<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11069

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPAANEYPQDSVLPQSHYSWGTQNAISWSKHGFVTYAMPPATSGFNLYMTYLENVDGKDWQLARPQGLTIKPLEDSGVPELSMVQWSNLLTDLAVFDEQGNFYILLAGVGLLSSKGKGNGSLNGNGTSIGASNGHNNGSSNGNGHISGNSNGTAVNGSQNGASKPNPDDLEGPSYELTSYNHTEMIFRDISPTNGPPHSRCVAFKWLGIEKPQIINKAAELALDGRNYSYGVHQHQIPKLAHPIATKQACVALRQNGIFNLYYQGEHKVEYHKLSANLAADGSEGYIYFSHASIGFSADRKIIVVAYEAGSKMVYTYSISVDWGFLVDSAVKQKTDPHYHTPKEGQKLPRMTAQLLHQMAPVPNATGELSAQLMKPSIEVSRLKLIDVVSPYYNVGSDLEILLSYDVISGNAYSSTIFRYHLKDCADSMEDVFANIAGDDPVEKGKVYSLVIQDKMTVGKRLQQINTFVADSLILIIYEDGTIDAVDRSTWAVMGATETPVKDEDMDIKGLSYPQQLKTILDCGFRFPRFREDSAVSGPLMVSISPNMTCMAVQRFGGDTSLELKVMNHPHEAHDTHLTAIGVAYSHAHACYANTSSDDIIVLIREELERLSDPTLSNKLVEQLIIESHRAINFQLNSFSKESVDKLLSNPPMQKLLSLQLAVSEHHTLNRAIRDLAWVVLNLRSTSFGIMFSLSSIYRQISKKKPVEDSLEDSISRAECIILLVGNVKWLIDLIVYLNQELLQLALTRSRPEGSLINIHNSVALPIIMSKVPRLFLMYALSSIGKTHEILKKLQKDLSESNKLFTPMKEALNRFFGACNSLPLNLSIFESFLREVEILVSKEVATRAQLDSSIPLKLEQHLFCLGVIPDGIRNIANMTIERHAASINRDMKLSELYFYDSSWIDVGIATREFPKDERVKEVFKPTQIRLQYSPHESVDALRKVIISASSPITSGGVSVMGRGYDSSNKVRKCTRCRSVSLVADPLVFDAPSTIGLWTMVFQRTCICGSTWVNCS
Length1015
PositionTail
Organism[Candida] intermedia
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.165
Instability index37.16
Isoelectric point6.27
Molecular weight112409.90
Publications

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process

Interaction

Binary Interactions

Repeat regions

Repeats

>MDP11069
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.50|      22|      32|     108|     136|       2
---------------------------------------------------------------------------
  108-  132 (31.58/32.77)	GVGLLSskGKGNGSlNGNGTSIGAS
  142-  163 (41.92/19.58)	GNGHIS..GNSNGT.AVNGSQNGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.22|      46|      51|     615|     664|       3
---------------------------------------------------------------------------
  615-  664 (61.95/59.63)	TLsNKLVEQL..IIESHRAINFQLnSFSKESVDKLLS.NPPMQKllSLQLAVS
  668-  716 (66.27/46.55)	TL.NRAIRDLawVVLNLRSTSFGI.MFSLSSIYRQISkKKPVED..SLEDSIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.11|      13|      32|     286|     298|       4
---------------------------------------------------------------------------
  286-  298 (25.20/15.37)	YIYFSHASIGF...SA
  315-  330 (20.91/11.48)	YTYSISVDWGFlvdSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.77|      25|      32|     343|     369|       6
---------------------------------------------------------------------------
  343-  369 (38.76/32.31)	KEGQKLPRMtaQLLHQMAPVPNATGEL
  375-  399 (41.01/27.42)	KPSIEVSRL..KLIDVVSPYYNVGSDL
---------------------------------------------------------------------------




Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP11069 with Med16 domain of Kingdom Fungi

Intrinsically Disordered Regions

IDR SequenceStartStop
1) LNGNGTSIGASNGHNNGSSNGNGHISGNSNGTAVNGSQNGASKPNPDDLEGPSY
122
175

Molecular Recognition Features

MoRF SequenceStartStop
NANANA