<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11058

Description CIC11C00000005220
SequenceMSKQKKNSLLAGHSRAAHTTSAKDEITAMKYVMDKPILPVYPLDDKQPPKVYPDYVPWQEDDSMKDKLKNSGYLNKGYFESPLVSNEYYSARNLIQETLFSSTQNCSTILKELSQHFTKAYKTRNEVINKISYSSNAFKVPPRVTLTASKKEAWLKDLANQDVPLLAVSVKLPHGIRNKVLVDSMCNYVVPISRAIWFTKCSLYSELLLLRRKYQSKQSSIPQNGVVNFPPLDVFEGRWLQEWTQQVADYVFKFSKEMPNVGTGERKGPFQSKLNYLLSYILSLYVERLIDRVFFLSSIIKFLRDDLPFDTADLALLLDLSKAEEGEELAILSQLLKGRSVNYGQILVGMTLITMFWNDIMEEDFLCKYFSESLLLNHFLIEKIPVLTAKTSRSSLASSSLLKMLKDDLLLLISTSINKLFKHNTNVFIVPNYWVLIGDVLYQVLMKDNSLTDPIQQENLQKVLQLINYRNVSLMLNMKYLVREERKEVSPRVSARRSSYLDADYQSASSKSRYQRVEEAEHTYINRATDDNLKFVEQLDNLKLNNSLTALLKPRPSTLFDSNLWKTKLKIVVYWCVTVYRDMGSSSEKILIICNYLKRKVLQALTTRGSSHLKAEFENELLESIFSLSQEPAENICMYNLYVLINELYQLKIISISSYLRKIIACGVFYKSPQEGENITQLSSDPQISFHLSILRNLPVLNNKQCDHILRKWTVEGFNFLDHFTSGTSLLQEHFLNCLVNNTFGSKFHESLQTISSLNVGVKFLLVNWLTSQVKKTISNSPRLIHITPSTIANIYLFYSITDNLTVFFKVFVKYVLQNENKVIIFYLDTLYFISKLILHHHNLVKFIAGSSYEAVSSAYELFKLVILNYKDLLSRETDLYKFKEVWRIIDSSVEKSSKTESMQTHTTKGGLDRLLYGRETADSPVKISAHATRQNDAYSAETFKYDLESLLTLKIPDLTGEELDDCFNEIAHWGHPFKKEQFTDINLAEQAIQQVLHEWLQRVAKLTESEDLAIFKLLETLKKNFKLNGGTMFYSCVQLFVSEVLQKKQVNHELALLLAKLLTYEILLIFDLFNIFRQLHNSADWLTEIFTFGSNEVFGSLFSYQSLLLDNIQKEYIRKHYDDVVIYSLERLKKEGMHSEKGIFVRHKNSILGVVRDALIFNRKWTMHCLVGEMETKDLIELCDQLFPSELLVSNIDDISNLAKASNEFSLPIIQTILKVVTTSILDPNKVQVMASTILDNLHFLFGPQNSYFGEMFNYLDWGFKLQIFNYLEKIFLTQIQFEPVWELENAMVTEDVHYVSLRLNEDGIELIPIFKDFFKKFSVSSVDKLDTPPELFENLSNFLVKLLQLLNNQAAVELDDRTIHDTISILLRLLIIHKTSLTSAMAREDSVNFVFLKNLVALLNSSYLADGHEKLRILLYDLLLLMKSSLTQILSVASDDIMATSPQQNSLHSPLNAEAKRDNALLESSDYGSNALSTIMALPFETSGSAESNSAIALDRSELENDGDIDFVNQSGLVLQHCRRDSMTFIPYMAQDDHPSVPFSIKSLKLIEDTSTGLNDGCIDLSLFDAYTTKENPL
Length1580
PositionKinase
Organism[Candida] intermedia
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.10
Grand average of hydropathy-0.116
Instability index40.56
Isoelectric point6.07
Molecular weight181326.45
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11058
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.94|      30|      48|    1360|    1391|       1
---------------------------------------------------------------------------
 1360- 1391 (46.86/37.72)	LDDRtiHDTISILL.RLLIIHKTSLTS..AMARED
 1410- 1442 (41.07/26.12)	LADG..HEKLRILLyDLLLLMKSSLTQilSVASDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.61|      82|     354|     262|     380|       2
---------------------------------------------------------------------------
  284-  380 (115.03/178.44)	LYVerLIDRVF.........FLSSIIK...FLRDdlPFDTADLAlllDLSKAEE.GEELAILSQLLKGRSVNYGQILVGMTlITMFwndimeeDFLCKYFS.ESLLLNHFL
  641-  736 (125.58/90.58)	LYV..LINELYqlkiisissYLRKIIAcgvFYKS..PQEGENIT...QLSSDPQiSFHLSILRNLPVLNNKQCDHILRKWT.VEGF.......NFLDHFTSgTSLLQEHFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.03|      31|      54|     994|    1044|       4
---------------------------------------------------------------------------
  994- 1024 (51.63/61.08)	QQVLHEWLQRVAKLTESEDLAIFKLLETLKK
 1049- 1079 (51.40/21.89)	KQVNHELALLLAKLLTYEILLIFDLFNIFRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.28|      12|      15|     854|     865|       5
---------------------------------------------------------------------------
  854-  865 (18.56/10.05)	EAVSSAYELFKL
  872-  883 (19.72/11.19)	DLLSRETDLYKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     386.17|     110|     352|     741|     852|       6
---------------------------------------------------------------------------
  741-  852 (173.39/122.99)	NNTFGSKFhE.SLQTISSLNVGVKFL......LVNWLTSQVKKTISNSPRLIHIT.PSTI.ANIYLFYSITDNLtVFFKVFVKYV.....L..QNENKVIIFYLDTLYFISKLILHHHNLVKFIAGSS
 1096- 1207 (147.67/95.70)	NEVFGSLF...SYQSLLLDNIQKEYIrkhyddVVIYSLERLKKEGMHSEKGIFVRhKNSI.LGV.....VRDAL.IFNRKWTMHC.....LvgEMETKDLIELCDQL.FPSELLVSNIDDISNLAKAS
 1209- 1278 (65.11/37.21)	.........EfSLPIIQTI..................LKVVTTSILD.PNKVQVM.ASTIlDNLHFLFGPQNS...YFGEMFNYLdwgfkL..Q.....IFNYLEKIFL...................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11058 with Med12 domain of Kingdom Fungi
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