<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10996

Description Uncharacterized protein
SequenceMIPHSSSHRPPSHPAPPSAGSSASSAHRATPETARTIDSSSQQNAVIDLTEPDFTDVADIARPAKRLRLDIGNEPPPPSLDYHHNQHQHQHQQPQPQQQQQQGEYYEIQSNPEHHGFSTTGEASSEFSMNPLDLMNASSTEQAARPPWSFGTDIPRPDTEGQPEVSQWPQFASLPPLPLHPWKYGRQERYLASTTQPKDNMKCGEVETTPYRIDIPSVAPRFADNRPADFAPWTGSQPEDVLSEQTTKQGFYDRVQVSSNESASARASLYTHFKHRSGLKILSSVFAAALEKRQAQCTITTASTFRPPPRVTLTDIKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLETKWVRDWTISVQQFIEGVIASFGDANWKLRVSYSIRLSARLFLEHLIEQDHFLDWFLASLDNASFENLPVWLLMVGVYWQNIVRYRKRGRRLAECMLEKLRLATETDLKGQLNPLTRRLSRLTKTFTQTHPSSFILPRSWAKYESVISSCLDMNLPDDRAVFEKLKARNIRLCRLQNSREKHTRPPHQRLIQLLDSSSDVPTICTECLNISRDYSILVTKVIEWASTSFRYGLARKYTAVRIFRRWKKAGIDIDFHLLSFLMQNHQKSGVQLLDVFHVICELVRSQSFSVAKYLQWLMARGVVSNISEFQQKHVSGGIGLLAHLPPCRLPSHIWNLRNTLLSRTGFSVTLESDTIQRIKASVRRRLPNMFPELSPNGDAEMTEDVDLASLSWTIRSEIGNWIRDQVASHIKDSLRSAMDRDFASEVKTSALTPQEFFEVRYILECLSDLSMLADVLKYASGSDNVTVLTSAVDTLNYHLDTFTAIGATSDLFKSYTGAYARISKTELSVQDLITSLLEVAIKLPAETSTVASLRRDQLQRDRKLAIAASSPVSDHIVETLNTANATFTEELDQLLASGNSMDETTMARIFDSLRKRLQAGSINGKQCAHEAARYFAQLRPFNAKFFDNLMIKWVISVLKSYPRPNLSAMLPPLVGVGCVTLHSFYVLAKVLLHSDAHRNTIPDLAELLFSMIQLLDNRLSNGNGSQDLVAYRFKIARQEYMRQFPGEALGLMQDLLAELSEGTTGSSPEQFNRDLLDTTLKPLLCEIMVRHPAVVGVDCAGRLQEKFPACMNLTHQALGCLLASQSQSGLVAAEETIESINDFSLPFCLMKLRLLFAFECNGDVKKRIYDAVFEAAKLNVHHGQSHWIDVVETLDADAAQEIRRRAEEQLLSLVLSADSLPTSPTSEANAPPSFNASALVCLRIVEDLSFSVPETGIPSLGPILLDKMNMILHKVTILENNIMNANTIQENDQAAATRDSHATQESVITFWFCIMLRLVSIHRSTFTPGTLSKSDLADQTRLLISIICITLSRTLSPKIPGQPHTFTSTVSSEPTTLASIPQPQPQPLLYGTKTGISTNLQTQALDVAATLLDSIPDDARQQCARFLRDRCPPFLHPQNDPRLLFLLGPVAADTQPSSSTTQSSQQQPVAPTPPQATPGTPATPATPTTTVSIGTAAPSSSSQQLLGGNIYNSTSFIPFDDPNSFVSKLRVQQRGRIVGAYPLRPWEMLEESAPVIGVNDTAVNLGWFGARRMRGDVTGCDWGDGC
Length1657
PositionKinase
OrganismEmergomyces pasteurianus Ep9510
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces.
Aromaticity0.07
Grand average of hydropathy-0.268
Instability index48.59
Isoelectric point7.41
Molecular weight184460.70
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10996
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.94|      28|      34|    1504|    1537|       1
---------------------------------------------------------------------------
 1504- 1537 (45.13/29.30)	PF..LHPQNDPrllfllGPVAADTQPSSSTT......QSSQQ
 1539- 1574 (40.81/17.29)	PVapTPPQATP......GTPATPATPTTTVSigtaapSSSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.72|      32|      34|    1384|    1417|       2
---------------------------------------------------------------------------
 1384- 1417 (46.24/31.20)	CIML.RLVSiHRSTFTPGTLSkSDLADQTRLLISI
 1419- 1451 (52.48/27.40)	CITLsRTLS.PKIPGQPHTFT.STVSSEPTTLASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     542.76|     181|     229|     427|     651|       3
---------------------------------------------------------------------------
  307-  424 (45.22/13.63)	...........................................................................................................................................PPPRvtltdikreAWLRDLANPSVPLRRL...SR...TIPHGIRGKVLLDQclGKSIP.............ICraiwlAKCVGANelrafkrkgtsagvasgletkwvRDWTISVQQFIEGVIASFgdaN...............W.........KLrVSY
  427-  651 (273.96/218.01)	RlsarlflEHLIEQDHFLDWF.....LASLDNASFENLPVWLLMVGVYwQNIVRYRKRG........RRLAECMLE....KLR..LATETDLKGQLNPLTrrLSRLTKTFTQTHPSSFilPRswakyesvISSCLDMNLPDDR.........AVFEKLKARNIRLCRLQN.SREKHTRPPHQRLIQLLDS..SSDVPT............IC.....TECLNIS.......................RDYSILVTKVIEWASTSF...RyglarkytavrifrrWkkagididfHL.LSF
  654-  853 (223.59/112.46)	Q.......NHQKSGVQLLDVFhviceLVRSQSFSVAKYLQWLMARGVV.SNISEFQQKHvsggigllAHLPPCRLPshiwNLRntLLSRTGFSVTLESDT..IQRIKASVRRRLPNMF..PE........LSPNGDAEMTED..........VDLASL.SWTIR.SEIGNwIRDQVASHIKDSLRSAMDRdfASEVKTsaltpqeffevrYI.....LECLS..........................DLSML.ADVLKYASGS....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.16|      10|      16|     103|     112|       4
---------------------------------------------------------------------------
  103-  112 (20.08/11.22)	GE.YYEIQSNP
  121-  131 (15.08/ 6.78)	GEaSSEFSMNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.01|      36|      38|     164|     199|       5
---------------------------------------------------------------------------
  165-  199 (60.03/31.22)	.VSQW..........PQFASLPPLPLHPWKYGRQERYLASTTQPKD
  205-  250 (49.53/24.45)	EVETTpyridipsvaPRFADNRPADFAPWTGSQPEDVLSEQTTKQG
  256-  284 (33.45/14.09)	QVSSN..........ESASARASLYTH.FKHRSGLKILSS......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.73|      16|     120|    1034|    1049|       6
---------------------------------------------------------------------------
 1034- 1049 (31.48/19.24)	RPNLSAML...PPLVGVGC
 1152- 1170 (26.25/14.80)	KPLLCEIMvrhPAVVGVDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.94|      53|     220|     854|     909|       9
---------------------------------------------------------------------------
  854-  909 (81.40/67.45)	DNVTVLTSAVDTLNYHLdtfTAIGATSDL....FKSYTGAYARISKTE.LS.VQDLITSLLE
 1074- 1132 (76.55/54.27)	DLAELLFSMIQLLDNRL...SNGNGSQDLvayrFKIARQEYMRQFPGEaLGlMQDLLAELSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.59|      26|      29|    1264|    1292|      14
---------------------------------------------------------------------------
 1264- 1292 (35.99/23.94)	TLDADAAQEIRRRAeeqLLSLVLSAD...SLP
 1296- 1324 (39.60/19.55)	TSEANAPPSFNASA...LVCLRIVEDlsfSVP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10996 with Med12 domain of Kingdom Fungi
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