<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11020

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMEDSIDVDDLFGDPTSLELGLEGAAPTIKGLPQRLDELRLSGCSQKVAWSKLGAIAYVSQDGQKVLLRYLHCRPDDGKWTLSEEAPINQVSDAHGGHTIVHLLWNESGSELAIVDSGGRISIVTILTTLNTINFARQASIDSDDDWAQPVGLMWLNVNRPLFGFHKATRTNDRWNYPAYRRRPLGPLHPVNKPGLVLVTKSGHIKLIYQNPDMRWAEISTELKTVGYLDGLLTHAAMAPAEGSGISIATHSACGKICFYRVQVKWDPQEWDQTAKPSGTANNAFPTPGFQVLHTKTEIMSTVFHPSAHDVDNIAGFSPANGAIYNLTHLEIITAPQVLPGTQAASGPCILAVASMPAHNQVDPPPPSRPSSVLARWQLDTMAQALHPSFDDVVSKKTASNLKSKIVLRRLDDICFDRFVISTDYTEAGSVLAITFDDSSISFFEARSMRPINENDDVSVVTSMPNAGFTFPIDSSGLHIAFSPSGCLAVVLDGDWQLHLRYMEHSFGMEDGMYDNGKFSCAIAALALGYVRACGSDASADDILTVIVRQLNPDARKSFVTEVYSILFMSVDFTEQDKLVNNQSIQKGLSMQAVLGFKSRFQPRAPSSAVPWIILNIRQIMMLVLTFSHYLKNGRDSTPYEPEVLRMVLGNVKWILDLAKYLVDGLLEIADTLPADRNSFSLSSKTYESPALILVLSSVPRSFLRHIFRHLSRFPLTFKAANNLSGESYQLFASISSTIEQSSLKADVCEKMLAHIDSLVARSYETAGFGNAERNAPEREMLITCSIPPVLQPAVMSVLAETMAQIVRPEVDRMALALYDYSWLGVGDDKRTEHFKRTHDVDILKRNVSKLLDPTVAKRRCVRCCEISADASLPRSVSMYRWIGKIGVLRTCVCGGSFAMENVEGVNRAPFSVFR
Length918
PositionTail
OrganismEmergomyces pasteurianus Ep9510
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces.
Aromaticity0.08
Grand average of hydropathy-0.067
Instability index46.99
Isoelectric point6.13
Molecular weight101290.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11020
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     384.51|     122|     134|      52|     176|       1
---------------------------------------------------------------------------
   52-  176 (202.36/138.70)	AWSK..LGAIAYVSQDGQKVLLRYLHCR.....PdDGKWT.LSEEapINQVSDAHGGHTIVHLLWNE.SGSELAIVDSGGRISIVTILTTLNTINFARQASIDSDDDWAQPV.GLMWLNVNRPLFG..FHKATRTND
  182-  315 (182.15/114.77)	AYRRrpLGPLHPVNKPGLVLVTKSGHIKliyqnP.DMRWAeISTE..LKTVGYLDGLLTHAAMAPAEgSGISIATHSACGKICFYRVQVKWDPQEWDQTAKPSGTANNAFPTpGFQVLHTKTEIMStvFHPSAHDVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     320.94|     104|     443|     318|     434|       3
---------------------------------------------------------------------------
  318-  434 (157.45/117.83)	AGFSPANGaiyNLTHLEIITAPQVLPGTQaasgPCILAVASmPAHNQVDPPPPSRPSSVL..ARW...QLDTMAQALHPSFD.DVVsKKTASNLKSKIVL.RRlddiCFDRFVISTDYTEAGSV
  770-  880 (163.49/91.94)	AGFGNAER...NAPEREMLITCSIPPVLQ....PAVMSVLA.ETMAQIVRPEVDRMALALydYSWlgvGDDKRTEHFKRTHDvDIL.KRNVSKLLDPTVAkRR....CVRCCEISADASLPRSV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.04|      14|      41|     604|     617|       4
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  604-  617 (27.35/16.25)	FQP...RAPSSAVPWII
  643-  659 (21.69/11.40)	YEPevlRMVLGNVKWIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.55|      32|     162|     550|     582|       5
---------------------------------------------------------------------------
  550-  582 (52.22/39.38)	IVRQLN..P...DARKSFVTEVYSiLFMSVDFT.EQDKL
  710-  747 (41.33/25.81)	IFRHLSrfPltfKAANNLSGESYQ.LFASISSTiEQSSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11020 with Med16 domain of Kingdom Fungi
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