<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11045

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMFGMGAGVRAQPRGRRAQERLQACSGERCRAGFALLHGTHGQRWHARRPRLVYFDRSKGRQAMCRARQLRGRMLRNLIVRTTRGGEERSSAAKTGSEKAGRIGGERPSPPAASSLAFFPSTSPQGAHADHTHPSPPTAQTLSPHPVDAQRALAASPHPAGRRTKPLRGLHLPAPLRVASAAWLPHSSAPAPRPRPQTIAASTQHLPQFSKIPLAERKAEDGLEGVQGSYGDGADGAKGRSMPGIVSMDRNGAQGASLGKLDDRALAASAAAHSKLNGDVPLPHVDRPSDMNGKATTNGAASQSQSPPADLSQLPPELVHFTEFYMPFGKLVERVAQETNVSLSELLDKMSNLQISSTPAINGVNGHAVNGAAPQSRDNEEKKTLMLNWAWGEREKFIKLLVLSKWSRSCEDVSKMIDLNAWLTEQMNHYEEAPKWIGQLKLNMDLAKAPNPDLKTALEVLSTGKAPWMPDLGYLPAEPLTPQQMLKTVTNLNALLAIRINLHEELPRQMKDWSIASGRATFRVPSEFQLDVSIADEDPSSSFFIVDLQFLFSPKPEVPDGWFRDWVEPQANLVLANTGLSGIYDWLHGFVLTHKLTTLKMQAYELAHTSWANSIHVQQVHRSLTVQYWTGTSGAKSWIEIGISSGKSKDGKVSWRGPSPPQLTLRWTRKGVPVETIPLKIDWTELSLENILKAIIALHISFILESIRNQLSTLSEKRSGLSMETITSPAEPADCCLHLRPGRTSKATEVRIDPISGGLSLRPVTPFSLHLERTMKDIAMDAASKIETLICNDLQNRVDKEAYNVGWTKLTHINIRPEATSASVQQKVVAQSFYRCPNWLSRWVLGLTVNLDGENWWILELSNESIGNGIQEVIPLLGTAPSGRKQPLSYKFLRAVEEIASAQFTFAIAIKELRRMHVPNVLRIVRDQKRKKNPTDRPVPQVTPALFIKSGPLLGEKEGHNSWAGEILRLHHKGLDTNTGCVVHAVKGQMSQGHVDFNLVSSQAGDVSFNSDGTFEVRLRTPFGEPFLEKIINRLKRIERLGRIVDVAKDQKLPCSEISLSRVVFRYCGNYKADIRFPEGSPVELHISPNNPHRRVAAFLKNVLNHRDSSKAFPYFMKILSQTLPLLRGFEAMESSAPAPASMPQPYINPRSLDWYRICYENPMTTFDIRLRTRHDSMEWHIHDSTNQQAHPRSPEFVAAMKDVLKQSGDKWIGVRTGIVAKIEGVEGALKKLDEVVKKHQKPVVDRPVGGAGPAQQVTGPSQQIKPQTQGQAKLPNQPPAIKPDPEVIMLD
Length1291
PositionTail
OrganismDiplodia corticola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Botryosphaeriales> Botryosphaeriaceae> Diplodia.
Aromaticity0.06
Grand average of hydropathy-0.423
Instability index48.97
Isoelectric point9.55
Molecular weight142878.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11045
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.70|      23|      23|     106|     128|       1
---------------------------------------------------------------------------
  106-  128 (44.20/18.22)	R.........PSPPAASSLAFFPSTS.......PQGAHA
  132-  153 (39.61/15.66)	H.........PSPPTAQTLSPHP.VD.......AQRALA
  162-  200 (25.88/ 7.98)	RtkplrglhlPAPLRVASAAWLPHSSapaprprPQTIAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.48|      14|      46|     661|     676|       2
---------------------------------------------------------------------------
  663-  676 (26.40/19.98)	TLRWTRKGVPVETI
  712-  725 (22.08/ 8.11)	TLSEKRSGLSMETI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     306.90|      70|     339|     607|     691|       3
---------------------------------------------------------------------------
  272-  330 (82.41/41.76)	HSKLNGDVPLPHVDRPSDMNGKATT.....NGAAS.......QSQSPPADLS...QLPPEL..........vhftEFYMPFGKL.....
  607-  690 (113.50/61.51)	HTSWANSIHVQQVHRSLTVQYWTGT.....SGAKSWIEIGISSGKSKDGKVSWRGPSPPQLtlrwtrkgvpvetiPLKIDWTELSLENI
  959- 1030 (110.99/59.93)	HNSWAGEI.LRLHHKGLDTN..TGCvvhavKGQMSQGHVDFNLVSSQAGDVSFNSDGTFEV..............RLRTPFGEPFLEKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.17|      21|      23|     462|     484|       4
---------------------------------------------------------------------------
  462-  484 (37.33/21.02)	TGKAPWMPdlGYLPAEPLTPQQM
  580-  600 (32.84/13.12)	SGIYDWLH..GFVLTHKLTTLKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.03|      13|     340|     728|     740|       6
---------------------------------------------------------------------------
  728-  740 (27.24/16.61)	PAEPADCCLHLRP
  750-  762 (23.79/13.50)	RIDPISGGLSLRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.21|      17|      45|     883|     903|       7
---------------------------------------------------------------------------
  883-  903 (22.73/26.60)	RKQPLSykflRAVEEIASAQF
  930-  946 (31.48/21.84)	KKNPTD....RPVPQVTPALF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.41|      15|      29|     375|     390|       8
---------------------------------------------------------------------------
  375-  390 (24.03/18.28)	SRDNEE.KKTLMLNwAW
  406-  421 (25.39/13.05)	SRSCEDvSKMIDLN.AW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.83|      50|     192|      15|      74|      13
---------------------------------------------------------------------------
   15-   74 (70.54/74.75)	RRAQERLQACSGERcraGfallHGTHGQRWHArRPRLVYFDRSkGRQAMCRARqLRGRML
  216-  265 (87.30/55.73)	RKAEDGLEGVQGSY...G....DGADGAKGRS.MPGIVSMDRN.GAQGASLGK.LDDRAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11045 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AASAAAHSKLNGDVPLPHVDRPSDMNGKATTNGAASQSQSPPADLSQ
2) AMCRARQLRGRMLRNLIVRTTRGGEERSSAAKTGSEKAGRIGGERPSPPAASSLAFFPSTSPQGAHADHTHPSPPTAQTLSPHPVDAQRALAASPHPAGRRTKPLRGLHLPAPLRVASAAWLPHSSAPAPRPRPQTIAASTQHLPQFSKIPLAERKAEDGLEGVQGSYGDGADGAKGRSMPGIVSMDRNGAQGASLGKLDDR
3) DEVVKKHQKPVVDRPVGGAGPAQQVTGPSQQIKPQTQGQAKLPNQPPAIKPDPEVIM
266
62
1233
312
263
1289










Molecular Recognition Features






MoRF SequenceStartStop




NANANA