<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11007

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMKESLSLPLRPFVQRSVTEPDSLPIRIAQINSQRGSFRNVTEQSLQAEIDAQQATAAAGLEAEETEEAESQEAKSTDRLEQLFKSRAEIVDFVAQAHAEANYALDLVSLLISKYTPRQAEISMSPYLKQKAPLGSLGIDIIKTQEKTETTQKDIVDLSRGWKLETFDFAANKLLQAAFRLEQEVAAETKYWADVLSIKEKGWKICRLPRERQTLGVQCGFLEATPTLRDRGLAALRRGHGGDLILDRGLQPSQPRSLRVRVQQHNQIVGSSKLISLELVPGDNSIEHCIRLARDVLYEEELFHELNREARTLLQHGIESKGNLIQFQASDNQQILIDMVSLDEYNISDFDKQEHAEDALAEAVAQSLRLLLSHAHRKKYRRRARIPPPVTLKRRPNPEYSLLQPVVSYLQHKSALQWLKSVLGTITRTLQLAGLKCKHDVSPLIFVRLPPVNKTIPYPSEPDTLPFVERLVDTFLTPLESIVTGTLLTPTSSFKIRIITNISPNGYGTEFEIATNMTSGSRTKSSSSRFGLRDDLQQLLLHLYTTDLVYLIPALTLGTSTESSPLPTSSQQKQEQGQERLQPEQTHFNTPVQPHTSHPTPWTPTSPENGELVASFPTQRRSKKLNIDLRPERLTILCQWLGAGLADLGEDLESVAGEGNVIYSWSDDGGNERKTLQSIMCLLSQWETKPEL
Length691
PositionHead
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.06
Grand average of hydropathy-0.435
Instability index52.35
Isoelectric point6.09
Molecular weight77603.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11007
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.70|      36|      36|     558|     593|       1
---------------------------------------------------------------------------
  522-  544 (30.26/13.33)	........TKSS....S...........SRFGL...RDDLQQLLLHLYT
  552-  589 (58.82/32.67)	PALTlgTSTESSPLPTS...........SQQKQEQGQERLQPEQTHFNT
  590-  632 (36.62/17.64)	PVQP.hTSHPTPWTPTSpengelvasfpTQRRSKKLNIDLRPER.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.81|      11|      38|     153|     163|       2
---------------------------------------------------------------------------
  153-  163 (20.29/14.11)	DIVDLS.RGWKL
  193-  204 (15.51/ 9.05)	DVLSIKeKGWKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.89|      14|      16|     217|     232|       4
---------------------------------------------------------------------------
  217-  232 (21.51/19.80)	QCGflEATPTLRDRGL
  236-  249 (24.38/14.54)	RRG..HGGDLILDRGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.02|      33|      36|      31|      63|       5
---------------------------------------------------------------------------
   31-   63 (51.50/35.85)	NSQRGSFRNVTEQSLQAEIDAQQATAAAGLEAE
   69-  101 (51.52/35.87)	ESQEAKSTDRLEQLFKSRAEIVDFVAQAHAEAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11007 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TESSPLPTSSQQKQEQGQERLQPEQTHFNTPVQPHTSHPTPWTPTSPENGELVASFP
560
616










Molecular Recognition Features






MoRF SequenceStartStop




1) LPIRIAQI
23
30