<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11062

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSETDKVRFHLDRNLSGVTQDPFLQDEESIPIADLIPQILHERQSFLNITEEQLQDEINQGDIDREEEDDESQLHNAKEADEDTESAYQAFQKRKFELLGNINSAMNETSLSLDFVSLLMSAVKPNVAKTTISPHLTKNVPLGSLSSDRLTMDEDSQDKAKGAKRDNPESIGLGWKYQSLTHITGLFKNAGAQLREQVHIEHRYWNMINKVLGHGEVLFKVRDPKTGARAIGVKYGYGDSGSNYYDKGLAVLRKDEQTGDVTFSPIMTGNHKISQKSNKYTRIKVLSKIDDDFMLTGQSLFDKDAIADKSEFKVINDIEKARYFLFEDDLFYHLIREAKNLINYNVSIISNRIIIEIFDQIIEIESVVYDEDNEEELNNTYQNINKESSKNNDKAQAIYIFLKLMLCCYYDYNLELKQKIPTSFTKWKQSNSHPLMLRPLIGHMRHEINVHRMNIILNNVCKALDATKLSYEIAEEKYVNLHTEKLTNPFRKAVTKPLSKFKVILQKLSTKEYLNVEVEVTSSDIFVNLVVVLTISKYNNIEDLKQNQQGSNVLLLKFTDLMDIEESLNWSILNFLQK
Length578
PositionHead
Organism[Candida] intermedia
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.506
Instability index47.22
Isoelectric point5.42
Molecular weight66561.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11062
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.98|      17|      29|      10|      38|       1
---------------------------------------------------------------------------
   10-   27 (25.60/28.45)	HLDRNLSGVTQDPfLQDE
   41-   57 (29.38/ 7.95)	HERQSFLNITEEQ.LQDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.63|      18|      29|     284|     301|       2
---------------------------------------------------------------------------
  251-  263 (17.69/ 7.81)	.VLRK.DE.Q...TGDVTF
  284-  301 (31.52/19.05)	KVLSKIDD.DFMLTGQSLF
  313-  331 (25.43/14.10)	KVINDIEKaRYFLFEDDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.50|      22|      81|      64|      86|       3
---------------------------------------------------------------------------
   64-   86 (34.74/25.97)	DREEEDDESQlHNAKEADEDT.ES
  148-  170 (34.76/21.20)	DRLTMDEDSQ.DKAKGAKRDNpES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.63|      14|      31|     175|     188|       4
---------------------------------------------------------------------------
  175-  188 (27.22/21.06)	WKY..QSLTHITGLFK
  205-  220 (22.40/16.04)	WNMinKVLGHGEVLFK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11062 with Med17 domain of Kingdom Fungi
Unable to open file!