<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11064

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGTSVSPQPITAANGINLAQISKGKLPELPHITNNIVPLSNVLRFYTQEAYKQLSRVIENLANTRTSESDIARKKKFLEVIILLRQDFIKIYTLVKWAQNAKDVSKLIDLLNWLRTQEFCFDNLGYGLNELNSFSGAKLPNSDILTSLEVLVNGRPQLPTYNYIAKPKISAEKTLEVIRDLNLTLLARMALINDMPRRFYNNYEVRDGRVIITIPNEFQVSITVANDLIIDDDKDYYKSPFFFIDFAFLFGINPDTSLITYKDAKVITTLPKASRAKLESVVNEALLKQSLTGLYDVLHKYAVSFKLYLISRQLRDLSVNSKWRNNLQYKYNSSLIIINYWCNHYLSRNWKSFIEIGIDKLYNLNFRWFMNGKYNLNHDIQDISGNSDSEDVDDLTVDFILNLIINKHSEILMAKIHSQLASMIPDDSISFVNPYQLLIKLTPRKSTFLAINPLTGFFYFMDPSPLEVLTQNRINSQPAQVKNKNFVSEQDMVNNVVKNLIQLRLDTFNLALNTKLVTSEWIANDFIKINDYETVKLFNFIIDEKATSSNKIQFYRCRNWPSSWFLINMISGLTSKVYWWVARLKSIKGEWKIQWVQKLKFGGEEDLDYEFFNNLSRSCSNMIVDHMVVEELLARRINYVKVDDSTTMDRFNLSHDLQNTSANYETVMALHNTGKLLPISVSSTTLFLIVRLTTVDNATKLILTLSGSLKNISSSDVETFSKFNVTIQPENDTFELLTSVDLSNKMSENSDNSNPVSLLNELFDNMAKVNLLIKMLYQLKKTNILVTNNSANDITFDIDPFYKPFHLRLPEGKSGLLTLTSSPEEDQNVQLLVAFINQRISESHEALVGSIKYLKEYVPIIKSVKKVKDILKLNDSDRLPNKLQRLQFDVKFQNLNLMQFIFHINYVSTSSSKKVLKDRIVFSLTYKRNAFEKNRRLLVKFSMKENLNSHNLKYKKLFESVFKAAGEVQQEKQKEYNKIVLMKLNYDFLIDNGLLEPLMAKVTECFLQFLKNEN
Length1015
PositionTail
Organism[Candida] intermedia
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.10
Grand average of hydropathy-0.207
Instability index34.09
Isoelectric point8.98
Molecular weight117267.73
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11064
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     847.73|     196|     275|     307|     505|       1
---------------------------------------------------------------------------
   97-  275 (139.56/80.63)	.......................KWAQ.N..AKDVSKLIDL............LNWLR..TQEFCFDNLgYG.LNeLNSF.....SGAKLP.NSDIltslevlvngrpqlptynyiakPKISAEKTLEVIRDLNLTL............................LARMalINDMPRRFYNNYEVrdgrVIITI.....PNefqvsitvandliidddkdyyK.......SPFFFID....FA...........FLF...GINPDT...................SLITYKD..AKVIT.TL.PKAS
  307-  505 (318.99/207.42)	KLYLISRQ..LRD.LSVNS....KWRN.NLQYKYNSSLIIINYW...CNHYLSRNWKS..FIEIGIDKL.YN.LN.FRWF.....MNGKYNLNHDI......................QDISGNSDSEDVDDLTVDFILNL......IINKH..SEILMAKIhSQLASM..IPDDSISFVNPYQL....LIKLT.....PR.....................K.......STFLAINPL..TG...........FFY...FMDPSPLEVLTQNRINSQPAQVKNkNFVSEQDmVNNVVK.NL.IQLR
  514-  731 (205.03/122.36)	NTKLVTSEwiANDfIKINDyetvKLFNfIIDEKATSSNKIQFYR...C.....RNWPSswFLINMISGL.TS.KV.YWWVarlksIKGEWKIQW.V......................QKLKFGGE.EDLD...YEFFNNLsrscsnMIVDHmvVEELLAR...RINYV..KVDDSTT.MDRFNL....SHDLQ.....NT.....................S.......ANYETVMALhnTGkllpisvssttLFL...IVRLTTVDNATK.LILTLSGSLKN...ISSSD.VETFSKfNVtIQPE
  746-  921 (184.16/108.54)	KMSENSDN..SNP.VSLLN....ELFD.NMA.KVN.LLIKMLYQlkkTNILVTNNSAN..DITFDIDPF.YKpFH.LR.L.....PEGKSGL...L......................TLTSSPEEDQNV.QLLVAFINQR......ISESH...EALVGSI.KYLKEY..VP..IIKSVKKVKD....ILKLNdsdrlPN.....................KlqrlqfdVKFQNLN.L..MQ...........FIFhinYVSTSSSKKVLKDRI................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.21|      17|      18|     923|     939|       2
---------------------------------------------------------------------------
  923-  939 (28.58/15.63)	FSLTYKRNAFE.KNRRLL
  942-  959 (25.63/13.28)	FSMKENLNSHNlKYKKLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11064 with Med14 domain of Kingdom Fungi
Unable to open file!