISPYDLFDDITGASVSLSEGHAVPKLLGMNMSVTIEATSTMYKLPIAPLIMGSHPIDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIQHCTGIPLIDGSHTFLPHYELVTQFELAKEKDPGPLNHNMRFYASLPGQQHCYFLNKDAPLPDGRSLQGTLLSKIPFQHPGRVPIILSLIRHQVACNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQNSTHVSCKLFKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTSGSTALSGITTPTSSYTSGQISSLFNMGIKERHDTTSHGDDFNKVTQNPILTSLLQITSNTGGTLGSSPTQPQHTPPPVSSPASNTKNHPMLMNLLKDNPAQDFSALYGGSPLERQNSSGSPRTELGTLATGKPKKKRPRTGAEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPTVYQQSIPHAQSNMQRMLRIPSTDAIIPDVTDILSDIAEEASKLSGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGAGSGGENPYPDPVDLIDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGSGLASLGIVSGLPVDGGDGKYKMALGADTVDFSIISGGGSKTLVGPDIQETQSRSQSPLLGSDLGKDRPQKQKAKESSNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKAESEGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTVSVGKPSSHSQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYTGQSGQSNSQSKNSSQSMGKAGSSPITKHGLSSGVSNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKLSSPMKPMPGTPPSSKAKSPIGSGGQHLSGSGSNSTTKSSSGLVSSGSLTQKPNSSSSSSSSSSSSSSSSSSSSFSGGVSQNLHSNSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGGGGGSTGVPSHGMSSKHGMVVGEFPPKREKSEKDKSKGPGSGGSSDPSKKGGGDSKGSVSTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGDGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGNRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYSMKSESWSKSPISVDPTMVMSGGSMLSSDRGVRPTPSFLMGDDDLMDMSLTL |
Length | 1570 |
Position | Middle |
Organism | Xenopus laevis (African clawed frog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.609 |
Instability index | 53.44 |
Isoelectric point | 8.91 |
Molecular weight | 165674.43 |
Publications | PubMed=27762356 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP11094 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 973.21| 149| 149| 1008| 1156| 1 --------------------------------------------------------------------------- 522- 629 (74.57/12.13) ............................................................V..KKNLP.PASSpgyGMT.........SGSTAlSGIT......TPTSSYTSGQ.IS............................SLFNMGI......KERHDTTSHG.......................................ddfnkvtqnpiltsllqiT....S..NTG........G...TLG..SSPT............Q....PQ..HT..........PPPVssPASNTKNHPML 630- 773 (153.00/31.60) MNLL....KDNPAQD....FSA.lyGGSP......LERQNSS....GSPRTELGTLATGKP..KKKRPrTGAE...KMK.........NQTED.DFQR......ELFSMDVDSQ..N............................TIFDVGM......AG........................DALDTP.HITPA....PSqcgTP..................P....T..VYQQSIP...HA...QSNmqRMLR............I....PStdAI..........IPDV..TDILSDIAEEA 774- 948 (114.47/22.04) SKLS....GPGEDC......PN...LGTP......VRDSSSS....GHSQSTLFDTDV..F..QV....DGGA................GSGG.ENPYpdpvdlIDSHGSPNSDSPNtffnsvdfnpdllnsqsqsgftddlnddSSQS.GDndfkdfAGSG.LASLGIVS..G...lpvdggdGKYKMALGADTV....DF...S...................I....I..SGGGSKTlvgPDiqeTQS..RSQS............P........LL..........GSDL............. 949- 1061 (169.45/35.68) ...G....KDRPQKQ...............................KAKESSNGGGAGG...........GLS...GMQ..................S......AGMEGKSMKRSRT............................PS.SDGK......SKDKP......PK..R......kkaeSEGKSPSHITNR....PF...TP..................P....T..STGGSKS...PG...TSG..RSQT............P....PG..MA..........TPPI..PKITIQIPKGT 1062- 1222 (222.85/48.94) VSVG....KPSSHSQ....YSS...SGSS......SSSSSKS....HHGHSSLSSSASGKI..KSNKS.DGSS...GMK.........IGSSG.GGMY......TGQSGQSNSQSKN............................SSQSMGK......AGSSPITKHGLSS..GvsnssgsktkPQGK.PSVLMNP....SL...SK..................P....N.iSPSHSRP...SG...GSD..KLSS............PmkpmPG..............TPPS..SKAKSPIGSGG 1241- 1411 (131.11/26.17) VSSGsltqKPNSSSS....SSS...SSSS......SSSSSSS........SSFSGGVSQNL..HSN.S.KGKS...PSRnkkpsltavIDKLK.HGVG......TG..GPG...SED............................PMDGGGG......GGSTGVPSHGMSSkhG......................mvvgEF....P..................PkrekS..EKDKSKG...PG...SGG..SSDPskkgggdskgsvS....TG..VAkiiiskhdggSPSI.kAKVTLQKPEG. 1412- 1554 (107.77/20.37) ...G....GDGLRSQmqknYGSpliSGSTpkhercSPSHNKSpaytPQALDSESESGSSSIaeKSYQN.SPSS...D.D.........GGGSG.NRAQ......TEYSAEKHKKHKK............................EKKRLKD......KDRDREKKKSYS............mkSESWSKSPISV...........D..................P....TmvMSGGSML...SS...DRG..VRPT............P..................................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 101.21| 31| 48| 139| 170| 2 --------------------------------------------------------------------------- 139- 170 (48.34/31.64) LKGLVNlYKVP..GDNKLETKMYLALQSLELDLT 189- 221 (52.88/30.65) LHGTVG.YLTPrsGGQAMSLKYYISPYDLFDDIT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 42.81| 11| 51| 308| 318| 3 --------------------------------------------------------------------------- 308- 318 (23.90/13.60) QHC....TGIPLIDG 357- 371 (18.92/ 9.08) QHCyflnKDAPLPDG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.73| 20| 53| 384| 436| 4 --------------------------------------------------------------------------- 384- 409 (26.19/13.03) FQHP...GRVPIILslirhQVACNTLIgS 440- 462 (31.54/42.67) FQHPvndSLVCVVM.....DVQNSTHV.S --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GVAKIIISKH 2) IKAKVTL 3) IPKITIQIPKGT 4) KKPSLTAVIDKLKHGV 5) QTEYSAEKHKKHKKEKKRLK 6) SKHGMVVGEFPPKR | 1384 1400 1050 1293 1487 1337 | 1393 1406 1061 1308 1506 1350 |
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