<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP11000

Description Polynucleotide kinase 3'-phosphatase
SequenceMHELLLFAPVPAKQHHDLLQQLSGLTAMQPTRTFERRLVFKAYRKPGFIKTRPGGSQDVQAPETQRLNKLLNGSLYYIQVVGNVREQDFGSMPASSTSSSLPASSASLRSDVVPQGTGAGGDGTQQGQGSLSSSTPMNHGAAAAAVSKGYVAADQPWRLEFKDTPEAGARSGVTSRFVGSANLPSGNILPEMTAWGFDYVSEYVVEGHTFVLDDTVLFMHRVLTFPPSNDSGGGSPKTLAPTEYLPSLDKMVPLDTSGTYVLQASITVQDSGNPDMLKANSQRLLGLKEHLKSVVKLEPEDRLSLDTRSESQLHPRSVIISAIRFIMNGTKRNSPEERDISPPPTKRKAIGAATSAANFFTPLSQKKPEQVTWRTVSNSCIIGKYNQEQALEAVKSGVKRRIAAFDLDSTLIATKSGRRFATNQHDWKWWSPTVPGKLKELNDKGYLVVVLSNQKAISLKKDLKGGRLESKSLSIFKQKVAAVMQTLDVPFSIYAATENDEFRKPRMGMWREMLDDYDLDVASSLDLEQSVFVGDAAGREGDHSCVDRDFAANVGIPFKTPEEFFLNEASRPISRAFDPKAYVVGSSEDEPNITFSKKNDTELVIFCGSPGSGKSTFYWKYLEPLGYERVNQDILKSRPKCLKVAKEYLQAGKSVAVDNTNAGTETRAFWIELAKEVNFPIRCIYLSTPPQICKHNDAVRAANPKIESLNPESRTSLPGIAFGDFQRRFQEPTLSEGFQDITHVEFKFQGTPATKELWGQYWV
Length763
PositionHead
OrganismBlastomyces percursus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.09
Grand average of hydropathy-0.431
Instability index44.06
Isoelectric point8.56
Molecular weight84201.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
kinase activity	GO:0016301	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP11000
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.20|      19|     140|     350|     374|       1
---------------------------------------------------------------------------
  350-  374 (28.92/33.35)	IGAATSAANFftplsqKKPEQVTWR
  493-  511 (38.29/25.74)	IYAATENDEF......RKPRMGMWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.63|      20|     352|     273|     292|       4
---------------------------------------------------------------------------
  273-  292 (34.61/25.03)	NPDMLKANSQRLLGLKEHLK
  631-  650 (35.01/25.41)	NQDILKSRPKCLKVAKEYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.05|      33|     122|     529|     563|       7
---------------------------------------------------------------------------
  529-  563 (54.85/45.17)	QSVFVGDA.AGREGDHSCVdrDFAANVGIPFK.....TPEE
  653-  691 (48.20/32.40)	KSVAVDNTnAGTETRAFWI..ELAKEVNFPIRciylsTPPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP11000 with Med18 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFGSMPASSTSSSLPASSASLRSDVVPQGTGAGGDGTQQGQGSLSSSTPMN
88
138










Molecular Recognition Features






MoRF SequenceStartStop




NANANA