<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11082

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDMDDLFGDGGGLSLHPSRPPSKEIYQRLDELRGTNCCQGIAWSKWGSIASITPNGTALELRNLRCDPENGSWALSEPTVTPSFSTAMEGGPLKHLSWSPTGSDLAAVDAAGRVTILSVFSSLNKPTLSRVGGDPSDDLHAVVGSFWLNMATFPPNRPTLLNGPAVKNSAKDEPEYRYEASQAPTLGPSHPNHNKSAFICLTTNGVLRLLFSQPNNKWYEVHNELESIVSSDDLITHASICPDKTGTLLIAFATTSKQLYTVRALIDWNQPKVDKANPAMLPVQPHIKTRHMAVTSWLHDGPSTPLNASHMESSMTQLSRLEFLPPCGDASGKLAPPTIVTFRSHLPTSPSHYNQEVYTTIDRWEVRDKLQSIHPAFEQLSSRRNSVGSQPGPIMFLKKRESFTVNKIAIGMEPMNHGKVLFFAYSDGSVEYRDRMDMSETFNDGNLERVWHLAQIGFTYPEDEPCLQVAFSPSSCSLVQLKNDGKVQWQQMDYRLGDLGTSMADPMYGATVAALSLSCATAVMRQLNYDDILGTAKKHATPQFIYDLLSDIARIFKLQTDYSEEAHHDMLVRNTTIQLCLCIQQSLGFKGEFNPRTFSGKFSWLVLQLRNIVVCVTMAANLNLPAPPNTPDKLSPLEDPEVINSLTGSVRWILDLMAWLIDTLTSLRSTVPPIVDLTDASKLSLPDLLAHLHSTNTVALHMLLSSSVRGFLTAICRRLQHLDYIARRAIMHTPPNASANNAQNPGQSPHPHGNLTPALRQAYTHIATLTSNTIVRVKTIETLLSSLSSLIKTAYSIPSPSSSSNQPALSGLTNEKARNNLEIKMLFGGSFPDVFKSVIVELFRKEGLLAAVEEEIDPTQLFFADFTMLEVDEDPATVRKRKNLGKTMDCFRKTWLTNPPKRDSSSHELQNGNGEGDLNGSPEAGTIGANGNAQSRHGARWRRCARCAAVMEDSTFSRQSLQWLSMQQRRCFCSGYWDTLPPGHTVA
Length992
PositionTail
OrganismPhialocephala subalpina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala> Phialocephala fortinii species complex.
Aromaticity0.07
Grand average of hydropathy-0.297
Instability index45.40
Isoelectric point6.45
Molecular weight109539.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11082
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.62|      55|      56|     607|     662|       1
---------------------------------------------------------------------------
  607-  661 (95.55/58.16)	FSWLVLQLRNI......VVCVTMAANLNLPAPPNTP...DKLSP.LEDPEV.IN...SLTGSVRWILDL
  662-  719 (65.42/40.54)	MAWLIDTLTSLrstvppIVDLTDASKLSLP.........DLLAH.LHSTNT.VAlhmLLSSSVRGFLTA
  729-  775 (47.64/26.05)	Y....IARRAI......MHTPPNASANNAQNPGQSPhphGNLTPaLRQAYThIA...TLT.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     107.65|      19|      55|      46|      64|       2
---------------------------------------------------------------------------
   46-   64 (34.67/18.87)	IAWSKWG.S.IASITPN.G..TAL
   73-   93 (22.13/ 9.20)	PENGSWAlS.EPTVTPSfS..TAM
  101-  122 (19.24/ 6.96)	LSWSPTG.SdLAAVDAA.GrvTIL
  147-  165 (31.62/16.51)	VVGSFWL.N.MATFPPN.R..PTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.79|      16|      55|     432|     452|       3
---------------------------------------------------------------------------
  432-  452 (20.78/23.78)	DGSVEYRdRMDmsetFNDGNL
  489-  504 (32.01/17.75)	DGKVQWQ.QMD....YRLGDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.39|      12|     144|     221|     233|       4
---------------------------------------------------------------------------
  221-  233 (18.61/19.65)	NKWyEVHNELESI
  367-  378 (22.77/16.60)	DRW.EVRDKLQSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.40|      49|      54|     248|     301|       6
---------------------------------------------------------------------------
  248-  301 (73.26/52.60)	DKTGTLLIAFATTSKQLYTVRalIDWNQPKVDkANPAMLPvqPHIKT.RHMAVTS
  305-  354 (84.13/45.70)	DGPSTPLNASHMESSMTQLSR..LEFLPPCGD.ASGKLAP..PTIVTfRSHLPTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11082 with Med16 domain of Kingdom Fungi
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