<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11086

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMESISNEFPISLRSWPTSGHDPSALPTLIQRINFERGGFLNITEESLRQEIAEEEANGMDNDESSSSDEEEEPDKLKELMMAREELLREIEQAHQSALYALDFISLLLTKDVAVDISPLLTDLVGPKTLGADKVAASKLTEAQKLDDKQIAKGWKAQSLNKAIDSIQASAERLEKEIEHETKYWEQVLAVSDNGWAVCRLPNEKHILGVRYGFSEASSAFKTRSLAVLQRNPDGGISLDQGMSETAPKTLRARIQVNGKDTGITPVPNPAPKDAPIETLIHQARNTIFAEELWQELNREARSFAPVQDNDDCLVCPLTANKTMILELVTLGEPQPPTSSADNDIAEAIYLALHLLLSYSHRGNYRRRTQARKPISPSSMVEPAQTVTLVRGILTRLTYQESIKQLYSLLDPLCLVLNKASIPASYTRVPTTSTPPSHLSNAEKTIMTLMERLEARFALSITSSTTLNIQLRTFLSPLCSAFFVSLPNPTDPVVVTAPPFNEGYSSFEALRDYVLQATACALAASLTPSLVQLPPPPPVNDGEDKMALDSANNNEKETESQKVKEDKKWIQTGQFTLLSNVENQKQLSISVHAERSRDPKVRKPGVSLQLVWDGPRSQIPEDDDEAAGKGRSSSLSLGGEGLVRMGDSEAGKRMMEKSGKRGEKAYVWVAWENEKQNAWGEDEGEVVNSFEDVVKDVEKSS
Length700
PositionHead
OrganismPhialocephala subalpina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala> Phialocephala fortinii species complex.
Aromaticity0.05
Grand average of hydropathy-0.461
Instability index50.53
Isoelectric point4.98
Molecular weight77334.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11086
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.27|      17|      99|     421|     442|       1
---------------------------------------------------------------------------
    9-   25 (33.48/13.72)	PISLRSWPTSGHDPSAL
  422-  438 (32.78/19.44)	PASYTRVPTTSTPPSHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.58|      22|     229|     257|     311|       2
---------------------------------------------------------------------------
  257-  283 (34.34/63.90)	NGKdtgitPVPNPAPKDAPIETLIHQA
  330-  351 (38.24/ 8.78)	LGE.....PQPPTSSADNDIAEAIYLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.78|      74|     417|      85|     172|       3
---------------------------------------------------------------------------
   85-  172 (113.84/102.06)	ELLRE.IEQAHQSALyaldfisllltkdvAVDISPLLTDLVGPKTL..GADKVA......ASKLTEAQKL..DDKQIAKGW...KAQSLNKAIDSIQASAER
  507-  594 (103.94/69.28)	EALRDyVLQATACAL..............AASLTPSLVQLPPPPPVndGEDKMAldsannNEKETESQKVkeDKKWIQTGQftlLSNVENQKQLSISVHAER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.40|      10|      63|     404|     413|       4
---------------------------------------------------------------------------
  404-  413 (20.19/13.21)	QLYSLLDPLC
  469-  478 (20.21/13.23)	QLRTFLSPLC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11086 with Med17 domain of Kingdom Fungi
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