<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11074

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDQGSRNGSHTNHDRDQRHNGVNGGFYTSEKGQEKGKGRAEPQQNMTPISPTIPNGMNGTFSDHAQNGNGAGNGLAHGMPNRIDQLPPEILHITDGYMPLSLLLSRLAQKSYSGLLATVNDMAQMPSPPPLLNGNASHTSSADDNSPENQAKKKRLLDFVTPTHEAWLKALVITGWSRKAEEVSRAIDIKAHEDREKMHYINAIDLLAGEKRKLILARMPNPDLKTAVPVLTTGKAHWMPDLGYIPPAPLTAKEVLQSLEKLNTLLSIRLNLNDFEAIPPQFKEYTIKSGRATFRVEGEFELDLTIADEDPKSQFWFIDFRFLFTPSAPTLSLRVRNFIENKVNEISLKDGLSGCYKYLHETVLTYKISECKRQAIDLARAKWTDTLRVDGLNRALSVQYWLNRYNGFGSKSWVIIGVHSGKPDDDDPDSSSTSRLFLRWFRDHKEIKDGNIPFDTVNLSIESLLKILTAKHISHIFTAIFDKLILHPIYANKELSFSLTTSANDPSKPELKVQLTNEREICVKIDPISGRFVFSPTNRMIGFYENSLNAPSTDPKDPNRKKIEDPVDKAVRILEFLRYKLLEDDIYSRGMTFGWPKLRERPGIKPNVLSEKVPKNTQSQIWLRRPGWAEDWYLLTCLSTSGARWFLIKLVKRSTPLDPNPNAIGIAAFEKVPINVVWPTINYSFLSALNVYTTAFLSQYANCKYLYDRRVGYQPREGKPSKSLSIPYVCVRLTDLLPQQTRRPWARDYVKLTFQGVEVHATTPDDLAAAAQSLVAATQSSNTSLIQRPSNIKENAVVITEARMTIPLPKAIANLDRKVDPDIAFNPATGTFAFRLRSAVGEPVIPEMKERIVSIERLVQFVQVLQKHEKTLHCETVSLGKIVFLYSHGSPGDSNGEYMATQLPQYRATVDFSTAEKKMKLILEKGNPHIRIADFLGKVLNTTEGLNGVATILALTLPVLKGLNAIENAWDEDALYDRGEAFVSVRAADWYIIRYNLKHTGPNPDSAPVLQKVLFEVRLRERRGDPWWCIQRTNNNPRPKETDNLDDAFKPLWTSNGANWRGMRKSGVAQGSGAEELLVKMDEVVRNFALSDAIIRVREAAGNPTPAPAARQAPTQAPPSRQQQQQQQLQQQRQQPTPNQSQSQSQGRGQQVKRQVEFVEID
Length1162
PositionTail
OrganismPhialocephala subalpina
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Mollisiaceae> Phialocephala> Phialocephala fortinii species complex.
Aromaticity0.08
Grand average of hydropathy-0.480
Instability index40.36
Isoelectric point9.13
Molecular weight130752.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11074
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.89|      17|      97|     122|     138|       1
---------------------------------------------------------------------------
  123-  139 (31.61/17.46)	AQMPSPP.....PLLNGNASHT
  217-  238 (26.28/13.12)	ARMPNPDlktavPVLTTGKAHW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.31|      42|      97|     483|     524|       2
---------------------------------------------------------------------------
  483-  524 (67.19/49.32)	KLILHPIYANKELSF...SLTTSANDPS.KPEL...KVQLTNEREICVK
  531-  572 (58.08/41.40)	RFVFSP..TNRMIGFyenSLNAPSTDPK.DPNR...K.KIEDPVDKAVR
  580-  624 (60.04/43.10)	KLLEDDIY.SRGMTF...GWPKLRERPGiKPNVlseKVPKNTQSQIWLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.94|      61|      96|     256|     351|       4
---------------------------------------------------------------------------
  241-  307 (91.13/65.15)	DLGYI..PPAP................LTAKEVLQSLEKL..NTLLSIRLNLNDFEAIPPQFKEYTiksgrATFRVEGeFELDLTIA
  319-  399 (83.81/99.34)	DFRFLftPSAPtlslrvrnfienkvneISLKDGLSGCYKYlhETVLTYKISECKRQAIDLARAKWT.....DTLRVDG.LNRALSVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.04|      11|     120|     625|     636|       5
---------------------------------------------------------------------------
  625-  636 (20.66/14.68)	RPgWAEDWYLLT
  743-  753 (23.37/11.61)	RP.WARDYVKLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.29|      25|     260|     818|     843|       7
---------------------------------------------------------------------------
  818-  843 (39.69/30.08)	KVDpDIAFNPATGTFAFRLRSAVGEP
 1080- 1104 (42.61/26.81)	KMD.EVVRNFALSDAIIRVREAAGNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.43|      12|     705|     199|     216|       8
---------------------------------------------------------------------------
  186-  198 (17.88/19.72)	AIDIKAHEDReK..M
  203-  216 (15.55/10.73)	AIDLLAGEKR.KliL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.66|      10|     338|     416|     425|       9
---------------------------------------------------------------------------
  416-  425 (19.76/12.38)	IGVHSGKPDD
  757-  766 (18.90/11.50)	VEVHATTPDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.72|      34|      34|      20|      53|      12
---------------------------------------------------------------------------
   20-   53 (63.06/35.05)	NGVNGGFYT.SEKGQEKGKGRAEPQQN.MTPISPTI
   55-   90 (55.66/30.14)	NGMNGTFSDhAQNGNGAGNGLAHGMPNrIDQLPPEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11074 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRVREAAGNPTPAPAARQAPTQAPPSRQQQQQQQLQQQRQQPTPNQSQSQSQGRGQQVKRQVEF
2) MAQMPSPPPLLNGNASHTSSADDNSPENQAKKKRL
3) MDQGSRNGSHTNHDRDQRHNGVNGGFYTSEKGQEKGKGRAEPQQNMTPISPTIPNGMNGTFSDHAQNGNGAGNGLAHGMPNRIDQLPPEI
1095
122
1
1158
156
90










Molecular Recognition Features






MoRF SequenceStartStop




1) EFVEID
2) RGQQV
1157
1148
1162
1152