<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11087

Description Related to SRB8-DNA-directed RNA polymerase II holoenzyme and Srb10 CDK subcomplex subunit
SequenceMTSRASVGQGPREPLQRSFSSTSTFSRPSPHRTLSQQFSSSSPTRRANDGLVDLTLDGDATGRHAPRIGTSRLRLEVSTDSKSAVVDSPAPISDATSSWKPSLPLPPPPRGRPMLHFDVPSVSNLSPRPSQDGGPDEPAIKPMPLPIRPGQHAPPASAKSRPAAGVTVKKDARPKPYVLEVPPLAPQYPPNGHADFFPWTGNHAEDQFSEPVIRHGYFDKAQMTQNETGSARPSIFPALKHKSGLQTLSSIFTSVLAQRRAHGQITSASTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLSKNIPIERAVWLAKCVGANELRSFRRKGVSGTFAMGGEAKWIRDFTVCVEQFVETIAGTCGEKDFRARIDYAIRLATHFHSEHLLDRDHYMDWLVSSLENSPQAKLPLWLLITEIYWKDMLQYRKYGRRLATALMNQLAEALNHPDHDILAPLSDRLVQLLKGLMISNTESFIAPKSWLKHRDILMSRLSSETESLSPTLAAIDRRNSRLAGPGSEKDLNTRRRFIKLLDSVLSQPFVQELARQWWQIDEDKDMLVQTVLEWATSYYRPGAAKIYVATRILRTWSQFGADVTAAVLSFIDSAVCELGRNKAALYHLVSELARSDHFSTSRYLQWLIARGGLRDGADVVPDAPCCTRLLAELPTHNLSEGILELRMTLLTRAEFSVDQEGEQIREYMAIINLDLPGMQTHVDQDLDAIDIAQSQQRIPVIASASRTNKSELGLWLRQKVRIQMIQPTIPPLDDWDDSPMKRGTSAITASEFNTVRQYLELIDDYSMLADVMMIVESSNDAEVLASCADTLNLHIETFAAIGALRGLFDTLMSRLRALSEETDSIPRGFLVSLSDLAARLPEQEITAQQLAQELLRSDRKTAADACSPVSDHMAIVETAEADFTDEIEKVLASGNSMDRGTLDRLFQRIILRSEDSWEKSPEQQRSCGLLLTRLRTFDSRHFDVLMAAWLARLLQANARPSLVDVLSPLISFGCLALRDAVLSYTSLASPTDPPSIALEMLALLTGPCHMSDIMTKQEEYRLRIKQAHMQKDHPRETLLIIRKALEHCPSDKNSAGNQQATSLEALLDSALMRELLQILVLPDSDAFTQDLVRPLLQGAMPKPKDIINSAVDDLLIPGSGPETITTEVLLNSANDLSLPFCQVKLASMLVREDNEVQDGEAARSRRLDAFDNAIKSAVNSGNTAWASIIPLLDSSVAQHLRHRAEQQFLALFPSPKTMAIENSNVKDRVLQAQNVLRIINTTSSSGPVSASSPSYPGLGPDIVAACNGLWLLLSNSYSQDTKDCVITDWLPLLISFVISHASAFDTTKSGHESRARTILSLVAIYLQLQVLDISTETANNLVEQTFDLVLHLVDTLPEDMRQQCIRSLRDAVSSPGVSYLLSYFPNPTEWLRMVQKERHPAGSGTADSRSVEKEKLTSFTLRRWENLGEPTPNVGENDTSLSLTLFGARRG
Length1498
PositionKinase
OrganismPhialocephala subalpina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala> Phialocephala fortinii species complex.
Aromaticity0.06
Grand average of hydropathy-0.268
Instability index51.30
Isoelectric point6.23
Molecular weight166232.37
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11087
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     257.12|      87|     124|     965|    1086|       1
---------------------------------------------------------------------------
  965- 1058 (133.31/122.57)	EKSPEQQRSCG.LLLTRLRT.FDSrhfdVLMAAWLARLLQANARPSLVDVLSPLISfGCLAL.RDAVLS.YTSLASP.TDPPSIALEMlaLLTGPCHMS
 1093- 1184 (123.81/58.37)	EHCPSDKNSAGnQQATSLEAlLDS....ALMRELLQILVLPDSDAFTQDLVRPLLQ.GAMPKpKDIINSaVDDLLIPgSGPETITTEV..LLNSANDLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     328.25|      89|     239|     342|     430|       2
---------------------------------------------------------------------------
  342-  430 (156.69/86.96)	SFRR....................................KG..VSGTF.AMGGEAKWI..R...DFTV...............CVEQFVETIAGTCGEKDFRARIDYAI.RLATHFHSEHL...LDR.....DHYMDWLVS..S.LENS....PQAKLPLWLL
  441-  582 (62.11/30.20)	QYRKygrrlatalmnqlaealnhpdhdilaplsdrlvqllKGlmISNTE.SFIAPKSWLkhR...DILMsrlsseteslsptlaAIDRRNSRLAGPGSEKDLNTRRRF.I.KLLDSVLSQPFvqeLARqwwqiDEDKDMLVQ..TvLEWA..............
  584-  677 (109.44/58.61)	SYYR....................................PG..AAKIYvATRILRTWS..QfgaDVTA...............AVLSFIDSAVCELGRN..KAALYHLVsELA...RSDH....FST.....SRYLQWLIArgG.LRDGadvvPDAPCCTRLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.04|      14|     129|       1|      14|       3
---------------------------------------------------------------------------
    1-   14 (26.74/13.73)	MTSRASVGQGPREP
  125-  138 (28.29/14.95)	LSPRPSQDGGPDEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.82|      32|     165|      37|      68|       5
---------------------------------------------------------------------------
   37-   68 (55.88/34.64)	QFSSSSPTRRANDGLVD.LTLDGDATGRHAPRI
  207-  235 (46.17/27.22)	QF..SEPVIR..HGYFDkAQMTQNETGSARPSI
  251-  277 (45.77/26.91)	IFTSVLAQRRAH.G.....QITSASTFKPPPRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.12|      55|      92|     804|     868|       6
---------------------------------------------------------------------------
  804-  868 (80.27/75.52)	QYLeL.......IDDYSMLADVMMIVESsndaevlaSCADTLNlHIETFAAIG.AL.RGLFDTLMSRLRALSEE
  899-  962 (79.84/51.27)	QEL.LrsdrktaADACSPVSDHMAIVET........AEADFTD.EIEKVLASGnSMdRGTLDRLFQRIILRSED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11087 with Med12 domain of Kingdom Fungi
Unable to open file!