<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11035

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSELSGGSAELPLALRPAPSSSDADESLMTQLQRISAQFGQFRHMDEDKLAEMAAAQQAGLADAEEAQDDDEEAGDDAKKRADELREAKADMFKHINDAQQEILYTIDFLGLLLSKDNPRGSNYMSPTLKQSGVPEGSFSYDKWPVKQLDERQKKQQDLVAKGWTMEGLGASADSLLQAATKLEKEVRKETQYWGQILSVKKRGWSLRRVPRESGTLGVQFGFLEASDRFQARGFAPLRAKEDGNIILDQALVQKPKTIRVRIVECGKTVGTSEQNNLVFAQQSDLEIEDLIRRARDSLFEQELFHEMTMETRQLLSYKTQFRDHVIIIPANPEYEASEPGQKREIHVDLIGVEDAEELLSRRPEDGLANDVALTLRLLLTYIHSQRLRKRTQQPLPMTDRPRPEPQLPIIRIMLNFIYHYNTATALRSHLSSIQHVLARAGISLNINLESAYANLSEAINTVHSDRSRLPQLDALMTVLSRPLHTTATFSLPSTLDEAAALRQELTVTLRTPIAPHIQGTDISLTIPPALAGILYRDNRQAQKRILSFDALDALQEYIDHAMSMDLSLNLAMRDRSNLQARNAKNRLPELSYFVRRGENKEAVMLQLATHISGKEGCLKVRWYALDAQLGGDEAVWRKDDGESRSFKEVVGAFLNVSLPS
Length663
PositionHead
OrganismDiplodia corticola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetes incertae sedis> Botryosphaeriales> Botryosphaeriaceae> Diplodia.
Aromaticity0.06
Grand average of hydropathy-0.473
Instability index55.47
Isoelectric point5.63
Molecular weight74487.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.98|      38|      43|      20|      60|       1
---------------------------------------------------------------------------
   20-   60 (58.33/44.69)	APSSSDADESLMTQLQRisaQFGQFRHMDEDKLAEMAAAQQ
   66-  103 (61.64/39.62)	AEEAQDDDEEAGDDAKK...RADELREAKADMFKHINDAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.82|      27|      39|     365|     403|       2
---------------------------------------------------------------------------
  364-  391 (40.99/49.50)	R.RPEDGLANdVALTLRLLLTYIHSQRLR
  403-  430 (44.83/22.64)	RpRPEPQLPI.IRIMLNFIYHYNTATALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.95|      25|      44|     432|     456|       3
---------------------------------------------------------------------------
  432-  456 (41.91/28.80)	HLSSIQHVLAR.....AGISLNINLESAYA
  474-  503 (35.04/22.90)	QLDALMTVLSRplhttATFSLPSTLDEAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.33|      37|      44|     512|     551|       4
---------------------------------------------------------------------------
  512-  551 (53.98/47.65)	LRTPIaPHIQGTDISLTIppALAGILYRDNRQAQKRI..LSF
  557-  595 (58.36/38.52)	LQEYI.DHAMSMDLSLNL..AMRDRSNLQARNAKNRLpeLSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11035 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DEDKLAEMAAAQQAGLADAEEAQDDDEEAGDDAKKRADELREAKADM
2) MADSELSGGSAELPLALRPAPSSSDADESLMT
48
1
94
32










Molecular Recognition Features






MoRF SequenceStartStop




1) SAELPLALRPAP
10
21