<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10994

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEGLKSARSSSAQWKNLFHRCLSQRTDTSEFRDFAKLMLNRYSIPARRLLDLLLASRSVTNVPWDPLIPLYVDTLHRLESVRTEDILESLLAHSTVSQKQVSAQNGSAAKEPVSTLMTDYCIIHNATIAATSGYAPKTVADAVNTFSALAKWIFALLSWNSSHKPVGDPVGSLTKSPDALAVFESLGILFAALVSTEKSVSALSAPRSKGWRNKLGQALSEYIPLCAGVSIPLRDRLEVLRKDFNLYDHDSEKSLEDTMMENVNISALEFESNVLDGSIINSRAGPYIYVNALLFGRPLVDDNMMVNYLNNRYGGDRMTLIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCASAIDPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQLRREDLVAQINNSPERAEQLINELESMEGNAGAIAGAITEVMHSLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILQPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKHKYVLSHYDLGISNSDSFVLRLLQHGSSSQRLEDLDEKQKNNLGAWITALFIAEGISDESMSSCSPQEFYLLVATLFSQSLAARETGKLEFETLKGGFEYLLEPFLLPSLVMALTWLGHHIWESESDLTTSLKLLLCLVKPSSISGEAQEIHRTVLLITAKSLEDQLKSIRIRHPSRNDIKPILEALEPYRSFQRRSTARYGEVEGWAANPAGGGVVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPIDPSKDTVPRCPILTLRDALNVERDNIPKLIDSDMLRAELIVRLNRRVDALTAVTQMSQEVSNIDVGNIMQDINLEGEDMEMSDQRHHQGDEQPGQPDQGPDDAENLNDMLDAAVAAAAGEDGNENGQEMELGGIGGIGMGMDSGLDTSIDDVLNGADMGVGNPEFLDLDMEGMF
Length1041
PositionTail
OrganismEmergomyces pasteurianus Ep9510
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces.
Aromaticity0.07
Grand average of hydropathy-0.088
Instability index43.83
Isoelectric point4.84
Molecular weight114821.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364142

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10994
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.14|      23|      64|      90|     112|       1
---------------------------------------------------------------------------
   90-  112 (38.07/26.81)	LLAHSTVSQKQVS.AQNG.SAAKEP
  128-  151 (18.49/ 9.01)	IAATSGYAPKTVAdAVNTfSALAK.
  156-  177 (37.58/26.37)	LLSWNS.SHKPVG.DPVG.SLTKSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.81|      34|      64|     891|     929|       2
---------------------------------------------------------------------------
  891-  929 (48.03/49.47)	DNIPKLIDSDMLRAElivRLNRRVDAltAVTQMSQEVSN
  957-  990 (60.78/44.95)	DEQPGQPDQGPDDAE...NLNDMLDA..AVAAAAGEDGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.77|      31|      34|     380|     412|       8
---------------------------------------------------------------------------
  380-  412 (46.90/29.60)	ALSRIDPNAfpSFSEMFA...MQGNSILSDVRQEFL
  416-  449 (42.87/21.24)	ALHKLIPEA..SIERLLGenpMQTLPVGGQLRREDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.55|      68|     138|     489|     558|       9
---------------------------------------------------------------------------
  489-  558 (117.00/77.97)	CSRKETMTLKN..ICNSLSRRPLS.LDVMLLFISPSTILQP..LCALLDAWKW.GEEQGESQPvyDEFGSI.LLLVL
  625-  699 (98.55/59.43)	CSPQEFYLLVAtlFSQSLAARETGkLEFETLKGGFEYLLEPflLPSLVMALTWlGHHIWESES..DLTTSLkLLLCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.93|      21|     686|     314|     335|      10
---------------------------------------------------------------------------
  314-  335 (33.41/26.01)	GGDRMTLIEDLITAAFDVLsNG
 1002- 1022 (39.52/26.07)	GGIGMGMDSGLDTSIDDVL.NG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10994 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DINLEGEDMEMSDQRHHQGDEQPGQPDQGPDDAENLNDMLDAAVAAAAGEDGNENGQEMELGGIGGIGMG
2) SGLDTSIDDVLNGADMGVGNPEFLDLDMEGM
938
1010
1007
1040










Molecular Recognition Features






MoRF SequenceStartStop




1) PEFLDLDME
1030
1038