Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKYMDERFERVQRALTSLIDSITKYTPSTTQAHDLAAADKELSDGLTELQTHQNNLLRIQELRKETEDLDAQIKSTVSLLWSTRKEITGTPTTSYPSSGPRYDFTYTDLLNYARRISPYTLPPPGVTNGVDLSAPPADQQATASAEQTPVTATSDSVPAPNGAAVASTASQPTDPSQPDAAPQQTSFSTALPEHMTEAVNLLEGAVFYPWPGEERIRSGALDLCQRLADAGVDPKGYDPEEQERQRQAEAEERKRREAIEDAERKRREEERFAQMARERAAAAERERLMSHDAGGAGQASPGAAGRQEKKQFQFMGGLDDDEDED |
Length | 326 |
Position | Middle |
Organism | Coniochaeta ligniaria NRRL 30616 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Coniochaetales> Coniochaetaceae> Coniochaeta. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.896 |
Instability index | 54.06 |
Isoelectric point | 4.68 |
Molecular weight | 35945.89 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP10984 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.70| 18| 19| 241| 258| 1 --------------------------------------------------------------------------- 214- 238 (22.54/ 9.82) EERIRsgaldlcQRLADAGVDPKGY 241- 258 (31.16/16.08) EEQER.......QRQAEAEERKRRE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 58.60| 19| 19| 278| 296| 3 --------------------------------------------------------------------------- 278- 296 (30.86/16.62) RERAAAAER.ERLMSHDAGG 299- 318 (27.73/14.25) QASPGAAGRqEKKQFQFMGG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.02| 12| 15| 85| 96| 4 --------------------------------------------------------------------------- 85- 96 (21.46/13.33) RKEITGTPTTSY 102- 113 (22.56/14.33) RYDFTYTDLLNY --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 66.16| 15| 31| 152| 166| 5 --------------------------------------------------------------------------- 152- 166 (23.60/12.95) TATSDSVPAPNGAAV 170- 183 (18.45/ 8.46) ASQPTDPSQPDAAP. 186- 200 (24.12/13.41) TSFSTALPEHMTEAV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAAERERLMSHDAG 2) SPGAAGRQEKKQFQFMGGLDDDEDED 3) YDFTYTDLLNYARRI | 282 301 103 | 295 326 117 |
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