<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11006

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSANGPRREVDQQLVDGTLSTTTSRAPHNNRNSSNGPSHTEAARLSNPSFDDSLPPELVHISQGFFSLGHLINRAAQQCWNDLTDLIAELAELQSTATHIASAPTSTTNGKHTPSQSATENAQRKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTANPDLAMALEVLSTRRVASMQESLFVPPKALTPKKKLKTLKKINKTIRTRLVLHDQIPSAFTHYLIHDGRVTFKVPMEFEVDLSIAQENPSSQFFFVDIRFLFSPSPPKPAGRLLDELDNRVNAMLMHSGLTGCYNLLHNLVLSNKITILFHQAIELARGHWLDTLRVEVLHRTLVVQYWANRPGPKSWVEIGIKSGRRKDQTQDGSITETPFLGLRWMKDNKEVESKYIKFDMELLSIEAVLRSVIALHVSFLLESTYTRLLQGRLYASGALSASLQMSISEPGDCLFDVQLTKGRNLRVMIEPVSGAIIFRPTPLLLNRHDIDRSFERPIVDDILLRISRLRSAAVIEEVESLADALGWEIVNSRDIKSEDLRRIFPPNILRSVLFFRKSWECNWGVAYTCSMDGDNWWVVELRAPSSDEGPVSPQSARMVTGRFGGLPERLSYGSFGKLDHALSGMLAIHANARYLSELHGIHHFPPVQNLSLGPHLQVPCVFIRFRSRSLPSGLQISPPINTNKNPAIKDTVRLSFQGIDLCTNFAILLAHGTLSREINDLALPAAHLDPTITFQPNGCGFAMRFLTPVGQPMIIQLLARLQQLERVISTLETLKQKSLKPLSVNLSKIKFAYAADEEARASINFNYHGQALDSDVNSITLLSKRTPLMLLRMSIDFPPQNPHRRIKESLTATLNGLRPAAGAGAGLEAVLQLLVITLPVLKALDRMTTGSHVGHPANSRLQITARSSKIFYIRYPSIRYRFCVYAGLRRDRVVWILREMTIAPDKVGRQALENKLKEHIYGAHGDGWQGLGNGAIAECEKIGNLLSALHGVIAEYISSGGGTSRSNTLGGRNGASGGGPSPGRGGSSGSNGGSGLGLEGRKAPQTQLSGRGAADNKARPMPGQVGMGMGIQGRPGGLGGANTPKPASNGIAIGTQTKTDTKAMKQNTKIPQSNKNNNATGAMANGNNGSGNGSGGSRDVDVIMID
Length1179
PositionTail
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.06
Grand average of hydropathy-0.225
Instability index44.27
Isoelectric point9.66
Molecular weight129279.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11006
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      97.54|      16|      16|    1032|    1047|       1
---------------------------------------------------------------------------
 1032- 1047 (29.90/18.96)	SGGGT..S..RSNTLGGRNG
 1049- 1065 (24.03/13.25)	SGGGP..SpgRGGS.SGSNG
 1082- 1099 (23.25/12.49)	SGRGAadN..KARPMPGQVG
 1100- 1109 (20.37/ 9.69)	MGMG..........IQGRPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.96|      33|      47|     298|     334|       3
---------------------------------------------------------------------------
  298-  334 (51.84/51.47)	IRFLFSPSPPKPAGRLLDELdnRVNamLMHSGLTGCY
  346-  378 (58.12/41.88)	ITILFHQAIELARGHWLDTL..RVE..VLHRTLVVQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.94|      27|     100|     744|     770|       4
---------------------------------------------------------------------------
  744-  770 (49.10/31.01)	HG.TLSREINDLAL.....PAAHLDPTITFQPN
  841-  873 (38.84/22.95)	HGqALDSDVNSITLlskrtPLMLLRMSIDFPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.46|      13|      15|     998|    1011|       5
---------------------------------------------------------------------------
  998- 1011 (21.05/20.26)	GDGWQGLgNGAIAE
 1016- 1028 (22.41/14.68)	GNLLSAL.HGVIAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.12|      16|      16|      40|      55|      12
---------------------------------------------------------------------------
   27-   45 (22.71/12.46)	LSTTTSRAPHnnrNSSNGP
   46-   64 (21.41/11.29)	SHTEAARLSNpsfDDSLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.70|      12|     100|     679|     690|      14
---------------------------------------------------------------------------
  679-  690 (21.76/11.12)	PVQNLSLGPHLQ
  697-  708 (18.94/ 8.71)	RFRSRSLPSGLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11006 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGIIMDGTSANGPRREVDQQLVDGTLSTTTSRAPHNNRNSSNGPSHTEAARLSNPSFDDS
2) TSRSNTLGGRNGASGGGPSPGRGGSSGSNGGSGLGLEGRKAPQTQLSGRGAADNKARPMPGQVGMGMGIQGRPGGLGGANTPKPASNGIAIGTQTKTDTKAMKQNTKIPQSNKNNNATGAMANGNNGSGNGSGGSRDVDVIMID
1
1036
61
1179










Molecular Recognition Features






MoRF SequenceStartStop




1) GSRDVDVIMID
1169
1179