<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11010

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVIDGFFDIFWRIYSIVAPESDGSKFGPVENSTLRNSNEIWSSLFALRNAGCLVSQLANRPELWIFSANPDFDALGRASGYQQPREDLIVAGNATFSYIASGVNTAAEINQHLLSGPDSSIFNGATTQNRLSPHVGEYSQLQSIATYSALYEALLSAISKTVTLQFTRQQKVIPLGTRTLYASLNENEYQSAEDSPFARKSTPFLSTLDINLTSKGRLVISLSTLPQPGLEQLHRNSESDITATRLNDDVWLAPSGTLCRLTSTSEYQSSLSSLVSPDPIGTTPHHAELPADKINANKREWKRSVSEWLEMFGLHLNNPESEFWVEVEVNVLDRPFYDLFFKLALNHEQSSPFIRILWPGRLCFSRSRSKLTAPANPTEFFSGQSESPLQFAERWVKEACRTSQPIEKHKSSDDQSELEIQQSKRSEPSPLRLDRSDMPESLARTINLPEAQLASAVYPTPPEGPLAQNMGAGIVSDRLGTSAIDPLSYAPTQTESIYNEAGGPTTYFRGNSEILPTAMDPASSELGIGSGLYDTAADEEFFGDMDVANFDTKGIITEADFNFFDEPDFTGLTDNLDMQAEEPEIGQQHSESNLATPYNSNTAMPMAEPSPPNTNQHHLITTKNGNGRMKQSTVSPLNTAAAEGKISEGISQFSQLVPTDGLRRQPMSPPLSPVQIKKILSPDVSSPLPSKSLNSKASKSCPAKNQYSPVIFQSTLWSSDKKYRMDGRFWFTPGRQHMTRNLRSYPSDIPTIGFPQKGKSVRPKPPSIHTSSGLLVSDKSLEIDLQSPSTSSYDSSDDDSDTDRESNASSPHIIQFHSKRKRDYESGGNSTPSHLERLTQASDIDNGPLDERQFAVLRIFLSGAVDWPLAGYFSRKQNDVFPVFSRREDLLQTAQLVVDQVTQSSFCHTHDDLHMSEWVDRDDVLSQSLFENTDSLGHMSKLDLRNYATLEDGPNPRKEMPSIRPSIPGSICKICSPHVKVHRGNNYLEILSPAIGFWETFGLEPLQGEKNIIPLCIYPPNVTEAADAFMERLSLVYSSGNFGRHTRPNKGNGLVPWSLNAASDQDYASLMHALNVSCEILGSALSTISATDENVVIYIINPFVYDAAIVDICSAFLRLFHKYVGDADRQHTRRLNELVLQIIPLEFIASPDSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCAPPLVLADPVPKVVPFRLAPESITPLEEFKCLHVAYSQSVDQRWVTAAWTDNSGRHQTALSYCLRERNSPVSRPISEIRTQIWETTKDIMDMSSSHWRLIIVKDEPTDSEEVDMWKSLLDQYNRHKAVKVELGIVSVSTKPGLSLRLPSSPLQFSALSQQPTQSGLSTVTPGSTPRPIPSPDPSGPAATPPTATTPMFADQQQATTPQPQQLFTDADQDTILIDKSDETWGVTLSHRLNNSYSLTKYQPALASGYLLRRSGTSDTDGQAVMTVNVIYTNSRRPIDHLLKDILRMYRELITLARVRGIVHVQGDWPLPWHIMTAVKGQEVLSYTL
Length1530
PositionKinase
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.420
Instability index54.77
Isoelectric point5.31
Molecular weight169782.28
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11010
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.39|      18|      21|     910|     928|       1
---------------------------------------------------------------------------
  910-  928 (32.15/27.27)	DQV.TQSSFCHThDDL.HMSE
  933-  952 (25.24/14.83)	DDVlSQSLFENT.DSLgHMSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     314.04|      93|     146|     211|     306|       2
---------------------------------------------------------------------------
  211-  306 (149.98/79.21)	KSTP..FLSTL...DINLTSKGRLVISLS....TLPQPGLEQLHRN...SESDIT.ATRLNDDVwLAPSGTLCRLTST...SEYQSSLSSLVSPDPIGTtpHHAELP...ADKIN
  360-  458 (133.96/61.57)	QSSP..F........IRILWPGRLCFSRSrsklTAPANPTEFFSGQ...SESPLQfAERWVKEA.CRTSQPIEKHKSSddqSELEIQQSKRSEPSPLRL..DRSDMPeslARTIN
  717-  760 (30.11/ 7.61)	QYSPviFQSTLwssDKKYRMDGRFWFT..........PGRQHMTRNlrsYPSDI.............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     316.10|      96|     839|     484|     584|       3
---------------------------------------------------------------------------
  484-  584 (155.38/88.80)	GIvSDRLGTSAI..DPLSYAPTQTESIYNEagGPTTYfrGNSEILP.T......AMDPASSELGIGSGLYDTAADEEFFGDMDVANF.DTKGIITEADFN..FFDEPDFT.GLT
  639-  684 (33.68/10.24)	.....RMKQSTV..SPLNTA..AAEGKISE..GISQF....SQLVP.TdglrrqPMSPPLSP....................................................
 1338- 1429 (127.04/60.84)	GL.SLRLPSSPLqfSALSQQPTQS...............GLSTVTPgS......TPRPIPSPDPSGPAATPPTATTPMFADQQQATTpQPQQLFTDADQDtiLIDKSDETwGVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.25|      50|     837|     143|     203|       4
---------------------------------------------------------------------------
  143-  203 (65.33/74.10)	SPHVgeysQLQSIATYsalYEALLSAIS..KTVTLQFTRQQK.VIPLgtrTLYASlNENEYQSA
  987- 1039 (81.93/55.51)	SPHV....KVHRGNNY...LEILSPAIGfwETFGLEPLQGEKnIIPL...CIYPP.NVTEAADA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.39|      18|      18|     781|     798|       8
---------------------------------------------------------------------------
  764-  778 (20.20/ 7.53)	...GFPQKGKSVRPKPPS
  781-  798 (27.99/13.31)	TSSGLLVSDKSLEIDLQS
  801-  817 (27.21/12.73)	TSS.YDSSDDDSDTDRES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11010 with Med13 domain of Kingdom Fungi
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