<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11003

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDSIDVDDLFGDPTSLELGLESAAPTIKGLPQRLDELRLSGCSQKIAWSKLGTIAYISQDGQKVLLRYLHCRPDDGKWALSEVSQINQIADIHGGHTMVHLLWNESGSELAIVDSCGRITIVTIMMSLNTVNQPRQASIDPDDDLAQPVGLMWLNLNRPLFGFHKATRTNERWNYPAYRRRPLGPLHPVNKSALVIVTKSGHIKLIYQNPDLRWGEISTELKTVGYLDGLLTHAALAPAEGSGISIATHSACGKVCYYRVQVKWDPPEWDQTIKPGGGSIAFPTPAFQVLHTKTEILSPVFHPPAHDVDNVTSFSPPNGAIYNLTHLEIITAPQLLPSTQAATGPCVLAVASISPQNQLGQPSPSGPSSVLVRWQLDTMAQALHPSFDDVVSTKTASNPKSKIIFRRLDDIYFDRYVVSIDYTEAGSVLAITHDDSSISFFEARSMRPITENEDGNTVTSMPNAGFTFPIDASGLHIAFSPSGCIAVVLDGEGQFHLRYMEHSFGMEDGMYDNAKFTCAIAALALGYVRACGSDTSADDILALIVRQLNPDAQRTFVTEVYSILFMSVDFTEHDKLVNNHSIQKGLSMQAVLGFRSRFQPRAPSSTVSWIILNIRQIMVLLLTVSHYLKNGKDSTPSEPEVLRMVLGNVKWILDLAKYLVDDLLEIAHTIPADRTSFSLSSKTYESPSLILILSSVPRSFLRHIFRYLGRFPLTFKAANNLSGESYQLFASINNTIDQSSLKPDLCEKLLAHIDSIVTRTYEAAGFGNAERNAPEREMLITCSIPPVLQPAVMSIFTETVPLVVRPEVDRMALALYDYSWLGVGDDKRTELFKRTHDVDILKKNVGKVLDATVAKRRCVRCCEVSEDTSLPRSASMYRLIGKIGVLRTCVCGGSFVMENVEALDRLPLPVYR
Length913
PositionTail
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.060
Instability index43.08
Isoelectric point5.99
Molecular weight100876.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11003
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     448.31|     123|     133|      74|     199|       1
---------------------------------------------------------------------------
    4-  137 (165.22/106.26)	.SIDVDDL.FGDPT.SLeLGLESAAPTIkG..LPQ..RLDElRLSGCSQKiaWSKLGTIAYISQDGQKVLL..................rylhcrPDD...GKWALSEVS.QI..NQIADIHGGHTMVHLLWNE.SGSELAIV..DSCGRITIVTIMMSLNTvnqPR.Q
  138-  271 (184.28/111.84)	ASIDPDDD.LAQPV.GL.MWLNLNRPLF.G..FHKATRTNE.RWNYPAYR..RRPLGPLHPVNKSALVIVT.............ksghikliyqnP.D...LRW..GEIStEL..KTVGYLDGLLTHAALAPAEgSGISIATH..SACGKVCYYRVQVKWDP...PEwD
  272-  332 (48.58/23.11)	QTIKPGGGsIAFPTpAF.QVLHTKTEIL.SpvFHPPAHDVD...NVTSF...SPPNGAIY..NLTHLEIIT..................................................................................................
  352-  437 (50.23/24.18)	ASISPQNQ.LGQP..........................................................spsgpssvlvrwqldtmaqalhpsFDDvvsTKTASNPKS.KIifRRLDDIYFDRYVVSIDYTE.AGSVLAIThdDS......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     455.15|     149|     192|     549|     714|       2
---------------------------------------------------------------------------
  549-  714 (228.71/252.39)	LNPDAQRTFVTEVYSIL...FMSVDFTEHDKLVNNHSIQKGLSMQAVLgfrsrfQPRAPS...STVSwiiLNIR...QIMVLLLTVSHYLKNGKDS......TPSEPEVLRmvlGNVKWILD..LAKYLVDDLLEIahtipADRTSFSLSSKTYESPSLILILSS..VPRSFLRHIFRYLGRFPL
  742-  909 (226.44/197.84)	LKPDLCEKLLAHIDSIVtrtYEAAGFGNAERNAPEREMLITCSIPPVL......QPAVMSiftETVP...LVVRpevDRMALALYDYSWLGVGDDKrtelfkRTHDVDILK...KNVGKVLDatVAKRRCVRCCEV.....SEDTSLPRSASMYRLIGKIGVLRTcvCGGSFVMENVEALDRLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.63|      18|      19|     463|     480|       3
---------------------------------------------------------------------------
  439-  458 (23.79/11.85)	ISF.FEARSMRPIteNEDG.NT
  459-  477 (25.28/13.04)	VTSmPNAGFTFPI..DASG.LH
  478-  497 (20.57/ 9.29)	IAFsPSGCIAVVL..DGEGqFH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11003 with Med16 domain of Kingdom Fungi
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