<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11029

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSYAPPPSSVHAGPVSSPSSPVADRTKTHQLYQQDHPKDQTPHTPTSPPLMSVSAQNYASSFSTTRTSPAQTFQPASLSSPPSSVAMSTQVSQQPTVTSTASFPTPASSAGGHFANNHTTDEAEGISKNGTTHSHKDGESYTGKEIGSDVMDIDTSEHRRTDHDRQNSGTGKIPDDNTMDLDYRAASSTQEEELNLTALRQDIGTAFHLCKSSYTASGPNPSLDLISLYGLGPVASSVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKADPGATGGLKYLTLWPEEEWRNQKVYGKDIKVAEPDSSFFRQQLKAMKMEPGTLPNHEIWEDALGHEKASKVTVANEASLAKAASTVPRAIRQPAHTNGTPSMISTPTAEYTRPKRTGKKRSYNDSSFVGYGEGFPDDEVDLDSGRYSNSEEGGRGLGKKKRKKVPR
Length440
PositionHead
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.06
Grand average of hydropathy-0.863
Instability index44.14
Isoelectric point8.33
Molecular weight47417.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11029
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.30|      29|      30|     126|     154|       1
---------------------------------------------------------------------------
  126-  154 (51.08/28.87)	ISKNGTTHSHKDGESYT..GKEIGSD.VMDID
  163-  182 (24.09/ 9.91)	.........HDRQNSGT..GK.IPDDnTMDLD
  199-  228 (38.13/19.78)	LRQDIGTAFHLCKSSYTasGPNPSLD.LISL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.04|      29|      30|      40|      68|       2
---------------------------------------------------------------------------
    5-   27 (25.28/ 8.41)	..........PP...PSS..VHAGPV...SSPSSpvADRTK
   40-   68 (55.80/27.07)	QT..PHTPTSPP...LMS..VSAQNY...ASSFS..TTRTS
   71-  109 (32.96/13.11)	QTfqPASLSSPPssvAMStqVSQQPTvtsTASFP..TPASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.89|      47|      88|     263|     312|       3
---------------------------------------------------------------------------
  263-  312 (77.19/46.21)	LGLaGRNKPVKA....................DPGATGGLKYLTLWPEEEWRNQKVYGKdiKVAEPDSSF
  335-  401 (72.70/35.42)	DAL.GHEKASKVtvaneaslakaastvprairQPAHTNGTPSMISTPTAEYTRPKRTGK..KRSYNDSSF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11029 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KVTVANEASLAKAASTVPRAIRQPAHTNGTPSMISTPTAEYTRPKRTGKKRSYNDSSFVG
2) MSYAPPPSSVHAGPVSSPSSPVADRTKTHQLYQQDHPKDQTPHTPTSPPLMSVSAQNYASSFSTTRTSPAQTFQPASLSSPPSSVAMSTQVSQQPTVTSTASFPTPASSAGGHFANNHTTDEAEGISKNGTTHSHKDGESYTGKEIGSDVMDIDTSEHRRTDHDRQNSGTGKIPDDNTMDLDYRAASSTQEEELNLTA
344
1
403
198










Molecular Recognition Features






MoRF SequenceStartStop




1) EEGGRGLGKKKRKKVPR
2) SSFVGYGEGFPDDEVDLDSGRYS
424
399
440
421