<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11048

Description Rna polymerase ii mediator complex component srb8
SequenceMTSRPGPTAAQRATAGNLPRPPIQGRPAVQQHFQANARPPADVIDLTADEAKQPSADAPPKKANQQDDPRWVAPDTQFAAQDGFSRPPPRGRPQISFEDVADAATSGLGRAASAALRSTAIASSGSLPFPPRPGLRVHKRQPQGARAASSAAGGVKKDVAQRNGVVEPPPDAVRVSRGKTVDFYPWAGNHPEDNLSAEVVKVGYYDDRKGQVDLNAGKSYVGPQVKNKTTLQALSSLFVQALEKRQASGRVREPSSFKPPPRITVKDTQREEWLRDLANPSLPPKRRIPHGIRGKLLLEQCLSKNIPISRAIWLAKCVGANEMRAWMRKGASSTGGMGGELKWVREWTVFVEQFVDSTISTCGQDGWRDKMDYTIRLASQLYTERLLDQDHYLDWLLTSLESTEIERLPVWFLMVQIYWQDLVTVRRRGRRLAEALLLQLGSITKGDDPDVDDPLVQRSQQLITALIQGHRNCMVIPRTWKKHKRILESMLTSSTQPALQSALRSIIRRNERLSGWSYKPTQTHQSPQKAILSALDSVALDFDLKDLATRCLAIMPDTQGLAVTVLQWACSLYREGGHRLYIAARLLRKWKFMGADIDSAVLAVLSDEQKLKGIKHRDFFRLVAELVRSKHFSVGRYLQWLIASGSLSAGGDVTKSEACNVRLIAEIPLQGLPEHVLNLRQTLLQTTLQNGAYEAVMLMDDHSGIIKQLWSIFAPETGAEIIFDIPFVDLSTSVRLEISRWLRQELLARLESSSGDDEDEMRDDYVLTATRFYAIRGVMEQLEDFAILADILNISLQSGDTMILAAIADTLNHHHRTFAAIGALRPLFNGLVEQYGKFRLEKPSERAFLLALADLCCRLQAEPNLVLQLTSDITRLEQRSAVAACSPASDNMSDFHSGKMDFDEEIDRILASGTTMDENMVARVFARVVSRIGEQTGKEDGRNSRYGQWLQRLKAFDDKTFDRHMSDTISSLILSDGQSLLHILPCAVGSGSLSLENFISFSESTIGVLKKRNLSAAANASLHVLDAILPMEGLQGFGLVQEIYRYRIEQEKLCQNSQGTALQLLRQAIELCSDSRDSNQLVQLEALLRNQRLLKVLRYHASRNAQDFCVSLGISPPSGKSDAAMSLDEKRSTLFKKMFDALMDPSSSLGLSNLDAEEQASTLVNAADDLSVPFCQLELQLLFKIQVLSDEEGEIGVADAIIQAVKEAVEADKSIWSDLLTGLDAEMTRKIREYAETHVLSAVTTLAKARSSVEDSSVSSSKEGYERMLQRYLSVLNLTAWSIEDKAQGQICTAILDRLRTLHELLSQAAQLGPAGDSKDDTFKLRQGSAAVSALCPWICALLHLIVVHQSVHQPGKVNNSHQVRLLWTLRAFLLHPELQPYPKTTEYVLDVAASISDDLPEDARTQLLRHEANKPVHDPRIIFILGSPSTMQDSWLGLITPMQPQASGSANTPNQSTVSNPTNTAATSRSTAAQHQHQGFWQAQVQRTQAQQQRFGVAGASVVPNAGGMSGSGPTPPVEYGKPVPFQLRRWEILPDSTSGSGPNDTALSLTLFDAKKV
Length1559
PositionKinase
OrganismDiplodia corticola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Botryosphaeriales> Botryosphaeriaceae> Diplodia.
Aromaticity0.06
Grand average of hydropathy-0.294
Instability index47.50
Isoelectric point7.05
Molecular weight172297.97
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11048
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.84|      17|     170|     959|     976|       1
---------------------------------------------------------------------------
  959-  976 (27.51/19.00)	KTFDRHMsDTISSLILSD
 1137- 1153 (32.33/18.06)	KMFDALM.DPSSSLGLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.02|      28|      92|    1427|    1460|       2
---------------------------------------------------------------------------
 1427- 1460 (39.25/42.13)	GSPSTMQ.DSWlgLITPmqPQASGSAntPNQSTVS
 1522- 1550 (49.77/30.25)	GKPVPFQlRRW..EILP..DSTSGSG..PNDTALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.45|      37|      92|     251|     300|       3
---------------------------------------------------------------------------
   52-   94 (62.32/23.66)	KQPSADAPPKKANQQDDPR..WVapdTQFAAQdgfSRPPPRGRPQ
  252-  290 (65.13/49.85)	REPSSFKPPPRITVKDTQReeWL...RDLANP...SLPPKRRIPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.50|      37|     170|     993|    1029|       4
---------------------------------------------------------------------------
  993- 1029 (54.41/40.54)	LSLENFIS.......FSESTIGVLKKRNLSAAANASLHVLDAIL
 1260- 1296 (54.54/40.67)	SSKEGYER.......MLQRYLSVLNLTAWSIEDKAQGQICTAIL
 1300- 1343 (49.55/36.12)	RTLHELLSqaaqlgpAGDSKDDTFKLRQGSAAVSALCPWICALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.20|      21|     107|       9|      32|       5
---------------------------------------------------------------------------
    9-   32 (37.58/30.04)	AAQRATA....GNLPRPPiqgRPAVQQH
  114-  138 (35.62/19.88)	AALRSTAiassGSLPFPP...RPGLRVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     349.81|      99|     107|     469|     574|       6
---------------------------------------------------------------------------
  393-  468 (78.20/43.32)	..................LDWLLTS.........LES..TEIERLPVW.FLMVQ...........IYWQDLvtvrrrgrrlaEAL..LLQLGSITKgdDPDV.DD........PLVQRSQ.......QLITALIQ
  469-  574 (153.76/115.03)	GHRnCMVIPRTWKKHKrILESMLTSstqpALQSALRSIIRRNERLSGWsYKPTQ...........THQSPQ...........KAI..LSALDSVAL..DFDL.KDLA..TRCLAIMPDTQGLAVTVLQWACSLYR
  577-  683 (117.86/70.09)	GHR.LYIAARLLRKWK.FMGA........DIDSAVLAVLSDEQKLKG..IKHRDffrlvaelvrsKHFSVG...........RYLqwLIASGSLSA..GGDVtKSEAcnVRLIAEIP.LQGLPEHVLNLRQTL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.29|      15|      15|    1472|    1486|       7
---------------------------------------------------------------------------
 1472- 1486 (29.92/17.27)	TAAQHQHQGFWQAQV
 1489- 1503 (26.37/14.35)	TQAQQQRFGVAGASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.49|      11|      15|    1053|    1067|       8
---------------------------------------------------------------------------
 1053- 1064 (16.10/17.24)	LCQNSQGTAlQL
 1071- 1081 (20.38/ 6.01)	LCSDSRDSN.QL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     183.93|      46|     109|     796|     841|      15
---------------------------------------------------------------------------
  796-  841 (75.91/53.16)	LQSGDTMILAAIADTLNHHHRTFAAIGALRPLFNGLVE.QYGKF..RLE
  862-  900 (43.01/26.59)	...EPNLVLQLTSDITRLEQR..SAVAACSPASDNMSDfHSGKM.....
  910-  954 (65.00/44.35)	LASGTTMDENMVARVFA...RVVSRIGEQTGKEDGRNS.RYGQWlqRLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.86|      14|      16|     315|     329|      16
---------------------------------------------------------------------------
  315-  329 (23.32/20.34)	AKCVG..ANEMRaWMRK
  331-  346 (20.54/11.85)	ASSTGgmGGELK.WVRE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11048 with Med12 domain of Kingdom Fungi
Unable to open file!