<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11094

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSQQQLVSCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEEFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAMYWQATNATVLEKILHGTVGYLTPRSGGQAMSLKYYISPYDLFDDITGASVSLSEGHAVPKLLGMNMSVTIEATSTMYKLPIAPLIMGSHPIDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIQHCTGIPLIDGSHTFLPHYELVTQFELAKEKDPGPLNHNMRFYASLPGQQHCYFLNKDAPLPDGRSLQGTLLSKIPFQHPGRVPIILSLIRHQVACNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQNSTHVSCKLFKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTSGSTALSGITTPTSSYTSGQISSLFNMGIKERHDTTSHGDDFNKVTQNPILTSLLQITSNTGGTLGSSPTQPQHTPPPVSSPASNTKNHPMLMNLLKDNPAQDFSALYGGSPLERQNSSGSPRTELGTLATGKPKKKRPRTGAEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPTVYQQSIPHAQSNMQRMLRIPSTDAIIPDVTDILSDIAEEASKLSGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGAGSGGENPYPDPVDLIDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGSGLASLGIVSGLPVDGGDGKYKMALGADTVDFSIISGGGSKTLVGPDIQETQSRSQSPLLGSDLGKDRPQKQKAKESSNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKAESEGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTVSVGKPSSHSQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYTGQSGQSNSQSKNSSQSMGKAGSSPITKHGLSSGVSNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKLSSPMKPMPGTPPSSKAKSPIGSGGQHLSGSGSNSTTKSSSGLVSSGSLTQKPNSSSSSSSSSSSSSSSSSSSSFSGGVSQNLHSNSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGGGGGSTGVPSHGMSSKHGMVVGEFPPKREKSEKDKSKGPGSGGSSDPSKKGGGDSKGSVSTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGDGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGNRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYSMKSESWSKSPISVDPTMVMSGGSMLSSDRGVRPTPSFLMGDDDLMDMSLTL
Length1570
PositionMiddle
OrganismXenopus laevis (African clawed frog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Xenopus.
Aromaticity0.04
Grand average of hydropathy-0.609
Instability index53.44
Isoelectric point8.91
Molecular weight165674.43
Publications
PubMed=27762356

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11094
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     973.21|     149|     149|    1008|    1156|       1
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  522-  629 (74.57/12.13)	............................................................V..KKNLP.PASSpgyGMT.........SGSTAlSGIT......TPTSSYTSGQ.IS............................SLFNMGI......KERHDTTSHG.......................................ddfnkvtqnpiltsllqiT....S..NTG........G...TLG..SSPT............Q....PQ..HT..........PPPVssPASNTKNHPML
  630-  773 (153.00/31.60)	MNLL....KDNPAQD....FSA.lyGGSP......LERQNSS....GSPRTELGTLATGKP..KKKRPrTGAE...KMK.........NQTED.DFQR......ELFSMDVDSQ..N............................TIFDVGM......AG........................DALDTP.HITPA....PSqcgTP..................P....T..VYQQSIP...HA...QSNmqRMLR............I....PStdAI..........IPDV..TDILSDIAEEA
  774-  948 (114.47/22.04)	SKLS....GPGEDC......PN...LGTP......VRDSSSS....GHSQSTLFDTDV..F..QV....DGGA................GSGG.ENPYpdpvdlIDSHGSPNSDSPNtffnsvdfnpdllnsqsqsgftddlnddSSQS.GDndfkdfAGSG.LASLGIVS..G...lpvdggdGKYKMALGADTV....DF...S...................I....I..SGGGSKTlvgPDiqeTQS..RSQS............P........LL..........GSDL.............
  949- 1061 (169.45/35.68)	...G....KDRPQKQ...............................KAKESSNGGGAGG...........GLS...GMQ..................S......AGMEGKSMKRSRT............................PS.SDGK......SKDKP......PK..R......kkaeSEGKSPSHITNR....PF...TP..................P....T..STGGSKS...PG...TSG..RSQT............P....PG..MA..........TPPI..PKITIQIPKGT
 1062- 1222 (222.85/48.94)	VSVG....KPSSHSQ....YSS...SGSS......SSSSSKS....HHGHSSLSSSASGKI..KSNKS.DGSS...GMK.........IGSSG.GGMY......TGQSGQSNSQSKN............................SSQSMGK......AGSSPITKHGLSS..GvsnssgsktkPQGK.PSVLMNP....SL...SK..................P....N.iSPSHSRP...SG...GSD..KLSS............PmkpmPG..............TPPS..SKAKSPIGSGG
 1241- 1411 (131.11/26.17)	VSSGsltqKPNSSSS....SSS...SSSS......SSSSSSS........SSFSGGVSQNL..HSN.S.KGKS...PSRnkkpsltavIDKLK.HGVG......TG..GPG...SED............................PMDGGGG......GGSTGVPSHGMSSkhG......................mvvgEF....P..................PkrekS..EKDKSKG...PG...SGG..SSDPskkgggdskgsvS....TG..VAkiiiskhdggSPSI.kAKVTLQKPEG.
 1412- 1554 (107.77/20.37)	...G....GDGLRSQmqknYGSpliSGSTpkhercSPSHNKSpaytPQALDSESESGSSSIaeKSYQN.SPSS...D.D.........GGGSG.NRAQ......TEYSAEKHKKHKK............................EKKRLKD......KDRDREKKKSYS............mkSESWSKSPISV...........D..................P....TmvMSGGSML...SS...DRG..VRPT............P.....................................
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.21|      31|      48|     139|     170|       2
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  139-  170 (48.34/31.64)	LKGLVNlYKVP..GDNKLETKMYLALQSLELDLT
  189-  221 (52.88/30.65)	LHGTVG.YLTPrsGGQAMSLKYYISPYDLFDDIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.81|      11|      51|     308|     318|       3
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  308-  318 (23.90/13.60)	QHC....TGIPLIDG
  357-  371 (18.92/ 9.08)	QHCyflnKDAPLPDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.73|      20|      53|     384|     436|       4
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  384-  409 (26.19/13.03)	FQHP...GRVPIILslirhQVACNTLIgS
  440-  462 (31.54/42.67)	FQHPvndSLVCVVM.....DVQNSTHV.S
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11094 with Med1 domain of Kingdom Metazoa
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