Description | Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MEGLKSARSSSAQWKNLFHRCLSQRTDTSEFRDFAKLMLNRYSIPARRLLDLLLASRSVTNVPWDPLIPLYVDTLHRLESVRTEDILESLLAHSTVSQKQVSAQNGSAAKEPVSTLMTDYCIIHNATIAATSGYAPKTVADAVNTFSALAKWIFALLSWNSSHKPVGDPVGSLTKSPDALAVFESLGILFAALVSTEKSVSALSAPRSKGWRNKLGQALSEYIPLCAGVSIPLRDRLEVLRKDFNLYDHDSEKSLEDTMMENVNISALEFESNVLDGSIINSRAGPYIYVNALLFGRPLVDDNMMVNYLNNRYGGDRMTLIEDLITAAFDVLSNGMYRNEPNRTMFIFRSFLVNKLPPFFAEMCASAIDPIPMELCITRALSRIDPNAFPSFSEMFAMQGNSILSDVRQEFLFACALHKLIPEASIERLLGENPMQTLPVGGQLRREDLVAQINNSPERAEQLINELESMEGNAGAIAGAITEVMHSLCSRKETMTLKNICNSLSRRPLSLDVMLLFISPSTILQPLCALLDAWKWGEEQGESQPVYDEFGSILLLVLAFKHKYVLSHYDLGISNSDSFVLRLLQHGSSSQRLEDLDEKQKNNLGAWITALFIAEGISDESMSSCSPQEFYLLVATLFSQSLAARETGKLEFETLKGGFEYLLEPFLLPSLVMALTWLGHHIWESESDLTTSLKLLLCLVKPSSISGEAQEIHRTVLLITAKSLEDQLKSIRIRHPSRNDIKPILEALEPYRSFQRRSTARYGEVEGWAANPAGGGVVASIRNTFSSFVFWSTSPEISMTPPSYTHRQIVAGIRLVGAVRVLRGIIDELKLQAETGSGDLALDIAATLICAPLAESFAVERAAFHPIDPSKDTVPRCPILTLRDALNVERDNIPKLIDSDMLRAELIVRLNRRVDALTAVTQMSQEVSNIDVGNIMQDINLEGEDMEMSDQRHHQGDEQPGQPDQGPDDAENLNDMLDAAVAAAAGEDGNENGQEMELGGIGGIGMGMDSGLDTSIDDVLNGADMGVGNPEFLDLDMEGMF |
Length | 1041 |
Position | Tail |
Organism | Emergomyces pasteurianus Ep9510 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.088 |
Instability index | 43.83 |
Isoelectric point | 4.84 |
Molecular weight | 114821.53 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
RuleBase:RU364142 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10994 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 94.14| 23| 64| 90| 112| 1 --------------------------------------------------------------------------- 90- 112 (38.07/26.81) LLAHSTVSQKQVS.AQNG.SAAKEP 128- 151 (18.49/ 9.01) IAATSGYAPKTVAdAVNTfSALAK. 156- 177 (37.58/26.37) LLSWNS.SHKPVG.DPVG.SLTKSP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 108.81| 34| 64| 891| 929| 2 --------------------------------------------------------------------------- 891- 929 (48.03/49.47) DNIPKLIDSDMLRAElivRLNRRVDAltAVTQMSQEVSN 957- 990 (60.78/44.95) DEQPGQPDQGPDDAE...NLNDMLDA..AVAAAAGEDGN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.77| 31| 34| 380| 412| 8 --------------------------------------------------------------------------- 380- 412 (46.90/29.60) ALSRIDPNAfpSFSEMFA...MQGNSILSDVRQEFL 416- 449 (42.87/21.24) ALHKLIPEA..SIERLLGenpMQTLPVGGQLRREDL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 215.55| 68| 138| 489| 558| 9 --------------------------------------------------------------------------- 489- 558 (117.00/77.97) CSRKETMTLKN..ICNSLSRRPLS.LDVMLLFISPSTILQP..LCALLDAWKW.GEEQGESQPvyDEFGSI.LLLVL 625- 699 (98.55/59.43) CSPQEFYLLVAtlFSQSLAARETGkLEFETLKGGFEYLLEPflLPSLVMALTWlGHHIWESES..DLTTSLkLLLCL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.93| 21| 686| 314| 335| 10 --------------------------------------------------------------------------- 314- 335 (33.41/26.01) GGDRMTLIEDLITAAFDVLsNG 1002- 1022 (39.52/26.07) GGIGMGMDSGLDTSIDDVL.NG --------------------------------------------------------------------------- |
IDR Sequence | Start | Stop |
1) DINLEGEDMEMSDQRHHQGDEQPGQPDQGPDDAENLNDMLDAAVAAAAGEDGNENGQEMELGGIGGIGMG 2) SGLDTSIDDVLNGADMGVGNPEFLDLDMEGM | 938 1010 | 1007 1040 |
MoRF Sequence | Start | Stop |
1) PEFLDLDME | 1030 | 1038 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab