<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11018

Description Uncharacterized protein
SequenceMISHSSSHRPPSRPAAASRGSSSHSVPYPASDSYSAIDSRAQQIEVIDLTESDGGGMADIGRPAKRPRLDVGNEAPQSSLDHHHNQHQQQQYQNQDQPSSQHHVSSTTGEASVSSMNPLDLMNASSTERTGRPPWSFKGEIQRSSVEAQPEASQWPQSSSLPPLPIRPWKYGPQERYLAGTTGSKGGKECGEVKTTPYRIDVPSIAPRFADNKPVDFSPWRGSHPEDVLSEQTAKQGFYDRVSVSSNETTSAKSVVYPQFKNRSGLKLLSSVFAAALEKRQALCTITADSTFRPPPRVTLTDIKREAWLRDLANPAVPLRRLSRTIPHGIRGKVLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLEAKWVRDWTINVQQFVEGVIAGIGDANWRLKISYSIRLSARLFLDHLVEQDHFLEWFLMSLDNSSVDSLPVWLLMVGIYWANIVRYRKRGKRLAECLLEKLRLATETGQHAHLNPLTRRLSRLTKTFSLSHPSCFILPRCWDKYESVLSSCLDMNLPDDKAGFQNLKARNARVCRLANGRRKPAQSTNQRLIQLLDSSSDVATIGTECLNISQDYCTLVTKVIEWASTSFRYGLARIYTAVRVFRRWKKAGIDIDSHLLSFLVQDHRKSGVRFLDVYHVICELVRSQSFSVAKYLQWLMARGSVSNVLGCLQMHIPGDIGLLGHLPSSRLPSHIWNLRNTLLSRTGFSVALEVDTIQHIKASVRRRLPNMFPKAPPEGDAEMADDVDFSSLSWTVRSDIGNWIRDQVASHVKDSLKSTMDHDFGSEVKTSALIPQEFFEVRFILECLCDLSMLADVLKYASGSDNVTVLASAVDTLNCHLDSFNAIGATSDLFKSFTSAYAKISKTDLSVQDLIASLLDVAIKLPGELSTVSLLRRDLLQRDRKLAMAACSPVSDHIVDPLNTSNPTFSEELDQLLTSGNSMDEPTMGRIFDSLCKRFHAGSVNGEQCAHDTARYFAQLRPFNAKLFDNLMIKWVISVLRSSPRPNLSTILPPLIGVGCVTLHSFYVLARALLHSDAHKRTIPDLAELRISMIQLLDFRLSNGNGSQDLVTYRFKIARQEYIRQFSGEALSLIHDLLADLSEDGTDSLPKQFSNELLSTVVTPLLCEIIVRHPATIGADCGNRLLEKFPACINLTHRALGHLLTSQVQSGLVAAEETIESINDFSLPFCLMKLRLLFGFECDSSVKKRIYDVVFETAKSNMRKGQSHWIDVVGSLHADAAKEIRQRAEEQLLSHVLSSDYLPTSPTSESHTPPGCNVSALVCLRIVEDLSFSIPETGSPSLCPTLIEKMNMILQRITSLENNLMEASSSQDNDHAAAIRHAHAVQQSSIIIFWFSVLLRLIAIHRSRFAPGTLSKSDLADQTRLLISINCIALSRTLSPKTGPRPFLSINPLTPTTSPSQEPRSHFPFHATDTGISTSLQTQALDVAATLLDSIPDDCRHQCVRFLRDRCPPFLHPQNDPRLLFLLGPLTAENHPSSAATQSSQKQPGGSTLSQANPGTPGTPVTPSAAASVGTAASSSSSQQFQGCNSYNPVAFNPFDDQNSIIGKLRVQQRGQIAGPYPLRPWEMLEESAPVIGVNDTAVNLGWFAARRVRGDVA
Length1634
PositionKinase
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index48.85
Isoelectric point8.56
Molecular weight180670.56
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11018
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.56|      17|      19|    1405|    1423|       1
---------------------------------------------------------------------------
 1405- 1423 (28.52/21.04)	INciALSRTLSPKTGPR...PF
 1426- 1445 (30.05/14.95)	IN..PLTPTTSPSQEPRshfPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.23|      18|      26|    1100|    1125|       2
---------------------------------------------------------------------------
 1100- 1117 (30.89/30.95)	RQFSGEALS.LIHDLLADL
 1127- 1145 (27.34/ 9.24)	KQFSNELLStVVTPLLCEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.72|      23|     173|     318|     342|       3
---------------------------------------------------------------------------
  318-  342 (38.87/24.25)	PL.RRLSR.....TIPHGirGKVLLDQCLGK
  492-  520 (36.85/17.39)	PLtRRLSRltktfSLSHP..SCFILPRCWDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.09|      12|     277|       2|      13|       4
---------------------------------------------------------------------------
    2-   13 (24.01/10.47)	ISHSSSHRPPSR
  286-  297 (24.08/10.52)	ITADSTFRPPPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.59|      53|     276|     655|     753|       6
---------------------------------------------------------------------------
  699-  751 (92.22/102.64)	LGHLPSSRLPSHIWNLRNTLLSRTGFSVALEVDTIQHI.....KASVRRRLPN.MFPKA
 1176- 1234 (77.37/23.58)	LGHLLTSQVQSGLVAAEETIESINDFSLPFCLMKLRLLfgfecDSSVKKRIYDvVFETA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.25|      44|     178|     777|     860|       7
---------------------------------------------------------------------------
  777-  829 (64.35/76.61)	GNWIRDQVASHVKDSLkstmdhDF..GSEVKTSALIPQefFEVRfILECLC...DLSM
  956-  971 (13.08/14.20)	GNSMDEPTMGRIFDSL..........................................
 1266- 1308 (52.82/19.41)	.....EQLLSHVLSS.......DYlpTSPTSESHTPPG..CNVS.ALVCLRiveDLSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.54|      10|      21|     372|     381|       8
---------------------------------------------------------------------------
  372-  381 (19.14/13.27)	GVASGL.EAKW
  395-  405 (15.40/ 9.05)	GVIAGIgDANW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.73|      50|     166|    1309|    1358|       9
---------------------------------------------------------------------------
 1309- 1358 (85.92/59.54)	SIPETGSPSL.......CPTLIEKMN....MILQRITSLENNLMEAS..SSQDNDHAAAIRHA
 1470- 1532 (75.81/51.46)	SIPDDCRHQCvrflrdrCPPFLHPQNdprlLFLLGPLTAENHPSSAAtqSSQKQPGGSTLSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.98|      11|      19|     193|     203|      11
---------------------------------------------------------------------------
  193-  203 (20.52/11.33)	VKTTPYRIDVP
  215-  225 (23.46/14.15)	VDFSPWRGSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.03|      19|      19|     634|     652|      12
---------------------------------------------------------------------------
  634-  652 (32.09/19.64)	HLLSFLVQDHRKSGVRFLD
  655-  673 (31.94/19.51)	HVICELVRSQSFSVAKYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.78|      27|     479|     568|     613|      13
---------------------------------------------------------------------------
  568-  613 (30.78/60.62)	LIQLLDSSsdvATIGteclNISQDYCTlvtkviewastsFRYGLAR
 1069- 1095 (50.00/32.42)	MIQLLDFR...LSNG....NGSQDLVT............YRFKIAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.04|      21|     479|     894|     922|      14
---------------------------------------------------------------------------
  897-  922 (30.20/30.02)	VAIK....LPGELStvsllRRDLLQRDRKL
 1378- 1402 (30.84/12.16)	IAIHrsrfAPGTLS.....KSDLADQTRLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11018 with Med12 domain of Kingdom Fungi
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