<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11068

Description CIC11C00000002137
SequenceMNGMQNALMGGTWHATVGIADRQKVVQVLASSLKGIRNTDDLRAATMALEFEKYTFMKAASKEEYMRLIKHKVTQLNAGKRANPDGGPMGQNDMAGQGMNPGMNQGMNQNMNQGMSQNMNQGMNQNMNQNMNQGINPGMNQNMNQNMNQNMNAMGNQNMNSMGNQNMSGMNQNMANLANLNMNNNFMARQQQQQQQQQQQQQMMRNNMMSQQGQVKPAQQKLVNPLQPQQPLQMQPSLQPTQQQIQQISNMIRTVTIPSALLAKIPNLPPNANTWAQIYDCMNNNVIPKSALPLVKEIHNSHFQLALRQHQQQKLAQFQRMNGNTQGNDAAMRAGQNAQFNMTGNNNNNNVNMNSNMNAGMNSNMGSNMNTNMNNMGNMSNMNMNHMNMNNMNNMNNMNNINSNMNNMGNINSSMNNMGNMNNMNRQLQGNNVNMDQLLMQQQKQQSVFRGNNKPQNIPQAQNAMAMPMNASQQQPQQPQLQISNQPVGMAQTRQQQNDLQNMQITAQDLAKYSGDAMTFLQRLQQSGTMPGNFDRAQKEKFIRRYVLHQKQKNQKEQGQAQNQNMAPNSFQSIQQPEQQQSLTQQQPPSQSMLQPNMSGQPPQLLPMMGQMPQPNQAGMNQQHFSPMVGQKAVPVQQPANNINANQMRQNPPTAIIPALTDEMKAKLRALFEEVARNAVPLKDMTLLLSEKDKAQVRETMTKITQQYANVDSILNYFYQLTRSLEATKRLIQLKRMTKNILENLQRGVFLATPELVEKMRAQYQKYFDYVKEQLTLKRQQQSQQQPVAPQQGRNVPGAQQFNVNQQFTPLNMQQQPAQQQNFPVQAGGPQMGMQSGIPGQQQQFVRNATNSQMQQDWQKPNNNLAPQRVGGAMSSSPIMPNAVSPSVAQTAAKKGPVKAPSVTATAARRKSAKSGSTPSASAPTPATLANAIKTPNSISTPHIPQSQSNKGTPLGNSPHLDNKNPVVEVPLLGEVFGVSSADSKVIKRRELSTSNPEKFFFAALSNLLDLPDGENGQNGSKPAVDGSKALINSPLSPKVPGEWSSDVKPYAITSAFRQVEFIRELTSSDILDECRQMVEQEAIVKKENSVKREREEDNDLELLFGEKKVKTEDVEFERYLYEPVEFEEWKGWINGLQQTNT
Length1142
PositionTail
Organism[Candida] intermedia
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.04
Grand average of hydropathy-0.875
Instability index51.22
Isoelectric point9.74
Molecular weight127809.15
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11068
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.45|      18|      18|      98|     115|       1
---------------------------------------------------------------------------
  110-  129 (34.88/ 9.00)	NMNQGMsqNMNQGMNQNMNQ
  130-  149 (32.57/ 7.81)	NMNQGInpGMNQNMNQNMNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      14|      18|     352|     368|       4
---------------------------------------------------------------------------
  153-  168 (21.52/ 7.79)	AMGNQNMNS.MGnqNMS
  355-  370 (22.40/ 7.97)	SNMNAGMNSnMG.sNMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     217.06|      30|      30|     236|     265|       6
---------------------------------------------------------------------------
  191-  214 (38.60/11.05)	.QQQQQQQQQQQQ....MMR.....NNMMSQQGQ
  215-  237 (33.96/ 8.67)	VKPAQ...QKLVN....PLQ....PQQPLQMQPS
  238-  267 (44.45/14.06)	LQPTQQQIQQISN....MIRTVTIPSALLAKIPN
  473-  499 (28.99/ 6.13)	QQQPQQPQLQISNqpvgMAQT....RQ...QQND
  548-  574 (30.93/ 7.12)	LHQKQKNQKEQGQ....AQNQNMAPN...SFQSI
  777-  803 (40.13/11.84)	LKRQQQSQQQPVA....PQQGRNVPGA...QQFN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      95.30|      19|      19|     918|     936|       7
---------------------------------------------------------------------------
  881-  897 (21.87/ 9.66)	.PNAV.SP.SVAQTA.AKKGP
  898-  917 (19.38/ 7.59)	VKAPSvTA.TAARRKSAKSGS
  918-  936 (31.99/18.06)	TPSAS.AP.TPATLANAIKTP
  937-  954 (22.07/ 9.83)	N.SIS.TPhIPQSQSNK.GTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.86|      42|      73|     955|     996|       9
---------------------------------------------------------------------------
  955-  996 (71.56/49.34)	LGNSPHLDNKNPVVEVPLLGEVFGVSSADSK..........VIKRRELSTSN
 1019- 1070 (65.30/44.34)	NGSKPAVDGSKALINSPLSPKVPGEWSSDVKpyaitsafrqVEFIRELTSSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.35|      18|      19|     406|     423|      10
---------------------------------------------------------------------------
  332-  348 (29.31/ 9.27)	MRAGQ.NAQFNMTGNNNN
  406-  423 (35.89/13.53)	NNMGNINSSMNNMGNMNN
  638-  653 (26.15/ 7.22)	QPANNINA..NQMRQNPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.52|      15|     223|      91|     106|      11
---------------------------------------------------------------------------
   78-   93 (26.24/10.57)	AGKRANPdGGPMGQND
   95-  109 (32.27/10.31)	AGQGMNP.GMNQGMNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.97|      10|      22|     727|     736|      15
---------------------------------------------------------------------------
  727-  736 (15.94/12.43)	ATKRLIQLKR
  752-  761 (17.04/13.89)	ATPELVEKMR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11068 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EIHNSHFQLALRQHQQQKLAQFQRMNGNTQGNDAAMRAGQNAQFNMTGNNNNNNVNMNSNMNAGMNSNMGSNMNTNMNNMGNMSNMNMNHMNMNNMNNMNNMNNINSNMNNMGNINSSMNNMGNMNNMNRQLQGNNVNMDQLLMQQQKQQSVFRGNNKPQNIPQAQNAMAMPMNASQQQPQQPQLQISNQPVGMAQTRQQQNDLQNMQITAQDLAKYSGDAMTFLQRLQQSGTMPGNFDRAQKEKFIRRYVLHQKQKNQKEQGQAQNQNMAPNSFQSIQQPEQQQSLTQQQPPSQSMLQPNMSGQPPQLLPMMGQMPQPNQAGMNQQHFSPMVGQKAVPVQQPANNINANQMRQNPPTAIIPAL
2) RLIKHKVTQLNAGKRANPDGGPMGQNDMAGQGMNPGMNQGMNQNMNQGMSQNMNQGMNQNMNQNMNQGINPGMNQNMNQNMNQNMNAMGNQNMNSMGNQNMSGMNQNMANLANLNMNNNFMARQQQQQQQQQQQQQMMRNNMMSQQGQVKPAQQKLVNPLQPQQPLQMQPSLQPTQQQIQQISN
3) RQQQSQQQPVAPQQGRNVPGAQQFNVNQQFTPLNMQQQPAQQQNFPVQAGGPQMGMQSGIPGQQQQFVRNATNSQMQQDWQKPNNNLAPQRVGGAMSSSPIMPNAVSPSVAQTAAKKGPVKAPSVTATAARRKSAKSGSTPSASAPTPATLANAIKTPNSISTPHIPQSQSNKGTPLGNSPHLDNKNPV
297
67
779
660
250
967










Molecular Recognition Features






MoRF SequenceStartStop




1) FIRRYVL
2) PVKAPSVTATAARRKSAK
542
897
548
914