<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11005

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDVPQSSSSHTGPPPSPSSPAVDPAQSRQLHQQNRSKDQTPHTPTSPPLMSVSAQNYASSFSTTQTSPAQIPRPASLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSVGGHFANNHTMDEAEGVSKNATADAQKNGESSIGKESGLDFMDIDPSEHRRTDHDRQKRSPGGNLDENTMDLDYRTASSSQEEEMSLAALQKDIGTAFHLCKSSYTASGPNPNLDIVSLYGLGPVAASVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKVEPGAPGGLRYLTLWPEEEWKNQKVYGKDIKVAEPDSSFFRQQLKAMKMEPGNLPNHEFWEDALGHEKPPKVIAAADVSMAKTAGTVPGSIRHPMHTNGTPPMVSTPTAENTRPKRTGKKRSYNDSSFVGYGEGFPDDEADLESGRYSNSEEGGRGPGKKKRKKDHISGVSPSLTERGGSYGVGMFGVGAR
Length464
PositionHead
OrganismEmergomyces pasteurianus Ep9510
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces.
Aromaticity0.05
Grand average of hydropathy-0.847
Instability index53.52
Isoelectric point7.82
Molecular weight49630.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11005
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.68|      29|      30|      47|      76|       1
---------------------------------------------------------------------------
   20-   43 (38.16/17.34)	SP......AVDPAQSRQLHQQNRSKDQTPH
   47-   76 (47.98/27.36)	SPPlMSVSAQNYASSFSTTQTSPAQIPRPA
   80-  107 (45.54/22.04)	SPP.SSVAMSTQVSQ.QPTVTSTTSFPTPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.28|      24|      30|     128|     154|       2
---------------------------------------------------------------------------
  128-  154 (34.07/24.01)	KNATADAQKngeSSIGKESGLDFMDID
  159-  182 (43.21/22.77)	RRTDHDRQK...RSPGGNLDENTMDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.53|      26|      30|     249|     276|       3
---------------------------------------------------------------------------
  249-  276 (38.94/26.81)	INRLRKSYEGKIKGLGLAGrnKPVKV.EP
  282-  308 (41.60/22.84)	LRYLTLWPEEEWKNQKVYG..KDIKVaEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.42|      50|      91|     309|     358|       4
---------------------------------------------------------------------------
  309-  358 (89.17/40.83)	DSSF..FRQQL..KAMKMEPGNL..PNHEFWEDALGHEKPPK.V.IAAADVSMAKTAG
  361-  391 (30.39/ 9.84)	...................PGSIrhPMHT.......NGTPPM.VsTPTAENTRPKRTG
  398-  452 (68.86/30.12)	DSSFvgYGEGFpdDEADLESGRY..SNSEEGGRGPGKKKRKKdH.ISGVSPSLTERGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11005 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDVPQSSSSHTGPPPSPSSPAVDPAQSRQLHQQNRSKDQTPHTPTSPPLMSVSAQNYASSFSTTQTSPAQIPRPASLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSVGGHFANNHTMDEAEGVSKNATADAQKNGESSIGKESGLDFMDIDPSEHRRTDHDRQKRSPGGNLDENTMDLDYRTASSSQEEEMSLAA
2) PKVIAAADVSMAKTAGTVPGSIRHPMHTNGTPPMVSTPTAENTRPKRTGKKRSYNDSSFVGYGEGFPDDEADLESGRYSNSEEGGRGPGKKKRKKDHISGVSPSLTERGGSYGVGMFGV
1
343
198
461










Molecular Recognition Features






MoRF SequenceStartStop




1) GKKKRKKDHISGV
2) YLTLW
431
284
443
288