<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10993

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSAIGPEQENDQRLVDGTLAPHNNGNYSNGPSHAKDVNLLSNASFGDSLPPELVHISQGFFPLAQLINRAAQQCWNDLTDLIAELADPQTAPSNSTSQAASAPITTTNGKYRPSTSAAENAQRKLRILEFAQAKRADFIKILVLSQWSRRAADVSRLIDIQAFIRMRYDCYNGAILSIGEMKRDLIRAQTSNPHLAMALEVLSTGKVAAMQERSFIPPKPLTPKTMLKTLRKINKTIRTRLVLHDQLPSAFTNYIVHDGRVTFKVPTEFEVDLSIAHESHSSQFFFVDIRFLFSPSPPTPTGRLLDELDSRVNAMLMHSGLTGCYNLLHNLVLSNKITILYHQATELARGHWLDTLRVEILHRTLVVQYWINRPGPKSWIEIGIKSGRRKDRMSDGSTFESPMLGLRWMRDNKEGESKYIKFNSELLSMEAILRSVIAQHIAFLLQSTYERLSQGRLYASGALSASLQTSMSEPGDCFFDVQLTRGKDLRVIIEPVSGAIIFRPTPLLLNRHDIDRSFERPIIDDILFRISRLRSAAATEEVESLADALGWEAVNSRDIKGEDLRRIFPPNILRYALFFRKSWECHWGVAYTCSMDGDNWWVVELRAPSSDKGPFSPQSARMITGRFGGLRERLNYGSFGQLDHALSGMLAIHANARYLSELHGIHHFPPLRNLYLGPQLQVPSVSIRFQSGSLPLALQISPSIATKKEPAIRDTIRLSFRGIDPSSQFAILLAHGHLSRKVRDLGLLAGHLDPTITFQPNGCGFAMRFLTPVGQPMIIQLLARLQQLERVISTLETLKRKSLKPLSVTLSRIKFAYAADEDTIASIDFNYHEQAIASDIDSITLLSKQTPLMILRMSIDFHPQNPHRRIKESLTATLNGLRPGAGAGAGLEAVLQLLVITLPILKALDRISTDPHTDKPGNTGIQITARSSKIFHLRYPSIRYRFCIHAALRRDRVVWILKDMTIASDKTGRESLESKLKEHLYIVHGDGWQGLDNGAIADCETIGNLLYTLHGIVGEYISSEAGGDLGLDKLGTRNGKSGGDAGGTGGDGSSGPAGQRADQTNPAGRGPANNNPNPKLGETDIGMSTGMGVGGARSGGLGGARSLVAGNNGAAMATQTQSDSKAENQDMKSAQNNKNNAARNMANASGNGSDVDFIMID
Length1169
PositionTail
OrganismEmergomyces pasteurianus Ep9510
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emergomyces.
Aromaticity0.07
Grand average of hydropathy-0.251
Instability index40.21
Isoelectric point9.11
Molecular weight128645.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10993
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.96|      12|      21|    1034|    1045|       1
---------------------------------------------------------------------------
 1034- 1045 (21.73/12.49)	GGDLGLDKLGTR
 1057- 1068 (23.23/13.98)	GGDGSSGPAGQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.73|      33|      45|     297|     333|       2
---------------------------------------------------------------------------
  297-  333 (51.70/46.36)	IRFLFSPSPPTPTGRLLDELdsRVNamLMHSGLTGCY
  345-  377 (58.03/37.90)	ITILYHQATELARGHWLDTL..RVE..ILHRTLVVQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.39|      47|      49|     717|     765|       4
---------------------------------------------------------------------------
  714-  762 (75.14/58.86)	TKKEPAirDTIRLSFRGIDPSSQFAI..LLAH.GHLSRKVRDLGLLAGH.LDP
  763-  813 (68.25/46.61)	TITFQP..NGCGFAMRFLTPVGQPMIiqLLARlQQLERVISTLETLKRKsLKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.99|      42|     417|     171|     221|       6
---------------------------------------------------------------------------
  175-  217 (67.77/69.35)	RYDCYNGAILSIGEMKRDLIrAQTSNPHLAMALEVLSTGKVAA
  426-  467 (70.22/42.66)	KYIKFNSELLSMEAILRSVI.AQHIAFLLQSTYERLSQGRLYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.05|      26|      50|     555|     582|      12
---------------------------------------------------------------------------
  555-  582 (41.33/28.00)	DALGWEAVNSRDIKGEdlRRIFPPNILR
  604-  629 (48.71/27.33)	DGDNWWVVELRAPSSD..KGPFSPQSAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.12|      37|     825|      95|     131|      16
---------------------------------------------------------------------------
   95-  131 (65.07/40.04)	DPQT.APSNSTSQ..AASAPI...TTTNGKYRPSTSAAENAQR
  922-  964 (55.04/32.71)	DPHTdKPGNTGIQitARSSKIfhlRYPSIRYRFCIHAALRRDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10993 with Med14 domain of Kingdom Fungi
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