Description | Probable component of RNA polymerase II holoenzyme |
Sequence | MADRLTQLQDAADQLAQQFVASLYYVHKHHDYALLSPTDRLVTKNGGNTAQADDDIDPKPADVFKAGQRELAQDLILKEQEIEYLISQLPGLENSEKDQEQLIKQLEEELKAAEVERKEAVKEKEAVLAKLESVIRSVKRP |
Length | 141 |
Position | Middle |
Organism | Phialocephala subalpina |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala> Phialocephala fortinii species complex. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.668 |
Instability index | 44.84 |
Isoelectric point | 4.85 |
Molecular weight | 15951.75 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP11084 No repeats found |
MoRF Sequence | Start | Stop |
1) RLVTKNGG 2) TAQADDDIDPKPADVFKAGQRELAQDLILKEQEIEYLISQLPGLENSEKDQEQLIKQLEEELKAAEVERK | 40 49 | 47 118 |
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