<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10998

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGAFTNFRAIDGFFHIFWRIYSRVAPESPESQLDSLENSALKSSNEIRSSILALRNIGCLVSQLTKRCDLWIFSADPNFDALRQVSMSRQPGEDLISAGNVTFLNAASGVNTAAEIKHRLLSEPQSSIFNSAAKQNNSMPSLGDYSQLQSLATYSAFYEAFISATSKALTLSFTKQQKVIPLGTRTLYSSLDENGHRSGEDDSPCAQKFTSFLSTLDINMTSKGRLVISLSTLPQPGLEQLCRGSESDKPATCPNDDLWLAPSGILCRLTSIEEYQSTPSNIVSSGHVGATRHEAELPAGKNIANTREWKRTVTEWLKTFGLYLNDPETELWVGVEINMLDRPFHDTFSKSTSNHRTALPFIQILWPAKLCFSRSRSKVTVPINPTEFFSGQAESPLQFAERWVNEPFPRGHPFGHNKTSDGSSEHEKQQPKPSAPSPPRLDRSGIPESLARTITLPEAQLASAVYPTPPGGALTQNMGATIVSETLGASTTDALNYPSAQSDSIYNETSGSTAYFRGNSELLHPSLDGAPPELGIGSGLYDTAADEDFFGAMDVANFDSKGITEADFNFFDEPHFAGVAGDLDMKTEEPETLQQHTESNFTTPYNSNTAMSITEPDHSNTDQSHSLTTSNGDAYIKRSTVSSLVATAGDGQISGGTAELDHVASTHGRRRRPISPPLSPVQIKKILSPEVPPLPKSKSFKSEISKIHAVQNQYSPVIFQPKLWSSDKKYKMDGRFWFTPGRAHVTPNLSSYPSDIPTIGFPEKGRKGRRKPPLIRALSGPLVSENSPEADVQSPCVSSSDSSDDGSVTDRGSSPSSPPITAFHPKRKRDYDGGGNSTPSSLERHTQASDEDHKPLNEHQLALLGVFLSEAVDWPLTGYFSRKKNDVFPVFSRREDLLQIAQLVVDQITQSSLPHIHDDLHQPDWVDDWGDVLSRSLFDNNDDLGLMSKLDLRTYATLEDGPNSRKDTASLKPNVAGSICKICCPHVKVHRGSDYLEILPPAIGFWETFGLEPLQGEKNIIPFCIYPPNATEAADTFMDRLGLVYSSGNFGSHSRPNKVNGLVPWSLNAASDQDYTSLMHALNVSCENLGSALSNISATQENVVIYIINPFVYDAAIVDICSAFLRLFHKYVGDSDRHHPRQLNELVLQIIPLAFIASPDSIVVPTQMDYLRLALEVYSRCPPKDRSSDWLGCAPPLVLADPVPRVVPFRLSPESVAPLEEAKCLHVAYSQSVDQRWVTAAWTDNSGRHQTALSYCLRERDSPVSRSISEIRTQIWETSKEIMDMSSSHWRFMVVKDEPIGSEEIESKDTTLSAPSCGMHPSLTQASLVWKSLLDQYNRSKAIKVEFGILCINTKPGLSLKLPSVPLQFSTLSQQSIQNGPSTTTPGSTPRPVPSPDPSGPAATPPTANTPMFADQQQPTPQQTQQPTPDSDQDTILIDKSDETWGVTLSHRLNNSYSLSKYQPALASGYLFRRSGTSDTDGQAAMTVNIIYTNSRRPIDHLLKDILRMYRELATLAQARGIVHAQGNSSLPWHIMTAVKGQEVLCYTL
Length1553
PositionKinase
OrganismEmergomyces pasteurianus Ep9510
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces.
Aromaticity0.08
Grand average of hydropathy-0.421
Instability index55.70
Isoelectric point5.62
Molecular weight170682.09
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10998
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.64|      33|     194|     987|    1031|       1
---------------------------------------------------------------------------
  987- 1031 (50.57/56.95)	CCPHvkvHRGSDYLEILPPAIgfwetfGLEPLqgeKNIIPFCIYP
 1185- 1217 (66.07/38.83)	CPPK...DRSSDWLGCAPPLV......LADPV...PRVVPFRLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     339.79|     108|     194|     161|     303|       2
---------------------------------------------------------------------------
  161-  271 (174.09/95.62)	FYEAFISATSKALT.LSFTK...QQKVIPLGTRTLYS.SLDENGHRSGEDDSP..CAQKFTS..F..LSTLDINMTSKGRlVISLSTLPQPGLEQLCRGSESDKPATCPNdDLWLaPSGILC
  348-  466 (165.70/109.43)	FHDTFSKSTSNHRTaLPFIQilwPAKLCFSRSRSKVTvPINPTEFFSGQAESPlqFAERWVNepFprGHPFGHNKTSDGS.SEHEKQQPKPSAPSPPRLDRSGIPESLAR.TITL.PEAQLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.18|      31|     513|     911|     941|       3
---------------------------------------------------------------------------
  911-  941 (59.59/33.71)	QITQSSLPHIHDDLHQPDWVDD.WGDVLSRSL
 1426- 1457 (52.59/28.89)	QQTQQPTPDSDQDTILIDKSDEtWGVTLSHRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     230.58|      68|     101|     671|     744|       4
---------------------------------------------------------------------------
  671-  744 (116.43/74.66)	HGRRRRPISPPLSPVQIKKIlSPEV...PPLPKSKSFKSEISKIHAVQNQYSPVI..FQPKlwssdKKYKMDGRFWFTP
  771-  843 (114.15/59.92)	KGRRKPPLIRALSGPLVSEN.SPEAdvqSPCVSSSDSSDDGSVTDRGSSPSSPPItaFHPK.....RKRDYDGGGNSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.58|      15|      15|     630|     644|       6
---------------------------------------------------------------------------
  630-  644 (25.87/13.65)	SLTTSNGDAYIKRST
  647-  661 (25.71/13.53)	SLVATAGDGQISGGT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10998 with Med13 domain of Kingdom Fungi
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