<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11076

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGEYLTNVLSSNDFASIKYEYFEPHNLSSWAARRQLQRAEAAWRQEGRLVLCDPYRDGIWVFERFSNTTSDYPIKEGESLSPSVVDVHGVGLVQRDQGIYEPASLARSKSAIPNNINTPTSSASPSSSLDNALRNTQALNARSAQTNVLLNVGQEPPTPSPGVKSDQSPSQKDIHEYFISAVLGSIVYLLCRDHGLVPLNSRTLILTASKTLPQSQLRIGNTQICNAIELATLDISLTSLGSLVVKAITDPAPGLQALIGTSSLLNWTDMVTPGTALWLAPSGNAARFHSLPDEARFPSTSSIARLQASPGRQRSTGFNSLSVKSWQSKCLEWLSVKGLDPVTLETGGWVFVQIFGGQSPYSSSDYQSIPMLEDLTIVPWPALLCFHTSGSGNQDYQSSRSTDTASRDPLSFAEDWFRGRDERASISLKRQKERQVAEALSKEQAAVDARAMQSHTYSPMALRRGSNAGAMYPTPPDAPHHLIGATPTFDGNGSTPGNQNLHAQPESTAVGLPATSVGDAVDIGIWSSGKKEQTTSSTHYNEHETENDNLFGDLGGDLFGTDITDADFSFFDGPDALDFDQKHASPTPALLPMSEDNTISNVRAVEDSSNANALQEYDLSMPEPTLVERSNAPHQFDSTMERVDVSIVQPSPEHTSIKTPDEPPTSSTAVAPFDKEAVFERLVKANADSTHLNQSRRASQFNTIDFETSLQAVNKKYSVHGPFNFKVQKSRPREDFSRLPQTEYLNRRRKAQDHGAEMSHIARILMEKDPFDQQNDNEPMDYLLDTTFASPISEQDDSSHTTDNPALPQKLGTKRKWEEVDGDDMTSSFDALAMDLERPVSTPQSLNGSQLPLLDADPADWSLTTYFTTAEPDVQSTALSDHERIATAQILADQAVSGTLKFPGIPRCELAYHKASSTRKLIQRLVKATKTCLKEISPCTMRAFIDIQGIPILSQGLRLASRPMPNPRGPSGIDSRPNSPFTIPPPQLEIRRSDSKLSILPAAISFWENLGLGPAKGAKDINAVCVYPNFDGVYANANTFLDQMRSIYESSRFGNHDRIQSKDIVNGLMPFAVDSQPQNRVHQLTVLKDTTGRLSKVLASLNLEEMNLVVYFAYPAGNNALLVQICSAFQHLFNMYRKSLSEKKINATNEIVLQLIPLDFMSSLTSIVVPVPDDYFRLAMEVYDRCIDFTSSSSSPAIMLEQPLPKNIDFKLNAVPSASVLQENTCLHVAYAQSIDDRWITAVWTDNRGTQQMTASYCLGRKNEPISTAFTVVANEIWETTLAFVSNKKIHWRIMIARVGVMDPSEIDFWTGLAATESDAQISLTLITVQTDPSLRLLPVPVTLGPSGNSTYSGITPVSTPQASQTSILSPENATTPVRENNSSATAVDGPLEPDSDARLIDYTDQSWGVVLSHRLNNSNSLMDQNLALISGYLVKRGGSNSDDPPVVMEVNIVYSEVLGNPRTFHESLLREILGYYRGLGTLARVRGMVDAVRDVRPWHIAAAEKAVKALYMLM
Length1517
PositionKinase
OrganismPhialocephala subalpina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala> Phialocephala fortinii species complex.
Aromaticity0.07
Grand average of hydropathy-0.357
Instability index47.58
Isoelectric point5.21
Molecular weight166574.78
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11076
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     505.33|     162|     216|     251|     430|       1
---------------------------------------------------------------------------
  251-  430 (248.61/203.29)	TDP.APglQALIGTSSLLNwTDMVTPGT.ALWLAPSGNAArfhSLPDearfPSTSSIARLQA.SPGRQRSTgFNSLSVKSWQSKCLEWLSVKGLDPVTLETGGWVFvQIFGG......QSPYSSSDYQSIPMLEDLTIVPWPALlcfHTSGSGN..QDYQSSRSTDT.ASRdplSFAEDWFRGRDERASISL
  476-  649 (256.72/158.00)	TPPdAP..HHLIGATPTFD.GNGSTPGNqNLHAQPESTAV...GLPA....TSVGDAVDIGIwSSGKKEQT.TSSTHYNEHETENDNLFGDLGGDLFGTDITDADF.SFFDGpdaldfDQKHASPTPALLPMSEDNTISNVRAV...EDSSNANalQEYDLSMPEPTlVER...SNAPHQFDSTMERVDVSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.61|      27|      30|     884|     913|       2
---------------------------------------------------------------------------
  885-  912 (39.52/24.98)	ERIATA.QILAD..QAVSGTLKFpGIPRCEL
  916-  943 (33.65/12.89)	KASSTR.KLIQRlvKATKTCLK..EISPCTM
 1266- 1286 (21.43/ 7.00)	EPISTAfTVVAN..EIWETTLAF........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.91|      10|      14|     978|     987|       3
---------------------------------------------------------------------------
  978-  987 (20.80/ 9.52)	RPNSPFTIPP
  994- 1003 (17.11/ 6.59)	RSDSKLSILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.86|      14|     375|     959|     974|       4
---------------------------------------------------------------------------
  959-  974 (25.27/20.02)	LRLAsrPMPNPRGPSG
 1337- 1350 (27.59/14.94)	LRLL..PVPVTLGPSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.46|      22|      33|     805|     826|       7
---------------------------------------------------------------------------
  805-  826 (40.32/19.90)	DNP.ALPQKL.GTKRKWEEVDGDD
  839-  862 (30.15/13.18)	ERPvSTPQSLnGSQLPLLDADPAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.91|      30|      32|     693|     723|       9
---------------------------------------------------------------------------
  693-  723 (45.35/34.90)	HLNQSRRASQFNTIDfETSLQAVNKKYSVHG
  728-  757 (51.56/34.44)	KVQKSRPREDFSRLP.QTEYLNRRRKAQDHG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11076 with Med13 domain of Kingdom Fungi
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