<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11060

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVDAASALRISTHYYKIAHLLLVTFAIYTAKEPTVDQYLLELELQIRNQHPKILLTYYNKSLYHFRFDHLKEERDFVNNEQHQKDDTSNLQLHILYPQLSLKHEYTVGADQLANPSRVMKGVKKDSYSKIDLPEGQLAFASLSFLKAVKKTLVYNLSASGNMLLFGNYVVARVAETSAQYSVVQVDPVLLANGDIVVSLSQRNKLALFDSAILNLDHVFQEMASCFVIYVVPSGLRCHLYDTSSMQHSFTYTPPKSSVNLLRLLKLSTGVELKQKQQILWVKLVPNLQHLNNQTSKISHFVHEVDNKKYILWPWELCLLQFGSVEKNPIHDNSPLNVDPLSLISDFIQFSILRHENDNVERHMETLTGPGSATNHITTHPPFSVPSAFSIGMSTEGNDKHEDTHMSILETNPEVLGLFEIDHNEDLFGSENVLDVPLLGSQDTKTKEKGSELEMKEDGVEDDSDLFGSSPELDSKQAGEALMEDFDPRKSEIHNMEVDSQEALSNSEKIFEDPQGSENEALDIKSEIQPPSAFPGFINIPRDQMISGPANMTPMSYDDPGAPPAIMPTPMIPTPVIPQNVSDVQGGFGMQAIPHPHTTPKVPLHLFPQPGKPLNPFASRDSKEAIQGEDNLAYVFSPILFNPMIKSNIDTKYGKGGKFYVARESSTGPEEFKFRLRETSVSGFDSKKELSEGKFLPELLDSVSSSKDSKIDNTFFPDGTLIQKEDIHEEVVDDDVNEEDEEEDEEDEEEDEESDVDEEDVIALKTSPPLKLNTHDIFQMLNAAEILKGLNVTSSLQSNQSNNFLSPGSSIIKVQPSNKVDSPFGFSMGTLDVPTSSLSPPILNDLKQDSLLGVINRSDDLNQQTDNGGNKEPGTAESANTPLSNSSSGNGISESSNCLPLILRNINVVSIPNCFIVKKAPGVWGNVPISTGFNMDVDEEEDEFDVTDGTLSVRLMDLDECLKWLMPNLVFDLGLINFEKRLQIKFPEFFSEELADNITDGEVSSEVKDCFLATFPLSYRVKLSEFVNENEDLAKDVSEPQREIDNRLSFLDDITNNDILDEETSSKKMMKLHWDSIHPELKVNQQKFKNYCELVTSSQTNSDKKNDDGSVFSLNEVKTKVFKNGDNIINLNVTGIKFWNYFNFSPLNGPKRFQVLVISENDARNQDGNLFDSSNLDFLELLRSNYKEGHFGTIKKLNLQTSDTRPDLDGISNGLMLVDKGIGEGAYREFYKKINKKLKSLAELIKLDIINKTNRFEFDRPLLLLFVNFDSSINSVLQISKICRNFKLFLNDHQLSLVNTFTQIIPWNYIITQSDMRRRLRYLSNSKLSKISMSLYNKCPNVDNHDSRFNRDNTRKLYTNLVKEPPSTLHFKFMNKVNKEGYTSSFHDDIFLHVAYERSVDKSWVSAAWSDPLGIVTHTKSWYCLSKARTNGADAHELGSIINDIWDISNNFFKTLNDDAVQRTCGSGAKNFLVLTRISSIIPDDELVFWKKLTTKHKDISLLVLSANRLPKYIFSSEPRNVPSGTSESTTGVKNNFDETTPNFMQNLGQNRNSISSSMSGPDFFKSINGMGNVMSPSSSGAGFTLTSPMNSSALSFHSPQQFLNAPSNFLSPLDAAGTAGTGLGLNSISINEADYIIKDPCLEILGVIPKIPLPSFNSPTRLGMRIGYLIRESKTENANSEVKDLVFEVTLLSCSSYWNLDAIMKILLNQYKKLIVLNDVMGTCDREPKKTTNTTEIRSLVPWHINAVVKTIDYLVHVNVDEPT
Length1764
PositionKinase
Organism[Candida] intermedia
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.397
Instability index39.66
Isoelectric point5.03
Molecular weight197919.71
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11060
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.41|      20|      24|     479|     501|       1
---------------------------------------------------------------------------
  479-  500 (30.46/21.18)	EALMEdfDPRKSEIHNMEVDSQ
  507-  526 (33.94/13.31)	EKIFE..DPQGSENEALDIKSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.98|      19|      24|     530|     553|       2
---------------------------------------------------------------------------
  530-  553 (29.04/27.98)	PSAFPGFINIPrdqMIsgPANMTP
  559-  577 (39.94/21.67)	PGAPPAIMPTP...MI..PTPVIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.02|      21|      24|     398|     419|       4
---------------------------------------------------------------------------
  383-  412 (25.97/17.95)	SVPSAFSigmstegnDKHEDTHMS..ILETnP
  413-  436 (25.04/12.29)	EVLGLFE.......iDHNEDLFGSenVLDV.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     638.06|     237|     280|     746|     990|       5
---------------------------------------------------------------------------
  746-  904 (217.69/104.98)	............................................................................................................................DEEEDEESDVDE.EDVIALKTSPPLKLNTHDIFQMLNAAEILKGL...NVTSSLQSNQS..NNFLSPGSSiIKVQPSNKVDSPF........................................................................................................................................................................................................................................GFSMGTLDVPTSSLSPPILNDLKQDSLLGVINRSDDLNQQ.TDNGGNKEPGTAESANTP...LSNSSSGNGISESSN..CLPLILRN
  905- 1184 (328.73/174.64)	INVVSIPNCFIVKKAPGVWGnvpISTGFnMDVDE..EEDEFDVTDGTLSVRLMDLDECLKWlmpNLVFDLGLINFEKRLQIKFPEFFSeeladnitdgevssevkdcflatfplsyrvklsefvNENEDLAKDVSEpQREIDNRLSFLDDITNNDILDEETSSKKMMKLhwdSIHPELKVNQQkfKNYCELVTS.SQTNSDKKNDDGS........................................................................................................................................................................................................................................VFSLNEVKTKVFKNGDNIIN.L...NVTG.IKFWNYFNFS.PLNGPKRFQVLVISEND.....ARNQDGN.LFDSSNldFLELLRSN
 1190- 1270 (58.36/22.14)	FGTIKKLNLQTSDTRPDLDG...ISNGL.MLVDKgiGEGAYREFYKKINKKLKSLAELIKL...DIINKTNRFEFDRPLLLLFVNFDS.......................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1503- 1578 (33.27/ 7.96)	................................................................................................................................................................................................................sinsvlqiskicrnfklflndhqlslvntftqiipwnyiitqsdmrrrlrylsnsklskismslynkcpnvdnhdsrfnrdntrklytnlvkeppstlhfkfmnkvnkegytssfhddiflhvayersvdkswvsaawsdplgivthtkswyclskartngadahelgsiindiwdisnnffktlnddavqrtcgsgaknflvltrissiipddelvfwkklttkhkdisllVLSANRLPKYIFSSEPRNVPSGTSESTTGVKNNFDETTPNfMQNLGQNRNSISSSMSGPdffKSINGMGNVMSPSS...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.95|      14|      24|     111|     124|       6
---------------------------------------------------------------------------
  111-  124 (25.61/17.72)	QLANPS.RVMKGVKK
  136-  150 (19.34/11.42)	QLAFASlSFLKAVKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.68|      21|      24|     663|     686|       7
---------------------------------------------------------------------------
  663-  686 (28.61/30.06)	ESSTGpeEFKFRLREtSVS.GFDSK
  688-  709 (32.07/19.71)	ELSEG..KFLPELLD.SVSsSKDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.69|      12|      24|    1272|    1285|       8
---------------------------------------------------------------------------
 1272- 1285 (17.30/17.02)	INSVLQIskICRNF
 1297- 1308 (24.39/16.11)	VNTFTQI..IPWNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.54|      24|      25|     301|     324|       9
---------------------------------------------------------------------------
  271-  292 (30.10/18.24)	..ELKQKQQILWVKLVP..NLQHLNN
  301-  324 (45.41/31.89)	VHEVDNKKYILWPWELC..LLQFGSV
  329-  349 (21.03/10.16)	IH..DNSPLNVDPLSLIsdFIQF...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11060 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIHEEVVDDDVNEEDEEEDEEDEEEDEESDVDEEDVIALKT
2) SENVLDVPLLGSQDTKTKEKGSELEMKEDGVEDDSDLFGSSPELDSKQAGEALMEDFDPRKSEIHNMEVDSQEALSNSEKIFEDPQGSENEALDIKSEIQPPSAFPGFINIPRDQMISGPANMTPMSYDDPGAPPAIMPTPMIPTPVIPQNVSDVQGGFGMQAIPH
3) SEPRNVPSGTSESTTGVKNNFDETTPNFMQNLGQNR
4) VINRSDDLNQQTDNGGNKEPGTAESANTPLSNSSSGN
725
429
1516
853
765
594
1551
889










Molecular Recognition Features






MoRF SequenceStartStop




1) FKFRLR
671
676