<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP10977

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGDLPDEIQHITAQSMPLGLLLSRLAQISHNHLQELIAELATRPVAQNSAVNGAPDYRTTTAEDTSPESLEKKRLLLEFIQNLHTRWVKALVITEWSRKAEPVGRLIDVKNYIEQQLAHFTQQAYAIADVKKQLIFARLPSPDLKTALEVLSSGDVSWMPEFGYIEPPPQTPDEQLHWMENLNTLLSVRLTLDEYEKIPYHFRNYSIGSGRVTFKVEGEFEVDLTIADEDSEKQFWFIDFRFLFNPAPDELSERLRLFLEDKVNEALATDGLTGCYKFLHGFTLTHQITEFTRQALELSRTRWVDSLKIERLNRAMSVQYWQSRPQIGLKSWIILGTHSGKKPQDDPSATSRLFLRWFRDNKEVKDLDISLDSSNISAERILKTVIARHVEYILSSIHSKLLTFPRFSKREASLRLTISKDEPAASQLVMRLSRDNELTVKIDPVTGTFALSPSTRVITQGERQLNTNGKDPVAEGHIILEKTRCFHTMEELTRRGKSMGWHTHSPGVKPDELKPFLTIRDSFQALWLRRSGWKSDWSVLVIMSLGGDKWWLVQTSETPEGVRRIKSFTSINITGQPRPTEEFFHNLNIFATGMISQIIDLKVLEERGIKHVERSQSNHALPAQIRLPAVYVRLSEIVPGLTQRSGSTKGWAVDYVKITFKGAQQSANGSPGTQPGDAGQSRVGAGSIKAVSDATITVADKAKFKDLKGNVDSDVTFNTRLGEFVLHLRQEIGTSLIDTLTSRLQAIGRLMDFIDAMRKSGGGIVCESVTMREIVFSYGDDLLGQSDPGTQQHPRWMARLNLTSGPNIKISLDKGNPHLRLLDLLEALANSENLRDLPNHLKLTFSMLKALEGIEDSWAKIAENNDGGVDIHHWSLDYTTITYLLPGIDPKQPRELALGLKHAYRAGQDYWYLEYQTKHGVTVYPHSEFTTILKPIFDSRGEDWKGLGTGAAGQVGKGIELLLSVVNNAVLSLVGSPPPPPLPQQQQQQQHNPSQSFGESAVSTTTKMSRQSSQQRPSQSATQPSSQSQQQGGGGVSRPGTKPTSAIVLD
Length1050
PositionTail
OrganismConiochaeta ligniaria NRRL 30616
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Coniochaetales> Coniochaetaceae> Coniochaeta.
Aromaticity0.08
Grand average of hydropathy-0.404
Instability index48.29
Isoelectric point6.89
Molecular weight117686.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP10977
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.58|      22|      23|     807|     828|       1
---------------------------------------------------------------------------
  800-  821 (35.58/24.77)	LNLTSGPNIKISLDKGNPHLRL
  822-  843 (34.99/24.22)	LDLLEALANSENLRDLPNHLKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.76|      18|      21|     631|     650|       2
---------------------------------------------------------------------------
  631-  650 (25.96/20.68)	YVRLSeiVPGLTQRSGSTKG
  655-  672 (29.80/17.21)	YVKIT..FKGAQQSANGSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.41|      39|     213|      71|     113|       3
---------------------------------------------------------------------------
   71-  113 (59.48/61.01)	EKKRLLLEFIQnlhTRWVKALVITEWSRkAEPV....GR.LIDVKNYI
  290-  333 (58.92/44.96)	EFTRQALELSR...TRWVDSLKIERLNR.AMSVqywqSRpQIGLKSWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.90|      11|      95|     249|     259|       4
---------------------------------------------------------------------------
  228-  238 (20.50/12.77)	DEDSEKQFWFI
  249-  259 (18.38/10.65)	DELSERLRLFL
  270-  279 (18.02/10.29)	DGLTGCYK.FL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.70|      11|      23|     986|     996|       5
---------------------------------------------------------------------------
  986-  996 (22.04/12.51)	QQQQQHNPSQS
 1010- 1020 (20.66/11.29)	RQSSQQRPSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.99|      14|     549|     176|     191|       8
---------------------------------------------------------------------------
  158-  171 (29.19/16.20)	WMPEFGYIEPPPQT
  178-  191 (23.79/ 8.88)	WMENLNTLLSVRLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.44|      24|      26|     720|     743|      10
---------------------------------------------------------------------------
  720-  743 (39.71/26.95)	RLGEFVLHLRQEIGTSLIDTLTSR
  749-  772 (42.73/29.58)	RLMDFIDAMRKSGGGIVCESVTMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.29|      14|      25|     443|     465|      12
---------------------------------------------------------------------------
  443-  456 (24.97/27.56)	DPVTGTFALSPSTR
  471-  484 (24.32/ 6.84)	DPVAEGHIILEKTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP10977 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVGSPPPPPLPQQQQQQQHNPSQSFGESAVSTTTKMSRQSSQQRPSQSATQPSSQSQQQGGGGVSRPGTKPTSAIVLD
973
1050










Molecular Recognition Features






MoRF SequenceStartStop




NANANA